HLA-DRB1 Polymorphisms and Rheumatologic Manifestations in Chronic Hepatitis C

Background/Aims Hepatitis C has been associated with rheumatologic manifestations (HCV-related RM). Clinically, HCV-related RM may be indistinguishable from the symptoms that occur in diffuse connective tissue diseases (DCTD-related RM), making the differential diagnosis difficult. Host genetic factors, such as the Human Leukocyte Antigens (HLA) polymorphisms were associated with HCV infection, however, there are no studies that discriminate between HCV-related RM and DCTD-related RM. This study focused on verifying associations between HLA-DRB1 and RM in patients with chronic hepatitis C, aiming to distinguish between DCTD-related RM and HCV-related RM. Methods The participants were 152 individuals, of both sexes, aged between 18 and 80 years, and affected by chronic hepatitis C. The patients underwent rheumatologic physical examination and HLA-class II (HLA-DRB1) typing was performed by PCR-SSO (Polymerase Chain Reaction-sequence Specific Oligonucleotides). Results A significant number of patients with rheumatologic complaints (73%) not attributed to other causes was observed. DRB1*08 allele seems to confer protection against RM in chronic hepatitis C. There is no susceptibility association between HLA-DRB1 alleles and RM. Conclusion The absence of association between HLA-DRB1 and the rheumatologic manifestations studied suggests that the pathophysiological pathways of DCTD-related RM and HCV-related RM are distinct.

Automated summary

This study aimed to investigate the association between HLA-DRB1 gene and rheumatologic manifestations in chronic hepatitis C patients. The results showed no association between HLA-DRB1 alleles and these rheumatologic symptoms, suggesting distinct pathophysiological pathways for DCTD-related RM and HCV-related RM.