Measurement Properties of Clinical Scales Rating the Severity of Blepharospasm: A Multicenter Observational Study

Background Several scales have been proposed to clinically evaluate the Motor Severity of Blepharospasm (BSP) but information about their measurement properties as a multicenter instrument is limited. Objective To compare the measurement properties of four clinical scales in rating the severity of BSP in a large sample of patients from multiple sites. Methods The Burke-Fahn-Marsden Scale (BFMS), the Global Dystonia Severity Rating Scale (GDRS), the Jankovic Rating Scale (JRS), and the Blepharospasm Severity Rating Scale (BSRS) were administered to 211 patients across 10 sites who were also requested to self-complete the Blepharospasm Disability Index (BDI). Measurement properties to be assessed included inter-/intra-observer agreement, item-to-total correlation, internal consistency, floor and ceiling effect, convergent/discriminant validity, and adherence to the distribution of BDI. Results The BFMS had unsatisfactory measurement properties, the GDRS had acceptable reliability but other properties could not be completely testable; the JRS had satisfactory measurement properties but the scale did not accurately reflect the distribution of disability parameter (BDI) in the sample, and the BSRS had satisfactory measurement properties and also showed the best adherence to the distribution of BDI in the assessed sample. Conclusion The comparison of the measurement properties of four rating scales to assess the motor state of the BSP in a large sample of patients from multiple sites showed that the GDRS should be used to simultaneously assess BSP and dystonia in other body parts, while the JRS (easier to use) and BSRS (better to discriminate severity) should be used to assess BSP alone.

Automated summary

This study compared the measurement properties of four clinical scales in assessing the severity of Blepharospasm (BSP) in a large sample of patients from multiple sites. The Global Dystonia Severity Rating Scale (GDRS) was found to be suitable for assessing both BSP and dystonia in other body parts, while the Jankovic Rating Scale (JRS) and Blepharospasm Severity Rating Scale (BSRS) were suitable for assessing BSP alone.