Antimicrobial Use in Pediatric Oncology and Hematology: Protocol for a Multicenter Point-Prevalence Study With Qualitative Expert Panel Assessment

Article Infectious Diseases

A host signature based on TRAIL, IP-10, and CRP for reducing antibiotic overuse in children by differentiating bacterial from viral infections: a prospective, multicentre cohort study

Cihan Papan et al.

Summary: The study validates the high diagnostic performance of the TRAIL/IP-10/CRP signature in a broad paediatric cohort and supports its potential to reduce antibiotic overuse in children with viral infections.

CLINICAL MICROBIOLOGY AND INFECTION (2022)

添加到收藏夹

Article Pediatrics

Prospective Audit of Gentamicin Drug Monitoring Practice in a Pediatric Cancer Center

Sarah Herberger et al.

Summary: This study investigated the dosing regimen of single daily infusion Gentamicin in pediatric cancer patients. The results showed high adherence to the dosing regimen, with a high proportion of cycles reaching the target C (max) levels, and no patients experiencing nephrotoxicity.

KLINISCHE PADIATRIE (2021)

添加到收藏夹

Article Oncology

8th European Conference on Infections in Leukaemia: 2020 guidelines for the use of antibiotics in paediatric patients with cancer or post-haematopoietic cell transplantation

Thomas Lehrnbecher et al.

Summary: The ECIL-8 Paediatric Group reviewed literature and formulated recommendations for antibiotic use in paediatric cancer patients and those undergoing haematopoietic cell transplantation, focusing on factors such as clinical stability and previous infection or colonization by resistant bacteria.

LANCET ONCOLOGY (2021)

添加到收藏夹

Review Pediatrics

Febrile neutropenia in pediatric and adolescent cancer patients

K. Bochennek et al.

Summary: Febrile neutropenia is a common potential emergency in children and adolescents with cancer, as their immune systems are compromised by treatment-induced immunosuppression. Early antibiotic treatment is crucial in preventing life-threatening infections, especially bacterial and fungal infections in certain risk groups. This article provides an overview of managing pediatric cancer patients with febrile neutropenia, emphasizing the importance of timely intervention.

MONATSSCHRIFT KINDERHEILKUNDE (2021)

添加到收藏夹

Review Infectious Diseases

Optimising Antimicrobial Selection and Duration in the Treatment of Febrile Neutropenia in Children

Jessica E. Morgan et al.

Summary: Febrile neutropenia (FN) is a common complication of cancer treatment in children, requiring risk stratification, optimal antimicrobial selection, and timely treatment. The focus is on improving patient experience and reducing infection risk.

INFECTION AND DRUG RESISTANCE (2021)

添加到收藏夹

Review Immunology