3.8 Article

Antimicrobial Use in Pediatric Oncology and Hematology: Protocol for a Multicenter Point-Prevalence Study With Qualitative Expert Panel Assessment

期刊

JMIR RESEARCH PROTOCOLS
卷 11, 期 6, 页码 -

出版社

JMIR PUBLICATIONS, INC
DOI: 10.2196/35774

关键词

point-prevalence study; antimicrobial stewardship; pediatric oncology; pediatric hematology; expert panel; antimicrobial resistance; oncology; cancer; pediatrics

资金

  1. European Society of Clinical Microbiology and Infectious Diseases (ESCMID)
  2. Deutsche Gesellschaft fur Krankenhaushygiene (DGKH)
  3. Deutsche Gesellschaft fur Padiatrische Infektiologie (DGPI)
  4. Stiftung Kreissparkasse Saarbrucken

向作者/读者索取更多资源

This study aims to evaluate the appropriate use of antimicrobials in pediatric cancer patients through a point-prevalence study and expert panel review. The results will inform interventions for internal guidelines and antimicrobial stewardship programs, and contribute to the integration of antimicrobial stewardship principles in pediatric oncology and hematology.
Background: Because infections are a major driver of morbidity and mortality in children with hematologic or oncologic diseases, antimicrobials are frequently prescribed in pediatric oncology practice. However, excess or inappropriate use of antimicrobials is directly linked to the emergence of antimicrobial resistance. Although point-prevalence studies have examined the extent of antimicrobial use, a comprehensive qualitative evaluation of individual antimicrobial prescriptions remains lacking. Objective: The aim of this study is to identify appropriate versus inappropriate antimicrobial use among pediatric cancer patients in a point-prevalence study, followed by an expert panel adjudication process and a subsequent report of these findings to participating centers. This study also aims to improve the quality of patient care by informing centers about discrepancies between internal standards of care and national guidelines. Methods: Our point-prevalence study is performed at pediatric cancer centers in Germany and Austria. All patients under 18 years old who are hospitalized at the time of the study are included. As a supplement to the point-prevalence study, an expert panel is qualitatively assessing each of the antimicrobial prescriptions at the participating centers to review local guidelines and compare them with national guidelines. Results: As of December 2021, the point-prevalence survey has been conducted at 30 sites and expert panel adjudication for qualitative assessment of each antimicrobial use is ongoing. Results of the study are expected in 2022. Conclusions: This is the first point-prevalence study conducted among pediatric cancer centers with an integrated, multistep, qualitative approach that assesses each antimicrobial prescription. The results of this study will inform possible interventions for internal guidelines and antimicrobial stewardship programs implemented at pediatric cancer centers. In addition, local guidelines will be compared with national guidelines. Furthermore, this study will contribute to the overall integration of antimicrobial stewardship principles and initiatives in pediatric oncology and hematology, thereby improving safety and quality of care for children and adolescents with cancer and blood disorders.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

3.8
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据