4.5 Article

Omeprazole treatment manifests anxiolytic effects in a cysteamine hydrochloride induced mouse model of gastrointestinal disorder

期刊

HELIYON
卷 8, 期 6, 页码 -

出版社

ELSEVIER SCI LTD
DOI: 10.1016/j.heliyon.2022.e09787

关键词

Omeprazole; Anxiety; Open field test; Elevated plus maze; Proton pump inhibitor; Cysteamine hydrochloride

资金

  1. Rashtriya Uchchatar Shiksha Abhiyan (RUSA) 2.0, Biological Sciences, Bharathidasan University [TN RUSA: 311/RUSA (2.0) /2018 dt. 02/12/2020]
  2. University Grants Commission-Faculty Recharge Programme (UGC-FRP) , New Delhi, India
  3. RUSA 2.0 project fellowship [BDU/RUSA 2.0/TRP/BS/Date 22/04/2021]

向作者/读者索取更多资源

Omeprazole treatment alleviates anxiety-like behaviors in a cysteamine HCl induced mouse model of gastrointestinal disorder, supporting its anxiolytic properties. However, adverse effects associated with inappropriate intake of omeprazole may exist, necessitating further research on its long-term effects on brain function.
Omeprazole, a proton pump inhibitor (PPI), has widely been used to treat various gastrointestinal (GI) disorders. Notably, many clinical symptoms of GI disorders have been known to be associated with anxiety. In recent years, an exponentially increased number of subjects with abnormal ageing, neurological deficits, and psychiatric problems simultaneously exhibit GI dysfunctions as well as anxiety. Considering the fact, drugs that are used to treat GI disorders can be speculated to mitigate anxiety-related symptoms, and vice versa. Although, omeprazole treatment has been reported to result in development of anxiety and neurocognitive decline, ample reports suggest that omeprazole treatment is beneficial for the positive regulation of neuroplasticity. While underlying mechanisms of omeprazole-mediated neurological alterations remain obscure, the available scientific data on the omeprazole induced adverse effects in the brain appear to be inadequate, uncertain, and controversial. Hence, this study revisited the effect of omeprazole treatment on the degree of anxiety-like behaviours in a cysteamine hy-drochloride (HCl) induced mouse model of GI disorder using open field test (OFT), light-dark box (LDB) test and elevated plus maze (EPM). Results revealed that omeprazole treatment mitigates anxiety-related behaviours in the cysteamine HCl induced animal model of GI disorder. Thus, this study assuredly supports and validates the anxiolytic properties of omeprazole. However, the adverse effects associated with inappropriate intake of omeprazole may not completely be excluded. Therefore, this study advocates the future direction in determining the long-term effects of omeprazole on the brain functions.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据