Commentary on The Role of Alginate Hydrogels as a Potential Treatment Modality for Spinal Cord Injury: A Comprehensive Review of the Literature

Article Pharmacology & Pharmacy

Sodium alginate and naloxone loaded macrophage-derived nanovesicles for the treatment of spinal cord injury

Xiaoyao Liu et al.

Summary: The prepared nanovesicles (NAL-SA-MVs) can reduce the concentration of free Ca2+ at the site of spinal cord injury, inhibit inflammation, and protect neurons. In vivo and in vitro studies showed that NAL-SA-MVs could decrease inflammation, reduce neuronal apoptosis, and significantly improve motor function in mice. Therefore, NAL-SA-MVs have tremendous potential for the treatment of spinal cord injury.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2022)

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Review Clinical Neurology

The Role of Alginate Hydrogels as a Potential Treatment Modality for Spinal Cord Injury: A Comprehensive Review of the Literature

Ryan Jarrah et al.

Summary: Alginate hydrogels have been shown to be efficient and promising substrates for various applications in the treatment of spinal cord injury, including tissue engineering, drug delivery, neural regeneration, and cell-based therapies. They have the potential to improve clinical outcomes as a pro-regenerative and anti-degenerative agent.

NEUROSPINE (2022)

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Review Clinical Neurology

Novel Methods of Necroptosis Inhibition for Spinal Cord Injury Using Translational Research to Limit Secondary Injury and Enhance Endogenous Repair and Regeneration

Brian Fiani et al.

Summary: Spinal cord injuries present a significant challenge in terms of treatment outcomes, with the necroptotic pathway playing a key role in limiting recovery. Therapeutic interventions that target this pathway early on following injury may help prevent irreversible damage caused by rapid accumulation of reactive oxygen species and inflammation. Future research on potential therapeutics is crucial in minimizing long-term consequences of severe spinal cord injury.

NEUROSPINE (2021)

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Article Pharmacology & Pharmacy