期刊
JOURNAL OF EXPERIMENTAL BOTANY
卷 67, 期 16, 页码 4801-4812出版社
OXFORD UNIV PRESS
DOI: 10.1093/jxb/erw210
关键词
Cyclic peptides; cyclotides; drug design; insecticide; kalata B1; plant defence
资金
- Australian Research Council [DP150100443]
- National Health and Medical Research Council, Australia [APP1084965]
- GSK Award for Research Excellence
We review cyclotides-cyclic proteins from plants-for their unique structures, functions, and pharmaceutical applications, with the aim of stimulating interest for additional research in the field.Cyclotides are plant-derived cyclic peptides that have a head-to-tail cyclic backbone and three conserved disulphide bonds that form a cyclic cystine knot motif. They occur in plants from the Violaceae, Rubiaceae, Cucurbitaceae, Fabaceae, and Solanaceae families, typically with 10-100 cyclotides in a given plant species, in a wide range of tissues, including flowers, leaves, stems, and roots. Some cyclotides are expressed in large amounts (up to 1g kg(-1) wet plant weight) and their natural function appears to be to protect plants from pests or pathogens. This article provides a brief overview of their discovery, distribution in plants, and applications. In particular, their exceptional stability has led to their use as peptide-based scaffolds in drug design applications. They also have potential as natural 'ecofriendly' insecticides, and as protein engineering frameworks.
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