期刊
ACS APPLIED POLYMER MATERIALS
卷 4, 期 8, 页码 6080-6091出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsapm.2c00892
关键词
composite nanofibers; electrospun membranes; tensile strength; antimicrobial activity; cell viability
资金
- Project Partnerships for knowledge transfer in the field of polymer materials used in biomedical engineering [89/03.09.2020, IDP_40_443, 86/8.09.2016]
- European Regional Development Fund by the Competitiveness Operational Programme 2014- 2020, Axis 1Research, Technological Development and Innovation
- CNCSIS-UEFISCSU [89/03.09.2020, SMIS 105689]
- [PN-III-P1-1.1-TE2019-0639]
In this study, electrospinning was used to fabricate low Young's modulus composite membranes based on copoly(ether imide)s and silver-loaded zeolite L nanoparticles. These membranes exhibited antimicrobial activity and showed biocompatibility.
One of the most versatile techniques to fabricate micro-/nanoscaled nonwoven fibrous materials is represented by electrospinning. Due to its easy availability and versatility, increasing efforts worldwide have focused on the preparation of natural and/or synthetic composite membranes that eventually mimic the artificial extracellular matrix. Electrospun composite membranes based on copoly(ether imide)s derived from Jeffamine, and additionally doped with silver-loaded zeolite L nanoparticles (ze-Ag+), have been successfully produced in the present work via a solution electrospinning process. The morphology of the developed electrospun membranes based on pure copoly(ether imide)s (co-PEI-0) and doped copoly(ether imide)s (co-PEI-0/zeolite or co-PEI-0/silver-containing zeolite L nanoparticles) was investigated by scanning electron microscopy (SEM), while the homogeneous distribution of the nanoparticles within the electrospun fibers has been introspected by means of energy dispersive X-ray spectroscopy (EDX). Young's modulus was reduced from 0.677 MPa for pure co-PEI electrospun fibers to 0.221 MPa when silver-loaded zeolite L nanoparticles were attached to the electrospun composite membranes. Antimicrobial activity of the products demonstrated that the samples containing silver-exchanged zeolite L nanoparticles present an inhibitory effect against both Gram-negative (Escherichia coli ATCC 25922) and Gram-positive (Staphylococcus aureus ATCC 25923) bacteria. Furthermore, a biocompatibility check by studying the cell viability and cell morphology of the developed composite membranes revealed no cytotoxic activity.
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