Design of an Experimental Study for the Simultaneous Determination of Cefepime, Piperacillin and Tazobactam Using Micellar Organic Solvent-Free HPLC

Article Chemistry, Analytical

Eco-Friendly and Sensitive HPLC and TLC Methods Validated for the Determination of Betahistine in the Presence of Its Process-Related Impurity

Adel Ehab Ibrahim et al.

Summary: Reducing the consumption of organic solvents is a crucial step towards greener analytical methodologies. The combination of SDS and Brij-35 surfactants as organic modifiers provides a safe and cost-effective alternative.

SEPARATIONS (2022)

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Article Chemistry, Analytical

Validated Capillary Zone Electrophoresis Method for Impurity Profiling and Determination of NiII(3-OMe-Salophene)

Sami El Deeb et al.

Summary: A capillary zone electrophoresis method was developed for the determination of Ni-II(3-OMe-salophene). The method was optimized to achieve efficient separation and migration time. The proposed method showed good analytical performance in separating Ni-II(3-OMe-salophene) and structurally related impurities.

SEPARATIONS (2022)

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Article Pharmacology & Pharmacy

Estimation of cefepime, piperacillin, and tazobactam clearance with iohexol-based glomerular filtration rate in paediatric patients

Hiie Soeorg et al.

Summary: In children and young adults with haemato-oncological disease and infection, iohexol-based estimated glomerular filtration rate (GFR) can better predict the clearance of cefepime, piperacillin, and tazobactam.

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2022)

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Article Multidisciplinary Sciences

Cost-effective, green HPLC determination of losartan, valsartan and their nitrosodiethylamine impurity: application to pharmaceutical dosage forms

Soad S. Abd El-Hay et al.

Summary: ACE inhibitors drugs containing carcinogenic impurities like NDEA have prompted the development of green and sensitive HPLC method for their detection and quantification.

ROYAL SOCIETY OPEN SCIENCE (2022)

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Article Chemistry, Analytical

Development of a solvent-free micellar HPLC method for determination of five antidiabetic drugs using response surface methodology

Eman A. Bahgat et al.

Summary: A totally green mixed micellar LC method was developed and used to analyze various antidiabetic combinations. The method was optimized and successfully applied to determine the examined drugs in laboratory mixtures and pharmaceutical products. Compared to previous methods, the new method was shown to be more efficient and effective.

MICROCHEMICAL JOURNAL (2022)

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Article Infectious Diseases

Determinants of Antimicrobial Resistance among the Different European Countries: More than Human and Animal Antimicrobial Consumption

Ana C. Silva et al.

Summary: The study explored the factors driving AMR across European countries, finding that human ambulatory consumption of antibiotics and health expenditure are significantly associated with AMR rate. It was noted that low healthcare expenditure and private healthcare expenditure have a positive impact on the AMR rate.

ANTIBIOTICS-BASEL (2021)

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Article Biochemical Research Methods