期刊
FOOD SCIENCE AND HUMAN WELLNESS
卷 11, 期 4, 页码 795-805出版社
KEAI PUBLISHING LTD
DOI: 10.1016/j.fshw.2022.03.010
关键词
Ganoderma lucidum polysaccharides; Polyporus umbellatus polysaccharides; Immune function; Intestinal flora; Colitis
资金
- National Key R&D Program of China [2018YFD0400204]
- National Natural Science Foundation of China [81974503, 81871095]
- Key International S&T Cooperation Program of China [2016YFE113700]
The compound GPP, composed of water-soluable Ganoderma lucidum polysaccharides (GLP) and Polyporus umbellatus polysaccharides (PUP), enhances immune function in mice by enhancing macrophage cell function and natural killer (NK) cell activity. GPP also increases the diversity of intestinal microorganisms and has a positive effect on colitis model mice.
Previous study have demonstrated that a compound composed of water-soluable Ganoderma lucidum polysaccharides (GLP) and Polyporus umbellatus polysaccharides (PUP) in a ratio of 3 : 1 named GPP enhances innate immune function in mice through enhancing the function of macrophage cells and activity of natural killer (NK) cells. Here in our research, we further investigated the effect of GPP on the diversity and composition of intestinal flora, and explored its effect on colitis model mice. The immunoregulatory verification experiments of GPP were conducted in both normal and DSS-induced mice model. Our research showed that GPP increased the diversity of intestinal microorganisms in mice with the extension of administration time. Daily GPP intake attenuated DSS-induced colon injury, protected the splenic lymphocyte proliferation ability, enhanced the serum hemolysin synthesis, and increased peripheral phagocytes and NK cell activity in model mice. Comparisons of the predominant gene pathways of the bacterial microbiota showed that DNA repair and recombination, base mismatch repair pathways was stronger in GPP-treatment group than in control group, indicating the possible molecular mechanisms of immune function regulation. Our study showed that GPP regulated immune function in both health and colitis model, and had a positive effect on maintaining intestinal flora homeostasis. ?? 2022 Beijing Academy of Food Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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