期刊
BIOSENSORS-BASEL
卷 12, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/bios12080565
关键词
single-molecule sensor; STM break junction; ionic detection; pH detection; nucleotide detection
资金
- National Natural Science Foundation of China [22102150, 22172146, 21872126, 21573198]
- Zhejiang Provincial Natural Science Foundation of China [LQ21B030010]
- Leading Talent Program of Science and Technology Innovation in Zhejiang [2020R52022]
This review outlines the primary advances and potential of the STM break junction technique for qualitative identification and quantitative detection at a single-molecule level. The summary of three operation principles demonstrates that single-molecule electrical measurements with break junction techniques have high sensitivity and excellent selectivity.
Single-molecule recognition and detection with the highest resolution measurement has been one of the ultimate goals in science and engineering. Break junction techniques, originally developed to measure single-molecule conductance, recently have also been proven to have the capacity for the label-free exploration of single-molecule physics and chemistry, which paves a new way for single-molecule detection with high temporal resolution. In this review, we outline the primary advances and potential of the STM break junction technique for qualitative identification and quantitative detection at a single-molecule level. The principles of operation of these single-molecule electrical sensing mainly in three regimes, ion, environmental pH and genetic material detection, are summarized. It clearly proves that the single-molecule electrical measurements with break junction techniques show a promising perspective for designing a simple, label-free and nondestructive electrical sensor with ultrahigh sensitivity and excellent selectivity.
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