期刊
TOXICS
卷 10, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/toxics10080477
关键词
dichlorvos; Spondias mombin; brain science; neurotoxicity; inflammation; quercetin-3-O-beta-D-glucopyranoside; cognitive defects; antioxidant status; locomotion impairment; neurodegenerative diseases
资金
- Taif University, Taif, Saudi Arabia [TURSP-2020/202]
The study demonstrates that the Quercetin-3-O-beta-D-glucopyranosiderich fraction (Q3G-RF) from Spondias mombin leaves has a neuroprotective effect on oxidative and neuronal damages caused by dichlorvos (DDVP) in the brain of rats, potentially due to its potent antioxidant, prophylactic, and chemotherapeutic properties.
The study investigated the prophylactic efficacy of Quercetin-3-O-beta-D-glucopyranosiderich fraction (Q3G-RF) from Spondias mombin leaves on oxidative and neuronal damages in the brain sections of dichlorvos (DDVP)-treated female Wistar rats. Female Wistar rats assigned into 5 groups of 12 rats each were orally treated with appropriate regimens. Group 1 received sunflower oil. Group 2 received DDVP (8.8 mg/kg). Group 3 received Q3G-RF (100 mg/kg). Group 4 received DDVP + Q3G-RF (50 mg/kg). Group 5 received DDVP + Q3G-RF (100 mg/kg). Q3G-RF reversed DDVP-induced cognitive deficits in the rats and reversed rearing activity impairment; it protected against the following DDVP-induced activities: inhibition of cholinesterases (acetylcholinestere (AChE), butyrylcholinesterase (BuChE)), elevated marker-enzymes (acylpeptide hydrolase (APEH), dipeptidylpeptidase IV (DPP-IV), prolyl oligopeptidase (POP)), oxidative stress (total thiol, malondialdehyde, hydrogen peroxide (H2O2), reduced glutathione and the activities glutathione S-transferase, catalase, superoxide dismutase, and glutathione peroxidase), inflammation (myeloperoxidase (MPO), tumor necrosis factor-alpha (TNF-alpha), nitric oxide, interleukin-1 beta (IL-1 beta)), and apoptosis (caspase-3) in the hippocampus, striatum, and prefrontal cortex of the experimental rats exposed to DDVP (p < 0.05). Conclusively, the neuroprotective effects of Q3G-RF on DDVP-induced toxicity in the hippocampus, striatum, and prefrontal cortex in brain of rats suggests its potent antioxidant, prophylactic, and chemotherapeutic properties.
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