Detection of glutathione in dairy products based on surface-enhanced infrared absorption spectroscopy of silver nanoparticles

Review Biochemistry & Molecular Biology

New insights into the regulatory roles of glutathione in NLRP3-inflammasome-mediated immune and inflammatory responses

Tianli Zhang et al.

Summary: Glutathione plays a crucial role in cellular metabolism and redox homeostasis. Recent studies have shown its central role in regulating the activation of NLRP3 inflammasome, which is associated with various diseases.

JOURNAL OF BIOCHEMISTRY (2022)

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Article Chemistry, Applied

Signal optimized rough silver nanoparticle for rapid SERS sensing of pesticide residues in tea

Md Mehedi Hassan et al.

Summary: Surface-enhanced Raman scattering (SERS) is highly sensitive for monitoring food safety. Flower-like silver nanoparticles were synthesized for pesticide sensing in green tea with successful detection limits and satisfactory accuracy and precision.

FOOD CHEMISTRY (2021)

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Article Biochemistry & Molecular Biology

Effect of glutathione liposomes on diabetic nephropathy based on oxidative stress and polyol pathway mechanism

Huajuan Shen et al.

Summary: The novel antioxidant glutathione liposomes (GSH-LIP) show promise as a new therapeutic option for diabetic nephropathy by improving bioavailability, antioxidant capacity, and targeting renal pathology.

JOURNAL OF LIPOSOME RESEARCH (2021)

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Article Ophthalmology

Glutathione Improves the Antioxidant Activity of Vitamin C in Human Lens and Retinal Epithelial Cells: Implications for Vitreous Substitutes

Nguyen K. Tram et al.

Summary: Glutathione was found to protect lens and retinal cells from the toxic effect of vitamin C and extend the stability of vitamin C in vitro, indicating it may be an effective addition to intraocular implants to prevent oxidative stress post-vitrectomy.

CURRENT EYE RESEARCH (2021)

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Review Behavioral Sciences

The glutathione system in Parkinson's disease and its progression

Geir Bjorklund et al.

Summary: Redox dysfunctions and neuro-oxidative stress play a major role in the pathophysiology and progression of Parkinson's disease (PD). Lowered GSH metabolism and a low GSH/GSSG ratio following oxidative stress are associated with mitochondrial dysfunctions and neuroinflammatory processes accompanying PD. Antioxidant approaches may have therapeutic efficacy in treating PD and its progression by neutralizing reactive oxygen species.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2021)

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Article Nanoscience & Nanotechnology

Reaction between Graphene Oxide and Intracellular Glutathione Affects Cell Viability and Proliferation

Baojin Ma et al.

Summary: The reaction between graphene oxide and glutathione affects the intracellular redox balance, increasing reactive oxygen species levels and inhibiting cell viability and proliferation.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Biophysics

Gold nanorod arrays enable highly sensitive bacterial detection via surface-enhanced infrared absorption (SEIRA) spectroscopy

Araz Norouz Dizaji et al.

Summary: Infrared spectroscopy is a powerful method for the identification of chemical and biological molecules, but the low absorbance of biological molecules has been a challenge. This study introduced the use of 3D anisotropic gold nanorod arrays as a highly active SEIRA platform for bacterial detection, which showed successful results.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

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Article Chemistry, Applied

Single run analysis of glutathione and its disulfide in food samples by liquid chromatography coupled to on-line post-column derivatization

Apostolia Tsiasioti et al.

Summary: The study successfully developed a method for determining glutathione and its disulfide using liquid chromatography with on-line postcolumn derivatization and fluorimetric detection. The method showed high sensitivity and throughput, with accurate determination of analytes content in various food samples. It is considered a reliable and promising analytical tool for estimating the redox status of glutathione in different food matrices.

FOOD CHEMISTRY (2021)

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Article Biochemistry & Molecular Biology

Protein S-glutathionylation decreases superoxide/hydrogen peroxide production xanthine oxidoreductase

Megan Letourneau et al.

Summary: The study demonstrates that protein S-glutathionylation can inhibit ROS production by cytoplasmic and mitochondrial enzymes, with glutathionylation reactions being enzymatically mediated by GST. Additionally, it was found that bacterial XO is also a target for glutathionylation.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

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Article Chemistry, Inorganic & Nuclear

Thiolation and Carboxylation of Glutathione Synergistically Enhance Its Lead-Detoxification Capabilities

Luca Sauser et al.

Summary: A novel amino acid was found to enhance the detoxification capability of a synthetic peptide towards lead, while noncanonical amino acids showed potential advantages in enhancing lead binding.

INORGANIC CHEMISTRY (2021)

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Article Environmental Sciences

Catalytic reduction of 4-nitrophenol by green silver nanocomposites assembled using microbial extracellular polymer substances

Shanshan Pi et al.

Summary: The research investigated the mechanism of catalytic reduction of 4-nitrophenol by silver nanocomposites assembled using microbial EPSs, showing that UV light promoted the reduction of Ag+ to Ag0, forming efficient Ag nanoparticles catalyst.

ENVIRONMENTAL RESEARCH (2021)

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Review Nutrition & Dietetics

Dairy bioactive proteins and peptides: a narrative review

Nancy Auestad et al.

Summary: Milk proteins are known for their high nutritional quality due to their essential amino acid composition and various bioactivities, and can be easily separated into casein and whey fractions. Encrypted peptides in these proteins are increasingly recognized as beneficial biologically active metabolites for human health.

NUTRITION REVIEWS (2021)

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Article Chemistry, Analytical

Dual-mode of magnetic assisted Au@Ag SERS tags and cationic conjugated UCNPs for qualitative and quantitative analysis of multiple foodborne pathogens

Yi Xu et al.

Summary: A new dual-mode optical-nano-sensor was developed to effectively isolate, discriminate, and inactivate multiple foodborne pathogens by utilizing magnetic SERS tags and functionalized upconversion nanoparticles. This sensor can rapidly and simply detect and kill bacteria in contaminated food, contributing to food safety monitoring.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Article Engineering, Environmental

Fate and removal of silver nanoparticles during sludge conditioning and their impact on soil health after simulated land application

Zainab Abdulsada et al.

Summary: The research investigated the fate and removal of AgNPs during the chemical conditioning of anaerobically digested sludge and their impact on soil bacteria and health after land application. Results showed minimal impact of conditioned AgNPs at 20 mg AgNPs/g soil on the presence and diversity of important phyla in soil. The study provides new insight into the potential impacts of AgNPs and different sludge conditioning chemicals on soil biological activities and plant growth.

WATER RESEARCH (2021)

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Article Chemistry, Multidisciplinary

Silver Nanoparticle-Decorated Silica Nanospheres and Arrays as Potential Substrates for Surface-Enhanced Raman Scattering

Junfang Li et al.

Summary: Poly(vinylpyrrolidone) was employed as a modifier and reductant to deposit silver nanoparticles on silica nanospheres, creating SiO2@Ag, which can assemble into SiO2@Ag arrays. These substrates exhibit strong Raman enhancement capabilities and high detection sensitivity for trace organic pollutants like rhodamine 6G.

ACS OMEGA (2021)

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Article Biochemistry & Molecular Biology

Elucidating the contribution of mitochondrial glutathione to ferroptosis in cardiomyocytes

Sehwan Jang et al.

Summary: Ferroptosis is a programmed iron-dependent cell death associated with lipid peroxidation, particularly phospholipids. Mitochondria play a crucial role in ferroptosis by being sensitive to ferroptotic stimuli and contributing to lipid peroxidation. The transport of reduced glutathione to mitochondria through DIC and OGC carrier proteins plays a key role in ferroptosis, and inhibiting these carriers can aggravate the process. Additionally, dihydrolipoic acid acts as an essential cofactor for mitochondrial enzymes and can attenuate ferroptosis by directly reducing peroxidized phospholipids.

REDOX BIOLOGY (2021)

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Review Biochemistry & Molecular Biology

Glutathione Participation in the Prevention of Cardiovascular Diseases

Deyamira Matuz-Mares et al.

Summary: Cardiovascular diseases result in high mortality rates globally, with oxidative stress playing a key role in worsening patient conditions. Reactive oxygen and nitrogen species are generated during the development of these diseases, contributing to the deleterious effects on patients.

ANTIOXIDANTS (2021)

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Review Biochemistry & Molecular Biology

Glutathione-coordinated metal complexes as substrates for cellular transporters

Stephen A. Pearson et al.

Summary: Glutathione plays important roles in both prokaryotes and eukaryotes, including detoxification of metals and transportation of iron-sulfur clusters. Different ABC transporters have similar functions in different organisms, indicating common evolutionary features in these processes.

METALLOMICS (2021)

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Article Otorhinolaryngology