期刊
FRONTIERS IN NUTRITION
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnut.2022.953426
关键词
moyamoya; choline; betaine; risk factors; subtypes
资金
- National Key Research and Development Program of China
- Beijing Municipal Organization Department Talents Project
- National Natural Science Foundation of China
- Beijing Municipal Administration of Hospitals' Mission Plan
- [2021YFC2500502]
- [2015000021469G219]
- [81701137]
- [SML20150501]
Circulating choline and betaine are negatively associated with the risk of MMD and its subtypes.
BackgroundCirculating choline pathway nutrients play a critical role in first stroke and recurrent stroke. However, there is limited information available on the effects of choline pathway nutrients on the risk of moyamoya disease (MMD) and its subtypes. We investigated the association between circulating choline and betaine and the incident risk of MMD and its subtypes. MethodsThe case-control study enrolled 385 patients with MMD [i.e., 110 transient ischemic attack (TIA)-type MMD, 157 infarction-type MMD, and 118 hemorrhagic-type MMD] and 89 matched healthy controls. ResultsSerum choline and betaine were inversely related to the risk of MMD and its subtypes. The risk of MMD was decreased with each increment in choline level [per 1 mu mol increase: odds ratio (OR), 0.756; 95% CI, 0.678-0.843] and betaine level (per 1 mu mol increase: OR, 0.952; 95% CI, 0.932-0.972), respectively. When choline and betaine were assessed as quartiles, compared with the lowest quartile of serum choline and betaine levels, those in the highest quartile had a significantly decreased risk of MMD (choline, Q4 vs. Q1: OR, 0.023; 95% CI, 0.005-0.118; betaine, Q4 vs. Q1: OR, 0.058; 95% CI, 0.018-0.184). ConclusionsSerum choline and betaine were associated with the decreased risk of MMD and its subtypes.
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