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Improving Cancer Care for Patients With CKD : The Need for Changes in Clinical Trials

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A Unifying Approach for GFR Estimation: Recommendations of the NKF-ASN Task Force on Reassessing the Inclusion of Race in Diagnosing Kidney Disease

Cynthia Delgado et al.

Summary: The National Kidney Foundation and the American Society of Nephrology have made recommendations regarding the consideration of race in GFR estimation. They suggest implementing the CKD-EPI creatinine equation without the race variable in all US laboratories and promoting the use of cystatin C for more accurate estimation. They also encourage research on new filtration markers and interventions to eliminate racial disparities. The unified approach should be adopted nationwide.

AMERICAN JOURNAL OF KIDNEY DISEASES (2022)

Article Urology & Nephrology

Research Priorities for Kidney-Related Research-An Agenda to Advance Kidney Care: A Position Statement From the National Kidney Foundation

Mary Baliker et al.

Summary: Despite the high prevalence and economic burden of chronic kidney disease (CKD) in the United States, federal funding for kidney-related research, prevention, and education activities is inadequate compared to other chronic diseases. More federal support is needed to promote critical research that will expand knowledge of kidney health and disease, develop new and effective therapies, and reduce health disparities. The National Kidney Foundation (NKF) held Research Roundtables to identify priorities for preclinical and clinical kidney-related research. These priorities, presented in a position statement, offer attainable opportunities for groundbreaking innovations that will benefit patients with kidney disease in the next 5-10 years.

AMERICAN JOURNAL OF KIDNEY DISEASES (2022)

Article Transplantation

Sudden cardiac death in dialysis patients: different causes and management strategies

Simonetta Genovesi et al.

Summary: SCD and SCA in ESKD patients are different clinical situations with potentially different management strategies, with modifiable risk factors such as potassium and calcium concentration in dialysate. In this population, fatal arrhythmias may be due more frequently to bradyarrhythmias than to tachyarrhythmias.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2021)

Article Urology & Nephrology

Prediction of Kidney Drug Clearance: A Comparison of Tubular Secretory Clearance and Glomerular Filtration Rate

Yan Chen et al.

Summary: Secretory solute clearance measurements can predict kidney drug clearances, and there is tight linkage between GFR and proximal tubular secretory clearance in stable outpatients, indicating that eGFR is a useful surrogate for predicting secretory drug clearances in such patients.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

Article Urology & Nephrology

A multi-center study on safety and efficacy of immune checkpoint inhibitors in cancer patients with kidney transplant

Naoka Murakami et al.

Summary: Immune checkpoint inhibitors pose a high risk of acute rejection in kidney transplant patients but may lead to improved cancer outcomes. Prospective studies are needed to determine optimal immunosuppression strategies to improve patient outcomes.

KIDNEY INTERNATIONAL (2021)

Article Radiology, Nuclear Medicine & Medical Imaging

Use of Intravenous Gadolinium-based Contrast Media in Patients with Kidney Disease: Consensus Statements from the American College of Radiology and the National Kidney Foundation

Jeffrey C. Weinreb et al.

Summary: This article summarizes the inaugural consensus statements developed and endorsed by the American College of Radiology and the National Kidney Foundation to standardize care for patients with kidney disease receiving intravenous gadolinium-based contrast media. The article highlights the low risk of nephrogenic systemic fibrosis from group II GBCM in advanced kidney disease patients, and emphasizes the need to balance potential harms and benefits when considering MRI with GBCM in patients with acute kidney injury or low eGFR.

RADIOLOGY (2021)

Article Oncology

Continuing to Broaden Eligibility Criteria to Make Clinical Trials More Representative and Inclusive: ASCO-Friends of Cancer Research Joint Research Statement

Edward S. Kim et al.

Summary: The purpose of broadening clinical trial eligibility criteria is to increase the inclusivity and representativeness of trial populations, with the goal of making evidence more informative for a broader patient population. Implementation of these recommendations is intended to ease patient eligibility determination and accelerate clinical trial accrual.

CLINICAL CANCER RESEARCH (2021)

Article Urology & Nephrology

Kidney-Related Research in the United States: A Position Statement From the National Kidney Foundation and the American Society of Nephrology

Ryan Murray et al.

Summary: Kidney disease is a significant public health issue in the United States, affecting over 37 million Americans. Increasing research investment is crucial for identifying interventions to slow disease progression, reduce incidence of kidney failure, and improve quality of life. Racial, ethnic, and socioeconomic disparities characterize kidney disease, and addressing these disparities through research investment can positively impact public health in the US.

AMERICAN JOURNAL OF KIDNEY DISEASES (2021)

Editorial Material Urology & Nephrology

US Renal Data System 2020 Annual Data Report: Epidemiology of Kidney Disease in the United States

Kirsten L. Johansen et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2021)

Article Urology & Nephrology

Understanding and Overcoming the Challenges Related to Cardiovascular Trials Involving Patients with Kidney Disease

Julie H. Ishida et al.

Summary: Addressing the challenges and solutions for involving patients with kidney disease in cardiovascular clinical trials can be improved by focusing on building the business case, re-examining study design and implementation, and changing the clinical trial culture in nephrology. Regulatory and financial incentives can help mitigate financial concerns related to patient involvement, while thoughtful study design and risk mitigation strategies can address concerns about affecting efficacy or safety results by including kidney disease patients. Closer collaboration between nephrologists and cardiologists is essential for prioritizing the participation of patients with kidney disease in clinical trials and ultimately building the evidence base for optimal management of cardiovascular disease in this population.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

Article Urology & Nephrology

A pre-specified analysis of the DAPA-CKD trial demonstrates the effects of dapagliflozin on major adverse kidney events in patients with IgA nephropathy

David C. Wheeler et al.

Summary: Dapagliflozin reduced the risk of kidney failure and slowed the progression of chronic kidney disease in patients, particularly those with IgA nephropathy, with a favorable safety profile.

KIDNEY INTERNATIONAL (2021)

Article Multidisciplinary Sciences

Evaluating eligibility criteria of oncology trials using real-world data and AI

Ruishan Liu et al.

Summary: The study found that using a data-driven approach to broaden trial eligibility criteria can increase the number of eligible patients and decrease the hazard ratio of overall survival. Many patients who were initially not eligible under the trial criteria could potentially benefit from the treatments.

NATURE (2021)

Article Medicine, General & Internal

Comparison of Clinical Characteristics Between Clinical Trial Participants and Nonparticipants Using Electronic Health Record Data

James R. Rogers et al.

Summary: This study found that clinical trial participants generally had fewer comorbidities and less medication use than nonparticipants across a variety of disease domains, by combining electronic health record and trial enrollment data. This suggests that a more comprehensive approach to evaluating trials may be beneficial for addressing concerns about the generalizability of clinical trial results.

JAMA NETWORK OPEN (2021)

Article Oncology

A phase I, open-label study evaluating the safety and pharmacokinetics of trifluridine/tipiracil in patients with advanced solid tumors and varying degrees of renal impairment

Muhammad Wasif Saif et al.

Summary: This phase I study showed that FTD/TPI is safe and tolerable at the recommended dose of 35 mg/m(2) in patients with mild/moderate RI, while patients with severe RI may require a reduced dose of 20 mg/m(2). TPI AUC was significantly higher in patients with RI compared to those with normal renal function, with severity of RI correlating with increased TPI AUC.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2021)

Article Urology & Nephrology

A Unifying Approach for GFR Estimation: Recommendations of the NKF-ASN Task Force on Reassessing the Inclusion of Race in Diagnosing Kidney Disease

Cynthia Delgado et al.

Summary: A Task Force developed recommendations for reassessing inclusion of race in GFR estimation in the United States. The recommendations include immediate implementation of a creatinine equation refit without the race variable and increasing the use of cystatin C, as well as encouraging research on new filtration markers and interventions to eliminate racial and ethnic disparities.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

Article Medicine, General & Internal

Evaluating the impact and rationale of race-specific estimations of kidney function: estimations from US NHANES, 2015-2018

Jennifer W. Tsai et al.

Summary: The study indicates that racial adjustment of eGFR in Black patients may result in more individuals meeting diagnostic criteria for kidney disease, qualifying for nephrologist referral, and becoming eligible for transplant evaluation and waitlist inclusion. Recommendations are provided for addressing this issue at institutional and individual levels.

ECLINICALMEDICINE (2021)

Article Computer Science, Information Systems

Towards clinical data-driven eligibility criteria optimization for interventional COVID-19 clinical trials

Jae Hyun Kim et al.

Summary: This research evaluated the impact of eligibility criteria on recruitment and clinical outcomes of COVID-19 trials using EHR data. Adjusting the thresholds of common eligibility criteria based on COVID-19 patient characteristics resulted in observing more composite events from fewer patients. This supports data-driven optimization of participant selection for improved statistical power of COVID-19 trials.

JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION (2021)

Article Urology & Nephrology

Comparison of Equations To Estimate Glomerular Filtration Rate and Their Impact on Frequency of Cisplatin-associated Acute Kidney Injury

Shveta S. Motwani et al.

Summary: In estimating GFR in cancer patients receiving cisplatin-based chemotherapy, the CKD-EPI equation showed superior diagnostic performance with the highest positive predictive value and area under the curve. The CKD-EPI and MDRD equations, along with their BSA-modified counterparts, demonstrated the closest agreement with the lowest coefficient of variation. Using CKD-EPI to define eGFR >= 60 ml/min per 1.73 m(2) led to the lowest incidence of cisplatin-associated AKI.

KIDNEY360 (2021)

Review Pharmacology & Pharmacy

Exploring the burden of short-term CHOP chemotherapy adverse events in post-transplant lymphoproliferative disease: a comprehensive literature review in lymphoma patients

Crystal Watson et al.

Summary: The study reveals that short-term adverse events caused by CHOP treatment in lymphoma patients are associated with significant humanistic and economic burden, including impacts on patients' quality of life and increased healthcare costs.

JOURNAL OF DRUG ASSESSMENT (2021)

Review Urology & Nephrology

Kidney disease trials for the 21st century: innovations in design and conduct

William G. Herrington et al.

NATURE REVIEWS NEPHROLOGY (2020)

Editorial Material Oncology

Improving Cancer Care for Patients With Chronic Kidney Disease

Ben Sprangers et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

Article Medicine, General & Internal

Dapagliflozin in Patients with Chronic Kidney Disease

Hiddo J. L. Heerspink et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes

George L. Bakris et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Urology & Nephrology

Estimation of Kidney Function in Oncology Implications for Anticancer Drug Selection and Dosing

Morgan A. Casal et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2019)

Article Medicine, General & Internal

Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy

V. Perkovic et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Review Radiology, Nuclear Medicine & Medical Imaging

A Systematic Review of 639 Patients with Biopsy-confirmed Nephrogenic Systemic Fibrosis

Hanieh Attari et al.

RADIOLOGY (2019)

Article Urology & Nephrology

Quantity and Reporting Quality of Kidney Research

Markos Kyriakos Tomidis Chatzimanouil et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2019)

Article Multidisciplinary Sciences

Agreement and Precision Analyses of Various Estimated Glomerular Filtration Rate Formulae in Cancer Patients

Wiwat Chancharoenthana et al.

SCIENTIFIC REPORTS (2019)

Editorial Material Critical Care Medicine

Contrast-associated acute kidney injury is a myth: Yes

Stephan Ehrmann et al.

INTENSIVE CARE MEDICINE (2018)

Editorial Material Critical Care Medicine

Contrast-associated acute kidney injury is a myth: No

Steven D. Weisbord et al.

INTENSIVE CARE MEDICINE (2018)

Editorial Material Critical Care Medicine

Contrast-associated acute kidney injury is a myth: We are not sure

Kianoush Kashani et al.

INTENSIVE CARE MEDICINE (2018)

Letter Medicine, General & Internal

Representation of Patients With Chronic Kidney Disease in Trials of Cancer Therapy

Abhijat Kitchlu et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2018)

Review Radiology, Nuclear Medicine & Medical Imaging

Propensity Score Matching as a Substitute for Randomized Controlled Trials on Acute Kidney Injury After Contrast Media Administration: A Systematic Review

Ilona A. Dekkers et al.

AMERICAN JOURNAL OF ROENTGENOLOGY (2018)

Review Medicine, Research & Experimental

Factors associated with clinical trials that fail and opportunities for improving the likelihood of success: A review

David B. Fogel

CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS (2018)

Article Urology & Nephrology

Guidelines for treatment of renal injury during cancer chemotherapy 2016

Shigeo Horie et al.

CLINICAL AND EXPERIMENTAL NEPHROLOGY (2018)

Article Oncology

New Model for Estimating Glomerular Filtration Rate in Patients With Cancer

Tobias Janowitz et al.

JOURNAL OF CLINICAL ONCOLOGY (2017)

Editorial Material Oncology

Enrollment of older adults on oncology trials: An FDA perspective

Harpreet Singh et al.

JOURNAL OF GERIATRIC ONCOLOGY (2017)

Review Radiology, Nuclear Medicine & Medical Imaging

Contrast Media Controversies in 2015: Imaging Patients With Renal Impairment or Risk of Contrast Reaction

Matthew S. Davenport et al.

AMERICAN JOURNAL OF ROENTGENOLOGY (2015)

Article Radiology, Nuclear Medicine & Medical Imaging

The Challenges in Assessing Contrast-Induced Nephropathy: Where Are We Now?

Matthew S. Davenport et al.

AMERICAN JOURNAL OF ROENTGENOLOGY (2014)

Article Urology & Nephrology

Lifetime Incidence of CKD Stages 3-5 in the United States

Morgan E. Grams et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2013)

Article Multidisciplinary Sciences

Nephrogenic Systemic Fibrosis in Denmark - A Nationwide Investigation

Tina R. Elmholdt et al.

PLOS ONE (2013)

Article Radiology, Nuclear Medicine & Medical Imaging

Intravenous Contrast Material-induced Nephropathy: Causal or Coincident Phenomenon?

Robert J. McDonald et al.

RADIOLOGY (2013)

Article Radiology, Nuclear Medicine & Medical Imaging

Contrast Material-induced Nephrotoxicity and Intravenous Low-Osmolality Iodinated Contrast Material

Matthew S. Davenport et al.

RADIOLOGY (2013)

Review Radiology, Nuclear Medicine & Medical Imaging

Frequency of Acute Kidney Injury Following Intravenous Contrast Medium Administration: A Systematic Review and Meta-Analysis

Jennifer S. McDonald et al.

RADIOLOGY (2013)

Article Medicine, General & Internal

Estimating Glomerular Filtration Rate from Serum Creatinine and Cystatin C

Lesley A. Inker et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Article Medicine, General & Internal

Incidence of acute kidney injury in cancer patients: A Danish population-based cohort study

Christian Fynbo Christiansen et al.

EUROPEAN JOURNAL OF INTERNAL MEDICINE (2011)

Article Urology & Nephrology

Cystatin C Identifies Chronic Kidney Disease Patients at Higher Risk for Complications

Carmen A. Peralta et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2011)

Article Oncology

Cancer and renal insufficiency results of the BIRMA study

N. Janus et al.

BRITISH JOURNAL OF CANCER (2010)

Editorial Material Radiology, Nuclear Medicine & Medical Imaging

Intravenous Contrast Medium-induced Nephrotoxicity: Is the Medical Risk Really as Great as We Have Come to Believe?

Richard W. Katzberg et al.

RADIOLOGY (2010)

Article Medicine, General & Internal

A New Equation to Estimate Glomerular Filtration Rate

Andrew S. Levey et al.

ANNALS OF INTERNAL MEDICINE (2009)

Review Oncology

Renal insufficiency and anticancer drugs in elderly cancer patients: A subgroup analysis of the IRMA study

Vincent Launay-Vacher et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2009)

Article Transplantation

Nephron number and individual glomerular volumes in male Caucasian and African American subjects

Monika A. Zimanyi et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2009)

Review Physiology

The origin of the 1.73-m2 body surface area normalization:: problems and implications

James G. Heaf

CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING (2007)

Article Urology & Nephrology

Renal function testing

MH Rosner et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2006)

Review Oncology

Accurate measurement of individual glomerular filtration rate in cancer patients: an ongoing challenge

K Holweger et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2005)

Article Urology & Nephrology

The number, quality, and coverage of randomized controlled trials in nephrology

GFM Strippoli et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2004)

Article Radiology, Nuclear Medicine & Medical Imaging

Contrast media as markers of GFR

B Frennby et al.

EUROPEAN RADIOLOGY (2002)