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Renal Sympathetic Denervation for Hypertension

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Article Medicine, General & Internal

Long-term efficacy and safety of renal denervation in the presence of antihypertensive drugs (SPYRAL HTN-ON MED): a randomised, sham-controlled trial

Felix Mahfoud et al.

Summary: In this study, the long-term safety and efficacy of renal denervation were evaluated. The results showed that renal denervation produced a clinically meaningful and lasting blood pressure reduction up to 36 months, independent of concomitant antihypertensive medications and without major safety events.

LANCET (2022)

Article Medicine, General & Internal

Ultrasound renal denervation for hypertension resistant to a triple medication pill (RADIANCE-HTN TRIO): a randomised, multicentre, single-blind, sham-controlled trial

Michel Azizi et al.

Summary: Renal denervation through ultrasound treatment shows promising results in reducing blood pressure for patients with resistant hypertension, with greater effectiveness compared to a sham procedure within 2 months and similar safety outcomes. This may provide an alternative approach for patients with resistant hypertension to avoid adding more antihypertensive medications.

LANCET (2021)

Article Cardiac & Cardiovascular Systems

Catheter-based alcohol-mediated renal denervation for the treatment of uncontrolled hypertension: design of two sham-controlled, randomized, blinded trials in the absence (TARGET BP OFF-MED) and presence (TARGET BP I) of antihypertensive medications

Felix Mahfoud et al.

Summary: The TARGET BP trials are large-scale, international, randomized trials aimed at investigating the safety and efficacy of alcohol-mediated RDN for treating uncontrolled hypertension. The trials have completed enrollment for one cohort and will continue to enroll more subjects in another cohort to evaluate the novel RDN method.

AMERICAN HEART JOURNAL (2021)

Article Cardiac & Cardiovascular Systems

Changes in blood pressure after crossover to ultrasound renal denervation in patients initially treated with sham in the RADIANCE-HTN SOLO trial

Felix Mahfoud et al.

Summary: In the RADIANCE-HTN SOLO study, patients originally assigned to a sham procedure who crossed over to receive ultrasound RDN treatment showed significant reductions in blood pressure during long-term follow-up, with no major procedure-related adverse events.

EUROINTERVENTION (2021)

Article Cardiac & Cardiovascular Systems

Alcohol-Mediated Renal Denervation Using the Peregrine System Infusion Catheter for Treatment of Hypertension

Felix Mahfoud et al.

JACC-CARDIOVASCULAR INTERVENTIONS (2020)

Article Cardiac & Cardiovascular Systems

12-Month Results From the Unblinded Phase of the RADIANCE-HTN SOLO Trial of Ultrasound Renal Denervation

Michel Azizi et al.

JACC-CARDIOVASCULAR INTERVENTIONS (2020)

Article Cardiac & Cardiovascular Systems

Atrial fibrillation reduction by renal sympathetic denervation: 12 months' results of the AFFORD study

Lida Feyz et al.

CLINICAL RESEARCH IN CARDIOLOGY (2019)

Article Peripheral Vascular Disease

Cost-Effectiveness of Rena Denervation Therapy for Treatment-Resistant Hypertension: A Best Case Scenario

Enayet Karim Chowdhury et al.

AMERICAN JOURNAL OF HYPERTENSION (2018)

Article Cardiac & Cardiovascular Systems

Potential US Population Impact of the 2017 ACC/AHA High Blood Pressure Guideline

Paul Muntner et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2018)

Article Cardiac & Cardiovascular Systems

Trends in Healthcare Expenditures Among US Adults With Hypertension: National Estimates, 2003-2014

Elizabeth B. Kirkland et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2018)

Review Cardiac & Cardiovascular Systems

2018 ESC/ESH Guidelines for the management of arterial hypertension

Bryan Williams et al.

EUROPEAN HEART JOURNAL (2018)

Meeting Abstract Cardiac & Cardiovascular Systems

ConfidenHT™ system - diagnostic electrical mapping of renal nerves for optimizing renal denervation procedures

Konstantinos Tsioufis et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2018)

Article Transplantation

Hypertension in kidney transplantation is associated with an early renal nerve sprouting

Alessandro Mauriello et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2017)

Article Cardiac & Cardiovascular Systems

Transcatheter Alcohol-Mediated Perivascular Renal Denervation With the Peregrine System First-in-Human Experience

Tim A. Fischell et al.

JACC-CARDIOVASCULAR INTERVENTIONS (2016)

Review Physiology

Role of renal sensory nerves in physiological and pathophysiological conditions

Ulla C. Kopp

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2015)

Article Cardiac & Cardiovascular Systems

Impact of Lesion Placement on Efficacy and Safety of Catheter-Based Radiofrequency Renal Denervation

Felix Mahfoud et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2015)

Article Cardiac & Cardiovascular Systems

Predictors of blood pressure response in the SYMPLICITY HTN-3 trial

David E. Kandzari et al.

EUROPEAN HEART JOURNAL (2015)

Article Cardiac & Cardiovascular Systems

12-Month Blood Pressure Results of Catheter-Based Renal Artery Denervation for Resistant Hypertension The SYMPLICITY HTN-3 Trial

George L. Bakris et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2015)

Article Cardiac & Cardiovascular Systems

Anatomic Assessment of Sympathetic Peri-Arterial Renal Nerves in Man

Kenichi Sakakura et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2014)

Article Medicine, General & Internal

A Controlled Trial of Renal Denervation for Resistant Hypertension

Deepak L. Bhatt et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Review Cardiac & Cardiovascular Systems

Renal sympathetic nervous system and the effects of denervation on renal arteries

Arun Kannan et al.

WORLD JOURNAL OF CARDIOLOGY (2014)

Article Physiology

Renal sensory and sympathetic nerves reinnervate the kidney in a similar time-dependent fashion after renal denervation in rats

Jan Mulder et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2013)

Review Cardiac & Cardiovascular Systems

Catheter-Based Renal Denervation for Resistant Hypertension: Rationale and Design of the SYMPLICITY HTN-3 Trial

David E. Kandzari et al.

CLINICAL CARDIOLOGY (2012)

Article Cardiac & Cardiovascular Systems

Cost-Effectiveness and Clinical Effectiveness of Catheter-Based Renal Denervation for Resistant Hypertension

Benjamin P. Geisler et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2012)

Article Cardiac & Cardiovascular Systems

Catheter-based renal sympathetic denervation: chronic preclinical evidence for renal artery safety

Marian K. Rippy et al.

CLINICAL RESEARCH IN CARDIOLOGY (2011)

Letter Medicine, General & Internal

Renal Sympathetic-Nerve Ablation for Uncontrolled Hypertension.

Markus P. Schlaich et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

Article Medicine, General & Internal

Global burden of hypertension: analysis of worldwide data

PM Kearney et al.

LANCET (2005)