Role of m6A writers, erasers and readers in cancer

Article Endocrinology & Metabolism

METTL3-Induced miR-222-3p Upregulation Inhibits STK4 and Promotes the Malignant Behaviors of Thyroid Carcinoma Cells

Shaojian Lin et al.

Summary: This study suggests that the overexpression of METTL3 is associated with malignant behaviors in thyroid carcinoma (TC), and it promotes tumor development and metastasis by regulating the expression levels of miR-222-3p and STK4.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2022)

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Article Oncology

miR-302a-3p suppresses melanoma cell progression via targeting METTL3

Xiao Chang et al.

Summary: The miRNA-302 family, particularly miR-302a-3p, exerts tumor-suppressive roles in melanoma by targeting METTL3 and regulating various aspects of melanoma cell behaviors, such as proliferation, apoptosis, invasion, and migration.

JOURNAL OF CHEMOTHERAPY (2022)

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Article Medicine, General & Internal

The m6A methyltransferase METTL3 aggravates the progression of nasopharyngeal carcinoma through inducing EMT by m6A-modified Snail mRNA

Xiaofeng Yu et al.

Summary: The study revealed that METTL3 is upregulated in NPC tissues, and its levels are associated with clinical stage and metastatic status in NPC patients. High expression of METTL3 in NPC patients is linked to worse prognosis. Knockdown of METTL3 resulted in downregulation of Snail and N-cadherin, and upregulation of E-cadherin in NPC cells.

MINERVA MEDICA (2022)

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Article Biochemistry & Molecular Biology

Interaction of lncRNA MIR100HG with hnRNPA2B1 facilitates m6A-dependent stabilization of TCF7L2 mRNA and colorectal cancer progression

Hao Liu et al.

Summary: The study reveals that MIR100HG serves as a positive regulator of EMT in CRC, sustaining cetuximab resistance and promoting invasion and metastasis. It interacts with hnRNPA2B1 to control Wnt signaling transcriptional activity via regulation of TCF7L2 mRNA stability, forming a feedback loop that may contribute to cetuximab resistance and metastasis in CRC.

MOLECULAR CANCER (2022)

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Article Oncology

METTL3 modulates m6A modification of CDC25B and promotes head and neck squamous cell carcinoma malignant progression

Yu-qing Guo et al.

Summary: This study reveals that the levels of m6A modification and METTL3 expression are significantly increased in head and neck squamous cell carcinoma (HNSCC). METTL3 overexpression promotes HNSCC cell proliferation, migration, invasion, and angiogenesis, and is associated with poor prognosis in HNSCC patients.

EXPERIMENTAL HEMATOLOGY & ONCOLOGY (2022)

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Article Oncology

YTHDF1 Promotes Gastric Carcinogenesis by Controlling Translation of FZD7

Jingnan Pi et al.

Summary: This study reveals the oncogenic role of YTHDF1 in gastric cancer, showing its regulation of the Wnt/β-catenin signaling pathway through m(6)A modification. Inhibition of YTHDF1 can reduce gastric cancer cell proliferation and tumorigenesis, suggesting a new approach for targeting epigenetic regulators in cancer treatment.

CANCER RESEARCH (2021)

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Article Hematology

Role of c-Myc haploinsufficiency in the maintenance of HSCs in mice

Yue Sheng et al.

Summary: This study investigated the dosage effect of c-Myc on hematopoiesis and its role in the Wnt/beta-catenin pathway in HSC and bone marrow niche cells. The results demonstrated the critical role of Nr4a1, Nr4a2, and Jmjd3 as downstream targets of c-Myc in HSCs. Additionally, the study provided evidence of c-Myc-mediated Apc loss inducing IL6 secretion in endothelial cells and its impact on erythroid cell differentiation.

BLOOD (2021)

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Article Biotechnology & Applied Microbiology

METTL3-mediated maturation of miR-126-5p promotes ovarian cancer progression via PTEN-mediated PI3K/Akt/mTOR pathway

Xuehan Bi et al.

Summary: METTL3 promotes the maturation of miR-126-5p through m6A modification, which in turn targets PTEN to activate the PI3K/Akt/mTOR pathway in ovarian cancer progression. This study provides potential targets for future ovarian cancer treatment and reveals tumorigenic mechanisms regulated by m6A modification.

CANCER GENE THERAPY (2021)

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Article Cell Biology

METTL3 promotes the initiation and metastasis of ovarian cancer by inhibiting CCNG2 expression via promoting the maturation of pri-microRNA-1246

Xuehan Bi et al.

Summary: This study identified that METTL3 is overexpressed and hypomethylated in ovarian cancer tissues and cells. Decreased METTL3 can inhibit the proliferation and migration of ovarian cancer cells, while promoting apoptosis, providing new targets for treatment.

CELL DEATH DISCOVERY (2021)

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Article Cell Biology

IGF2BP2-modified circular RNA circARHGAP12 promotes cervical cancer progression by interacting m6A/FOXM1 manner

Fei Ji et al.

Summary: This study identified a novel m(6)A-modified circRNA upregulated in cervical cancer, which promoted tumor progression by interacting with the reader protein IGF2BP2 to stabilize FOXM1 mRNA. These findings provide new insights into cervical cancer biology and pathology.

CELL DEATH DISCOVERY (2021)

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Article Oncology

YTHDF1 promotes hepatocellular carcinoma progression via activating PI3K/AKT/mTOR signaling pathway and inducing epithelial-mesenchymal transition

Xiangyuan Luo et al.

Summary: YTHDF1 is overexpressed in HCC and associated with HCC grade. It promotes the growth of HCC cells by activating the PI3K/AKT/mTOR signaling pathway and inducing epithelial-mesenchymal transition (EMT) to enhance migration and invasion.

EXPERIMENTAL HEMATOLOGY & ONCOLOGY (2021)

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Article Cell Biology

m6A transferase METTL3-induced lncRNA ABHD11-AS1 promotes the Warburg effect of non-small-cell lung cancer

Lei Xue et al.

Summary: In NSCLC, lncRNA ABHD11-AS1 is upregulated and promotes proliferation and the Warburg effect. METTL3 enhances ABHD11-AS1 transcript stability to increase its expression.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

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Article Biochemistry & Molecular Biology

FTO demethylates m6A modifications in HOXB13 mRNA and promotes endometrial cancer metastasis by activating the WNT signalling pathway

Lin Zhang et al.

Summary: High expression of FTO in metastatic endometrial cancer promotes tumor metastasis and invasion both in vivo and in vitro by catalyzing demethylation modification in the 3'UTR region of HOXB13 mRNA, leading to activation of the WNT signaling pathway and downstream protein expression. Inhibitor ICG-001 targeting the WNT signaling pathway can block HOXB13 gene-induced tumor metastasis, suggesting a promising molecular intervention. This study sheds light on the relationship between obesity and endometrial cancer pathogenesis, highlighting future research directions.

RNA BIOLOGY (2021)

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Article Medicine, Research & Experimental

ALKBH5 Inhibited Cell Proliferation and Sensitized Bladder Cancer Cells to Cisplatin by m6A-CK2α-Mediated Glycolysis

Hao Yu et al.

Summary: In bladder cancer, downregulation of ALKBH5 is associated with worse prognosis, and knockdown of ALKBH5 promotes cell proliferation, migration, and invasion while decreasing sensitivity to cisplatin chemotherapy. ALKBH5 inhibits bladder cancer progression and sensitizes cells to cisplatin through regulation of the m6A-dependent casein kinase 2 (CK2)α-mediated glycolysis pathway.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

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Article Medicine, Research & Experimental

Oncogenic Role of Long Noncoding RNAMALAT1 in Thyroid Cancer Progression through Regulation of the miR-204/IGF2BP2/m6A-MYC Signaling

Mao Ye et al.

Summary: This study revealed that MALAT1 promotes TC progression by upregulating IGF2BP2 through competitive binding to miR-204.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

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Article Biochemistry & Molecular Biology

Exosomal lncRNA FOXD3-AS1 upregulates ELAVL1 expression and activates PI3K/Akt pathway to enhance lung cancer cell proliferation, invasion, and 5-fluorouracil resistance

Guangxian Mao et al.

Summary: In this study, we found that FOXD3-AS1 is upregulated in lung cancer tissues and cell lines, and enriched in lung cancer cell-derived exosomes. FOXD3-AS1 activates the PI3K/Akt pathway to promote lung cancer progression, providing a potential new strategy for lung cancer treatment.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2021)

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Article Biochemistry & Molecular Biology

miR-338-5p inhibits cell growth and migration via inhibition of the METTL3/m6A/c-Myc pathway in lung cancer

Hongyu Wu et al.

Summary: The study revealed that miR-338-5p inhibited lung cancer cell growth and migration by targeting METTL3 and c-Myc pathways. This may open up new possibilities for the diagnosis, prognosis, and treatment of lung cancer.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2021)

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Article Cell Biology

ALKBH5-mediated m6A demethylation of FOXM1 mRNA promotes progression of uveal melanoma

Lili Hao et al.

Summary: The study revealed that high expression of ALKBH5 is associated with poor outcome in uveal melanoma. ALKBH5 promotes UM progression by demethylating FOXM1 mRNA, potentially inducing EMT for cell metastasis.

AGING-US (2021)

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Article Biochemistry & Molecular Biology

m6A-YTHDF1-mediated TRIM29 upregulation facilitates the stem cell-like phenotype of cisplatin-resistant ovarian cancer cells

Liang Hao et al.

Summary: TRIM29 expression is upregulated in cisplatin-resistant ovarian cancer cells and clinical tissues, and is associated with poor prognosis. TRIM29 enhances the CSC-like characteristics of ovarian cancer cells, while knockdown of YTHDF1 suppresses these traits. The study suggests TRIM29 and YTHDF1 may serve as potential therapeutic targets for combating ovarian cancer recurrence.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)

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Article Medicine, Research & Experimental

N-6-methyladenosine (m(6)A) methyltransferase WTAP accelerates the Warburg effect of gastric cancer through regulating HK2 stability

Han Yu et al.

Summary: In gastric cancer, the expression of m(6)A and WTAP is up-regulated, with high WTAP expression correlating with poor prognosis. Functional experiments demonstrate that WTAP promotes proliferation and glycolytic capacity, while knockdown of WTAP suppresses tumor growth. Mechanistically, WTAP enhances HK2 mRNA stability by binding to the 3'-UTR m(6)A site.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Biochemistry & Molecular Biology

Omeprazole improves chemosensitivity of gastric cancer cells by m(6)A demethylase FTO-mediated activation of mTORC1 and DDIT3 up-regulation

Shuitu Feng et al.

Summary: The study found that omeprazole can enhance the inhibitory effect of chemotherapy drugs on gastric cancer cells by regulating m(6)A modification and the FTO eraser, which is important for improving chemosensitivity.

BIOSCIENCE REPORTS (2021)

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Article Biochemistry & Molecular Biology

The M6A methyltransferase METTL3 regulates proliferation in esophageal squamous cell carcinoma

Jiang Zou et al.

Summary: Esophageal squamous cell carcinoma (ESCC) is a deadly cancer with low survival rates, and the m(6)A methylation enzyme METTL3 plays a crucial role in promoting ESCC development.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Article Biochemistry & Molecular Biology

LncRNA HCG11 mediated by METTL14 inhibits the growth of lung adenocarcinoma via IGF2BP2/LATS1

Jun Mao et al.

Summary: The study showed that HCG11 was downregulated in LUAD and its inhibition of lung adenocarcinoma growth was mediated by METTL14 through the IGF2BP2/LATS1 pathway.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Article Oncology

METTL3 induces PLX4032 resistance in melanoma by promoting m6A-dependent EGFR translation

Poshan Yugal Bhattarai et al.

Summary: METTL3 enhances acquired resistance to PLX4032 by promoting EGFR upregulation through m6A modification, while knockout of METTl3 restores sensitivity to PLX4032 in melanoma cells.

CANCER LETTERS (2021)

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Article Oncology

Isorhapontigenin (ISO) inhibits EMT through FOXO3A/METTL14/ VIMENTIN pathway in bladder cancer cells

Ning Zhang et al.

Summary: This study demonstrates that ISO inhibits invasion of bladder cancer cells by affecting the expression of EMT markers Vimentin and METTL14, offering a novel insight into the upregulation of METTL14 by ISO.

CANCER LETTERS (2021)

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Article Biochemistry & Molecular Biology

METTL3 promotes adriamycin resistance in MCF-7 breast cancer cells by accelerating pri-microRNA-221-3p maturation in a m6A-dependent manner

Xiaoping Pan et al.

Summary: This study identified the METTL3/miR-221-3p/HIPK2/Che-1 axis as a potential mechanism for breast cancer cell resistance to adriamycin. Knockdown of METTL3 resulted in reduced expression of miR-221-3p, leading to decreased drug resistance and increased apoptosis in ADR-resistant MCF-7 cells.These findings suggest that targeting the METTL3/miR-221-3p/HIPK2/Che-1 axis may improve chemotherapy efficacy in breast cancer.

EXPERIMENTAL AND MOLECULAR MEDICINE (2021)

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Article Biochemistry & Molecular Biology

R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis

Ying Qing et al.

Summary: R-2-hydroxyglutarate (R-2HG) inhibits aerobic glycolysis in leukemia cells by targeting RNA modification, highlighting the therapeutic potential of targeting cancer epitranscriptomics and metabolism. This study reveals previously unrecognized effects of R-2HG on leukemia cells, providing insights into novel treatments for cancer.

MOLECULAR CELL (2021)

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Article Biotechnology & Applied Microbiology

METTL3 restrains papillary thyroid cancer neutrophil infiltration

Jing He et al.

Summary: The RNA modification N6-methyladenosine (m6A) plays a crucial role in papillary thyroid carcinoma (PTC) by regulating the tumor-suppressive effects of METTL3 on c-Rel and RelA. Additionally, METTL3 disruption leads to IL-8 secretion and altered recruitment of tumor-associated neutrophils (TANs), affecting tumor growth and metastasis.

MOLECULAR THERAPY (2021)

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Article Cell Biology

ALKBH5 suppresses tumor progression via an m6A-dependent epigenetic silencing of pre-miR-181b-1/YAP signaling axis in osteosarcoma

Ye Yuan et al.

Summary: ALKBH5 is the main enzyme responsible for m(6)A-based demethylation of RNAs and has been associated with various biological and pathophysiological processes. In osteosarcoma, downregulated levels of ALKBH5 were correlated with increased m(6)A methylation, leading to enhanced cancer progression. ALKBH5 overexpression suppressed osteosarcoma cell growth, migration, and invasion by regulating the m(6)A methylation of specific RNA molecules, suggesting a potential therapeutic approach for osteosarcoma treatment.

CELL DEATH & DISEASE (2021)

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Article Multidisciplinary Sciences

EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma

Runping Fang et al.

Summary: In this study, it was revealed that YTHDF2 overexpression is associated with poor prognosis in glioma patients due to EGFR-induced protein stabilization, leading to reduced cholesterol homeostasis and promoting GBM tumorigenesis through an RNA m6A methylation dependent mechanism.

NATURE COMMUNICATIONS (2021)

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Article Cell Biology

Long noncoding RNA NBAT1 suppresses hepatocellular carcinoma progression via competitively associating with IGF2BP1 and decreasing c-Myc expression

Ling Wei et al.

Summary: Hepatocellular Carcinoma (HCC) is the second leading cause of cancer-related deaths globally. NBAT1, a recently discovered lncRNA, has been found to be downregulated in HCC tissues and cells, and its overexpression can inhibit tumor growth by affecting the stability of c-Myc mRNA. These findings suggest that NBAT1 could serve as a potential therapeutic target for HCC treatment.

HUMAN CELL (2021)

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Article Cell Biology

Hypoxia blocks ferroptosis of hepatocellular carcinoma via suppression of METTL14 triggered YTHDF2-dependent silencing of SLC7A11

Zhuoyang Fan et al.

Summary: The study revealed that the suppression of METTL14 in HCC cells under hypoxic conditions weakens ferroptosis, with SLC7A11 identified as a direct target of METTL14 and functioning through the YHDF2-dependent pathway.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Article Biochemistry & Molecular Biology

The m(6)A reader YTHDC2 inhibits lung adenocarcinoma tumorigenesis by suppressing SLC7A11-dependent antioxidant function

Lifang Ma et al.

Summary: The m(6)A reader YTHDC2 is frequently suppressed in lung adenocarcinoma, leading to poor clinical outcomes, and it exerts antitumor activity by suppressing cystine uptake via system XE. Downregulation of YTHDC2 destabilizes SLC7A11 mRNA in an m(6)A-dependent manner, implicating the modulation of cystine uptake in promoting lung adenocarcinoma tumorigenesis.

REDOX BIOLOGY (2021)

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Article Genetics & Heredity

YTHDF2 Inhibits Gastric Cancer Cell Growth by Regulating FOXC2 Signaling Pathway

Xudong Shen et al.

Summary: YTHDF2, with lower expression in GC tissues and cells, inhibits the growth of gastric cancer cells and is closely related to patient survival and cancer stage. The study showed that YTHDF2 negatively regulates FOXC2 to inhibit GC cell growth.

FRONTIERS IN GENETICS (2021)

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Article Oncology

The m6A RNA Demethylase ALKBH5 Promotes Radioresistance and Invasion Capability of Glioma Stem Cells

Aline Kowalski-Chauvel et al.

Summary: The study found that the overexpression of m6A RNA demethylase ALKBH5 in GBMSCs increases their resistance to radiation and promotes their invasive ability by controlling homologous recombination. Therefore, inhibiting ALKBH5 may be an effective therapeutic approach to overcome the radioresistance and invasiveness of GBMSCs.

CANCERS (2021)

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Article Toxicology

N6-methyladenosine reader YTHDC2 and eraser FTO may determine hepatocellular carcinoma prognoses after transarterial chemoembolization

Jiandong Liu et al.

Summary: Transarterial chemoembolization (TACE) has improved overall survival of unresectable hepatocellular carcinoma (HCC) patients, but some show no response to TACE. Functional SNPs in m(6)A-regulating genes, particularly in YTHDC2 and FTO, were found to be associated with prognosis in TACE-treated HCC patients in a Chinese Han population. This suggests m(6)A-regulating genes could be potential targets to enhance therapeutic strategies for unresectable HCC patients.

ARCHIVES OF TOXICOLOGY (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Cell Biology

WTAP facilitates progression of endometrial cancer via CAV-1/NF-κB axis

Qin Li et al.

Summary: The high expression of WTAP in endometrial cancer leads to increased proliferation, migration, and invasion of cells, decreased apoptosis, and higher tumor malignancy. Knocking down WTAP in EC cells results in upregulation of CAV-1, decrease in m(6)A and METTL3 enrichment at the 3' -UTR of CAV-1, and inhibition of NF-kappa B signaling pathway activity.

CELL BIOLOGY INTERNATIONAL (2021)

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Article Cell Biology

Kinase GSK3β functions as a suppressor in colorectal carcinoma through the FTO-mediated MZF1/c-Myc axis

Zeyan Zhang et al.

Summary: The study found that GSK3 beta suppresses the progression of CRC through the FTO-regulated MZF1/c-Myc axis, providing a new possible pathway for CRC treatment.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Article Oncology

LINC00460/DHX9/IGF2BP2 complex promotes colorectal cancer proliferation and metastasis by mediating HMGA1 mRNA stability depending on m6A modification

Pingfu Hou et al.

Summary: The study found that LINC00460 is upregulated in CRC and high expression is associated with poor survival rates. LINC00460 interacts with IGF2BP2 and DHX9 to enhance the stability of HMGA1 mRNA through m6A modification, promoting cell proliferation, migration, and invasion in CRC.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Oncology

RBM15 facilitates laryngeal squamous cell carcinoma progression by regulating TMBIM6 stability through IGF2BP3 dependent

Xin Wang et al.

Summary: The study found a significant increase in global mRNA m6A methylation levels in patients with laryngeal squamous cell carcinoma (LSCC), highlighting the essential roles of RBM15 and IGF2BP3 in m6A methylation modification. This study identified a novel RNA regulatory mechanism in LSCC.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Oncology

HOXA10 mediates epithelial-mesenchymal transition to promote gastric cancer metastasis partly via modulation of TGFB2/Smad/METTL3 signaling axis

Chenlong Song et al.

Summary: Our study demonstrated that HOXA10 is upregulated in gastric cancer, especially in patients with lymph node metastasis. Functionally, HOXA10 promotes migration and invasion of gastric cancer cells, as well as accelerates lung metastasis in vivo. The EMT process mediated by the HOXA10/TGFB2/Smad/METTL3 signaling axis plays a crucial role in gastric cancer progression and metastasis.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Surgery

IGF2BP3 Expression Correlates With Poor Prognosis in Esophageal Squamous Cell Carcinoma

Akiyuki Wakita et al.

Summary: IGF2BP3 high expression in advanced thoracic esophageal squamous cell carcinoma is associated with poor clinical outcomes in patients treated with surgery alone, while there is no significant correlation in patients treated with surgery plus postoperative adjuvant chemotherapy.

JOURNAL OF SURGICAL RESEARCH (2021)

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Article Medicine, Research & Experimental

N-methyladenosine reader YTHDF2-mediated long noncoding RNA FENDRR degradation promotes cell proliferation in endometrioid endometrial carcinoma

Jie Shen et al.

Summary: Dysregulation of long noncoding RNA (LncRNA) FENDDR is closely related to cancer progression. This study reveals that the decreased expression and elevated m6A methylation levels of LncRNA FENDRR are associated with endometrioid endometrial carcinoma (EEC). YTHDF2-mediated degradation of LncRNA FENDRR promotes cell proliferation in EEC by increasing SOX4 expression.

LABORATORY INVESTIGATION (2021)

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Article Multidisciplinary Sciences

The RNA m6A reader YTHDC1 silences retrotransposons and guards ES cell identity

Jiadong Liu et al.

Summary: The study reveals that the m(6)A RNA modification and YTHDC1 play essential roles in regulating retrotransposons and cellular reprogramming during early mouse embryonic development.

NATURE (2021)

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Article Cell Biology

Aberrant activation of m6A demethylase FTO renders HIF2αlow/- clear cell renal cell carcinoma sensitive to BRD9 inhibitors

Chuanjie Zhang et al.

Summary: In research, it was found that the m6A demethylase FTO gene was essential for the growth of HIF2 alpha(low/-) ccRCC, and BRD9 was identified as a druggable target for treating HIF2 alpha(low/-) ccRCC with more efficacy than sunitinib.

SCIENCE TRANSLATIONAL MEDICINE (2021)

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Article Oncology

Interplay between RNA Methylation Eraser FTO and Writer METTL3 in Renal Clear Cell Carcinoma Patient Survival

Jiaxun Zhao et al.

Summary: The study found a significant negative correlation between mRNA and DNA methylation of FTO and METTL3, with better prognosis in CCRCC patients with high FTO mRNA or low DNA methylation, or low METTL3 mRNA or high DNA methylation. Dysregulated FTO and METTL3 may be involved in CCRCC disease development and progression, impacting immune response. FTO and METTL3 expression and DNA methylation could serve as potential prognostic markers for CCRCC.

RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY (2021)

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Article Medicine, Research & Experimental

METTL3-mediatedm6Amodification ofZBTB4mRNA is involved in the smoking-induced EMT in cancer of the lung

Cheng Cheng et al.

Summary: N6-methyladenosine (m(6)A) modification of ZBTB4 via EZH2, mediated by METTL3, is involved in cigarette smoke-induced epithelial-mesenchymal transition (EMT) and lung cancer. The higher expression of METTL3 in lung tissues of smokers is inversely correlated with ZBTB4 levels. These findings suggest that m(6)A modifications could be a potential therapeutic target for lung damage induced by cigarette smoke.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

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Article Chemistry, Multidisciplinary

PADI2-Catalyzed MEK1 Citrullination Activates ERK1/2 and Promotes IGF2BP1-Mediated SOX2 mRNA Stability in Endometrial Cancer

Teng Xue et al.

Summary: The study found that PADI2 plays a role in promoting the progression of endometrial cancer (EC) by facilitating the expression of IGF2BP1 and preventing SOX2 mRNA degradation. Inhibiting PADI2/MEK1 signaling could be a potential therapeutic approach for EC.

ADVANCED SCIENCE (2021)

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Article Genetics & Heredity

Construction and Comprehensive Analyses of a METTL5-Associated Prognostic Signature With Immune Implication in Lung Adenocarcinomas

Sijin Sun et al.

Summary: This study explored the multi-omics information in lung adenocarcinoma patients, revealing the significant correlation between high expression of METTL5 in LUAD and poor prognosis. The constructed MAPS could serve as a promising biomarker for LUAD.

FRONTIERS IN GENETICS (2021)

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Article Cell Biology

Methylation of microRNA-338-5p by EED promotes METTL3-mediated translation of oncogene CDCP1 in gastric cancer

Fangbin Zhang et al.

Summary: This study elucidated the role of EED, miR-338-5p, METTL3, and CDCP1 in gastric cancer, showing that EED promoted cancer progression by downregulating miR-338-5p through histone methylation, thereby enhancing CDCP1 translation and inhibiting METTL3 inhibition. The findings suggest potential novel targets for therapy in limiting the recurrence and metastasis of gastric cancer.

AGING-US (2021)

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Article Cell Biology

Circular RNA hsa_circ_0072309 promotes tumorigenesis and invasion by regulating the miR-607/FTO axis in non-small cell lung carcinoma

Wei-Lie Mo et al.

Aging-US (2021)

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Article Oncology

USP48 Is Upregulated by Mettl14 to Attenuate Hepatocellular Carcinoma via Regulating SIRT6 Stabilization

Lutao Du et al.

Summary: The study reveals that USP48 binds and stabilizes SIRT6 through K48-linked deubiquitination, inhibiting metabolic reprogramming and tumorigenesis in HCC. Additionally, Mettl14-induced m(6)A modification regulates USP48 and contributes to HCC by maintaining USP48 mRNA stability, highlighting the importance of metabolic activities in HCC treatment.

CANCER RESEARCH (2021)

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Article Oncology

Single-nucleotide polymorphism rs4142441 and MYC co-modulated long non-coding RNA OSER1-AS1 suppresses non-small cell lung cancer by sequestering ELAVL1

Weijia Xie et al.

Summary: The study identified a lncRNA called OSER1-AS1, which exhibited tumor-suppressive functions in lung cancer by inhibiting tumor growth and metastasis. It may serve as a potential therapeutic target and prognostic marker.

CANCER SCIENCE (2021)

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Article Medicine, Research & Experimental

METTL3-mediated m6A mRNA modification promotes esophageal cancer initiation and progression via Notch signaling pathway

Hui Han et al.

Summary: The study discovered that METTL3 is upregulated in esophageal cancer and promotes tumor progression, being associated with poor prognosis. High METTL3 expression can promote esophageal cancer formation by activating the Notch signaling pathway. The findings provide a molecular basis for the diagnosis and treatment of esophageal cancer.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

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Article Biochemistry & Molecular Biology

Targeting SLC3A2 subunit of system XC- is essential for m6A reader YTHDC2 to be an endogenous ferroptosis inducer in lung adenocarcinoma

Lifang Ma et al.

Summary: YTHDC2 induces ferroptosis in LUAD cells by inhibiting HOXA13 to suppress SLC3A2, along with SLC7A11, which are crucial for tumor growth inhibition and lipid peroxidation induced by YTHDC2.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

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Article Biochemistry & Molecular Biology

linc01305 promotes metastasis and proliferation of esophageal squamous cell carcinoma through interacting with IGF2BP2 and IGF2BP3 to stabilize HTR3A mRNA

Guo-Wei Huang et al.

Summary: The research discovers a novel mechanism where cytoplasmic linc01305 stabilizes HTR3A mRNA through interaction with IGF2BP2 and IGF2BP3, thereby promoting metastasis and proliferation of esophageal squamous cell carcinoma (ESCC).

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2021)

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Letter Oncology

HNRNPA2B1 promotes multiple myeloma progression by increasing AKT3 expression via m6A-dependent stabilization of ILF3 mRNA

Fengjie Jiang et al.

Summary: This study identified that HNRNPA2B1 is upregulated in multiple myeloma (MM) patients and negatively correlated with prognosis, playing a role in regulating cell proliferation by modulating AKT3 expression. This suggests that HNRNPA2B1 may act as a potential therapeutic target for MM through the ILF3-dependent pattern.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

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Article Medicine, Research & Experimental

The FTO m6A demethylase inhibits the invasion and migration of prostate cancer cells by regulating total m6A levels

Kai Zhu et al.

Summary: This study revealed that FTO is downregulated in prostate cancer, leading to an increase in m(6)A levels, and lower FTO expression is associated with advanced tumor stage and higher Gleason scores. FTO inhibits prostate cancer cell invasion and migration by decreasing the total m(6)A level.

LIFE SCIENCES (2021)

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Article Biochemistry & Molecular Biology

ALKBH5-mediated m6A demethylation of lncRNA RMRP plays an oncogenic role in lung adenocarcinoma

Hui Yu et al.

Summary: Lung adenocarcinomas have increased RMRP expression, which is associated with poor prognosis. ALKBH5 upregulates RMRP expression via demethylation, indicating that targeting RMRP through ALKBH5 manipulation could be a promising therapeutic strategy for lung adenocarcinoma.

MAMMALIAN GENOME (2021)

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Review Biochemistry & Molecular Biology

The m6A RNA methylation regulates oncogenic signaling pathways driving cell malignant transformation and carcinogenesis

Mohammad Burhan Uddin et al.

Summary: m(6)A RNA methylation is a prevalent internal modification in mammalian mRNAs, dysregulation of which is frequently observed in pathological conditions, particularly in cancer. Recent studies have shown that oncogenic signaling pathways in cancer are modulated by m(6)A modifications in target mRNAs and noncoding RNA transcripts.

MOLECULAR CANCER (2021)

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Article Biochemistry & Molecular Biology

CircPTPRA blocks the recognition of RNA N6-methyladenosine through interacting with IGF2BP1 to suppress bladder cancer progression

Fei Xie et al.

Summary: This study identifies circPTPRA as a novel tumor suppressor that inhibits cancer progression by blocking the recognition of IGF2BP1 to m(6)A-modified RNAs, suggesting circPTPRA may serve as a potential therapeutic target for patients with bladder cancer.

MOLECULAR CANCER (2021)

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Article Multidisciplinary Sciences

Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia

Eliza Yankova et al.

Summary: The study identified a highly potent and selective catalytic inhibitor of METTL3, STM2457, which shows potential therapeutic value in treating AML. Treatment with this inhibitor leads to reduced AML growth, increased differentiation and apoptosis, and decreased m(6)A levels on leukemogenic mRNAs. In vivo pharmacological inhibition of METTL3 results in impaired engraftment and prolonged survival in mouse models of AML.

NATURE (2021)

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Article Oncology

m6A demethylase RD induces NELL2 expression by inhibiting E2F1 m6A modification leading to metastasis of non-small cell lung cancer

Yanyun Wang et al.

Summary: The study found that E2F1 was highly expressed in NSCLC tissues and cells, enhancing the viability, migration, and invasion of NSCLC cells by transcriptionally activating NELL2. FTO upregulated the expression of E2F1 by inhibiting the m6A modification of E2F1, modulating the behavior of NSCLC cells.

MOLECULAR THERAPY-ONCOLYTICS (2021)

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Article Oncology

YTHDF1 Aggravates the Progression of Cervical Cancer Through m6A-Mediated Up-Regulation of RANBP2

Haocheng Wang et al.

Summary: The study demonstrated that YTHDF1 is highly expressed in cervical cancer and associated with poor prognosis, by regulating the expression of RANBP2 to exert its oncogenic role in cervical cancer.

FRONTIERS IN ONCOLOGY (2021)

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Article Oncology

METTL3 Promotes Esophageal Squamous Cell Carcinoma Metastasis Through Enhancing GLS2 Expression

Xiaoting Chen et al.

Summary: Recent studies have identified pleiotropic roles of METTL3 in tumor progression, but its specific role in esophageal squamous cell carcinoma (ESCC) is still unclear. Higher METTL3 expression in ESCC tissues was associated with poor prognosis, and it was shown to promote migration and invasion of ESCC cells by regulating GLS2. These findings suggest METTL3/GLS2 signaling as a potential therapeutic target for anti-metastatic strategies against ESCC.

FRONTIERS IN ONCOLOGY (2021)

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Article Oncology

被撤回的出版物: miRNA-193a-3p Regulates the AKT2 Pathway to Inhibit the Growth and Promote the Apoptosis of Glioma Cells by Targeting ALKBH5 (Retracted article. See vol. 11, 2021)

Yong Cui et al.

Summary: miR-193a-3p plays a crucial role in glioma cells by inhibiting tumor growth and promoting apoptosis through the suppression of ALKBH5 and AKT2 expression. The antitumor effects are mediated by the AKT2-induced intrinsic apoptosis signaling pathway.

FRONTIERS IN ONCOLOGY (2021)

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Article Andrology

The m6A methyltransferase METTL3 regulates autophagy and sensitivity to cisplatin by targeting ATG5 in seminoma

Hanfei Chen et al.

Summary: The research revealed that METTL3, through m6A methylation, enhances autophagy and chemoresistance in seminoma cells. ATG5 was identified as a potential target for METTL3-mediated autophagy promotion.

TRANSLATIONAL ANDROLOGY AND UROLOGY (2021)

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Article Oncology

AMD1 upregulates hepatocellular carcinoma cells stemness by FTO mediated mRNA demethylation

Xinyu Bian et al.

Summary: In hepatocellular carcinoma (HCC), high levels of AMD1 promote stemness in HCC cells through specific mechanisms, exacerbating the progression of HCC. Therefore, AMD1 holds promise as both a prognostic predictor and therapeutic target for HCC.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

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Article Cell Biology

N6-methyladenosine (m6A) methyltransferase KIAA1429 accelerates the gefitinib resistance of non-small-cell lung cancer

Jun Tang et al.

Summary: The study found that m(6)A methyltransferase KIAA1429 is highly expressed in gefitinib-resistant NSCLC and can accelerate resistance to gefitinib. Inhibiting KIAA1429 can suppress tumor growth in vivo.

CELL DEATH DISCOVERY (2021)

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Article Cell Biology

m6A demethylase ALKBH5 suppression contributes to esophageal squamous cell carcinoma progression

Dong Xiao et al.

Aging-US (2021)

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Article Cell Biology

METTL3-mediated m6A modification of KIF3C-mRNA promotes prostate cancer progression and is negatively regulated by miR-320d

Honggui Ma et al.

Aging-US (2021)

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Article Hematology

A critical role of nuclear m6A reader YTHDC1 in leukemogenesis by regulating MCM complex-mediated DNA replication

Yue Sheng et al.

Summary: YTHDC1 functions as a nuclear m(6)A reader in RNA metabolism regulation, with its overexpression shown in AML. Genetic deletion of Ythdc1 blocks AML development and maintenance, as well as LSCs self-renewal. YTHDC1 also plays a role in normal hematopoiesis and HSPC maintenance, with haploinsufficiency reducing LSCs self-renewal in vivo.

BLOOD (2021)

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Article Oncology

A positive-feedback loop between HBx and ALKBH5 promotes hepatocellular carcinogenesis

Siming Qu et al.

Summary: ALKBH5 is overexpressed in HBV-related HCC tissues and predicts poor prognosis. The increased ALKBH5 expression is induced by HBx-mediated H3K4me3 modification in a WDR5-dependent manner after HBV infection, leading to m(6)A demethylation of HBx mRNA and stabilization of HBx expression. Positive correlations between HBx and ALKBH5 were observed in HBV-HCC tissues, and targeting ALKBH5 may provide a potential way for HBV-HCC treatment.

BMC CANCER (2021)

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Article Oncology

METTL3 enhances the stability of MALAT1 with the assistance of HuR via m6A modification and activates NF-κB to promote the malignant progression of IDH-wildtype glioma

Yu-Zhou Chang et al.

Summary: The study confirmed the role of METTL3 in IDH-wildtype gliomas, promoting malignant progression by enhancing the stability of MALAT1.

CANCER LETTERS (2021)

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Article Oncology

M(6)A Demethylase ALKBH5 Regulates PD-L1 Expression and Tumor Immunoenvironment in Intrahepatic Cholangiocarcinoma

Xinyao Qiu et al.

Summary: This study identifies PD-L1 mRNA as a target of ALKBH5 and reveals a role for ALKBH5 in regulating the tumor immune microenvironment and immunotherapy efficacy. These findings suggest a new regulatory mechanism for PD-L1 involving mRNA epigenetic modification by ALKBH5, as well as a potential role for ALKBH5 in cancer immunotherapies.

CANCER RESEARCH (2021)

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Article Oncology

N6-methyladenosine-Mediated Upregulation of WTAPP1 Promotes WTAP Translation and Wnt Signaling to Facilitate Pancreatic Cancer Progression

Junge Deng et al.

Summary: This study reveals how aberrant m(6)A modification of the WTAPP1 pseudogene results in increased translation of its protein-coding counterpart to promote Wnt signaling, which contributes to pancreatic cancer progression.

CANCER RESEARCH (2021)

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Article Oncology

IGF2BP2 promotes the progression of colorectal cancer through a YAP-dependent mechanism

Jie Cui et al.

Summary: IGF2BP2 activates ErbB2 expression by recognizing the m6A modification of YAP, thus promoting proliferation and invasion of CRC cells while inhibiting apoptosis.

CANCER SCIENCE (2021)

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Article Cell Biology

CircPUM1 promotes cell growth and glycolysis in NSCLC via up-regulating METTL3 expression through miR-590-5p

Mingjun Li et al.

Summary: The study found that circPUM1 is highly expressed in NSCLC, and knocking it down can inhibit cell proliferation and glycolysis. MiR-590-5p can directly suppress the progression of NSCLC by regulating METTL3. CircPUM1 can regulate tumor growth and glycolysis in NSCLC through the miR-590-5p/METTL3 axis.

CELL CYCLE (2021)

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Article Biochemistry & Molecular Biology

YTHDC1-mediated augmentation of miR-30d in repressing pancreatic tumorigenesis via attenuation of RUNX1-induced transcriptional activation of Warburg effect

Yichao Hou et al.

Summary: The study demonstrates that miR-30d is downregulated in PDAC tissues, exerting tumor-suppressive effects by inhibiting tumor growth and metastasis, and reducing the Warburg effect through suppression of aerobic glycolysis. The m(6)A reader YTHDC1 facilitates the biogenesis of miR-30d by regulating mRNA stability. MiR-30d inhibits aerobic glycolysis by directly targeting the transcription factor RUNX1 and suppressing SLC2A1 and HK1 expression in PDAC.

CELL DEATH AND DIFFERENTIATION (2021)

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Article Dermatology

LncRNA MSC-AS1 motivates the development of melanoma by binding to miR-302a-3p and recruiting IGF2BP2 to elevate LEF1 expression

Yan Ma et al.

Summary: In this study, MSC-AS1 was found to be up-regulated in melanoma cells, inhibiting cell proliferation, migration, and epithelial-mesenchymal transition. MSC-AS1 was shown to regulate LEF1 expression by interfering with miR-302a-3p and recruiting IGF2BP2, suggesting MSC-AS1 as a potential biomarker in melanoma treatment.

EXPERIMENTAL DERMATOLOGY (2021)

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Article Cell Biology

CCAT2 enhances autophagy-related invasion and metastasis via regulating miR-4496 and ELAVL1 in hepatocellular carcinoma

Jing Shi et al.

Summary: The study found that lncRNA CCAT2 is significantly upregulated in HCC tissues, correlating with advanced stage and venous invasion. Further experiments revealed that CCAT2 induces autophagy and promotes migration and invasion in vitro and in vivo. Mechanistic investigations showed that CCAT2 regulates HCC by affecting miR-4496/Atg5 in the cytoplasm and binding with ELAVL1/HuR in the nucleus to facilitate HCC progression.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Article Medical Laboratory Technology

METTL3-mediated m6A methylation of ASPM drives hepatocellular carcinoma cells growth and metastasis

An Wang et al.

Summary: In this study, we found that ASPM was significantly upregulated in LIHC and its high expression was associated with poor prognosis. Knockdown of ASPM suppressed LIHC cell proliferation, migration, and invasion, while overexpression had the opposite effect. Mechanistically, we revealed that METTL3-mediated N6-methyladenosine modification of ASPM mRNA promoted its expression in LIHC. Silencing METTL3 also inhibited LIHC cell proliferation, migration, and invasion, but this effect could be rescued by overexpression of ASPM. These findings suggest that the METTL3/ASPM axis may be a promising therapeutic target for LIHC.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2021)

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Article Oncology

ALKBH5-HOXA10 loop-mediated JAK2 m6A demethylation and cisplatin resistance in epithelial ovarian cancer

Sipei Nie et al.

Summary: In this study, it was found that ALKBH5 is upregulated in cisplatin-resistant EOC and promotes cancer cell resistance to cisplatin. The ALKBH5-HOXA10 loop activates the JAK2/STAT3 signaling pathway, leading to EOC chemoresistance. Inhibition of the expression of the ALKBH5-HOXA10 loop may be a potential strategy to overcome cisplatin resistance in EOC.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Oncology

YTHDF2 facilitates UBXN1 mRNA decay by recognizing METTL3-mediated m6A modification to activate NE-κB and promote the malignant progression of glioma

Rui-Chao Chai et al.

Summary: YTHDF2 expression is positively associated with higher malignant grade and molecular subtype of glioma, and poorer prognosis. YTHDF2 promotes the malignant progression of gliomas by accelerating UBXN1 mRNA degradation via METTL3-mediated m(6)A modification, which in turn promotes NF-kappa B activation.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

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Article Oncology

Mapping of m6A and Its Regulatory Targets in Prostate Cancer Reveals a METTL3-Low Induction of Therapy Resistance

Kellie A. Cotter et al.

Summary: Recent evidence suggests that N-6-methyladenosine plays a significant role in cancer, particularly in prostate cancer where low levels of METTL3 are associated with advanced metastatic disease. METTL3 knockdown in prostate cancer cells leads to resistance to androgen receptor antagonists via a mechanism involving upregulation of nuclear receptor NR5A2/LRH-1.

MOLECULAR CANCER RESEARCH (2021)

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Article Biochemistry & Molecular Biology

ALKBH5-mediated m6A-demethylation of USP1 regulated T-cell acute lymphoblastic leukemia cell glucocorticoid resistance by Aurora B

Hongtao Gong et al.

Summary: Recent studies have shown that USP1 plays a crucial role in chemoresistance of T-ALL, and its expression level is closely related to patient prognosis. ALKBH5 regulates USP1 expression, affecting T-ALL cell sensitivity to dexamethasone and other biological functions.

MOLECULAR CARCINOGENESIS (2021)

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Article Biochemistry & Molecular Biology

Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer

Jaclyn M. Einstein et al.

Summary: RNA-binding proteins (RBPs) play crucial roles in post-transcriptional gene expression regulation, and disrupting YTHDF2-dependent mRNA degradation can induce apoptosis in triple-negative breast cancer (TNBC) cells and tumors. Our study identified 57 RBP candidates with distinct functions in supporting MYC-driven oncogenic pathways, highlighting the therapeutic potential of RBPs, especially YTHDF2, in counteracting global mRNA synthesis in MYC-driven breast cancers.

MOLECULAR CELL (2021)

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Review Oncology

Advancing therapy for osteosarcoma

Jonathan Gill et al.

Summary: Osteosarcoma, the most common primary bone cancer in children and young adults, presents challenges in treatment due to its rarity and molecular heterogeneity. Collaborative efforts in biological discoveries, technologies, and therapeutic approaches are expected to advance osteosarcoma treatment and improve patient outcomes. The increasing feasibility of molecular profiling, along with the creation of robust model systems and large tissue banks, has enhanced understanding of osteosarcoma biology.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

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Article Biochemistry & Molecular Biology

ALKBH5 Promotes the Proliferation of Glioma Cells via Enhancing the mRNA Stability of G6PD

Zhifeng Liu et al.

Summary: This study revealed that the upregulation of ALKBH5 in glioma promotes cell proliferation by demethylating G6PD and enhancing PPP activity. ALKBH5 could serve as a potential therapeutic target for glioma.

NEUROCHEMICAL RESEARCH (2021)

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Article Biochemistry & Molecular Biology

N6-methyladenosine demethylase ALKBH5 suppresses malignancy of esophageal cancer by regulating microRNA biogenesis and RAI1 expression

Pengxiang Chen et al.

Summary: The study revealed the critical role of ALKBH5 in miRNA biogenesis and offered new insights for developing treatment strategies in esophageal cancer.

ONCOGENE (2021)

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Article Pathology

IGF2BP2 knockdown suppresses thyroid cancer progression by reducing the expression of long non-coding RNA HAGLR

Liangpeng Dong et al.

Summary: IGF2BP2 was found to be highly expressed in thyroid cancer tissues, and its knockdown led to decreased HAGLR expression, thereby inhibiting cell proliferation, migration, invasion, inducing cell apoptosis, and cell cycle arrest in an m6A-dependent manner. This study provides potential diagnostic and therapeutic targets for thyroid cancer.

PATHOLOGY RESEARCH AND PRACTICE (2021)

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Article Cell & Tissue Engineering

IGF2BP1 Promotes the Liver Cancer Stem Cell Phenotype by Regulating MGAT5 mRNA Stability by m6A RNA Methylation

Yichun Yang et al.

Summary: This study elucidated the mechanism of action of IGF2BP1 on the phenotype of liver cancer stem cells (LCSCs). IGF2BP1 was found to promote self-renewal and chemoresistance in human LCSCs, enhance tumorigenesis in mice, and increase the expression of stemness genes in LCSCs. The study concluded that IGF2BP1 facilitated LCSC phenotypes by promoting the stability of MGAT5 mRNA through m6A modification.

STEM CELLS AND DEVELOPMENT (2021)

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Article Cell Biology

METTL14 promotes tumorigenesis by regulating lncRNA OIP5-AS1/miR-98/ADAMTS8 signaling in papillary thyroid cancer

Xiaoping Zhang et al.

Summary: The study reveals that OIP5-AS1 is a METTL14-regulated lncRNA that plays a crucial role in the progression of PTC, providing new insights into the regulatory mechanisms of PTC development.

CELL DEATH & DISEASE (2021)

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Article Multidisciplinary Sciences

METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N6-methyladenosine-dependent YTHDF binding

Wei Wang et al.

Summary: This study demonstrates that METTL3 downregulates APC by upregulating its m(6)A modification and recruiting YTHDF2 for APC mRNA degradation, leading to enhanced glycolysis and tumor growth in esophageal cancer.

NATURE COMMUNICATIONS (2021)

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Article Oncology

METTL3-dependent MALAT1 delocalization drives c-Myc induction in thymic epithelial tumors

Alessia Iaiza et al.

Summary: This study revealed that METTL3 contributes to the phenotype of Thymic Epithelial Tumors, with overexpression in tumor tissue compared to normal tissue. Silencing of METTL3 in thymic carcinoma cells resulted in decreased cell proliferation and overall translation rate. Furthermore, it was found that METTL3 is responsible for the induction of c-MYC expression in TET cells, with c-MYC protein expression enabled by lncRNA MALAT1 methylated and delocalized by METTL3. Blocking c-MYC with JQ1 inhibitor in combination with METTL3 depletion showed cooperation in inhibiting proliferation and inducing cell death.

CLINICAL EPIGENETICS (2021)

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Article Immunology

METTL3 Intensifies the Progress of Oral Squamous Cell Carcinoma via Modulating the m6A Amount of PRMT5 and PD-L1

Yilong Ai et al.

Summary: The study found that high METTL3 expression in oral squamous cell carcinoma (OSCC) is associated with poor prognosis. Knockdown of METTL3 reduced OSCC cell invasion, migration, and proliferation, while overexpression had the opposite effect. METTL3 modulates PRMT5 and PD-L1 m6A modification to promote metastasis and proliferation in OSCC.

JOURNAL OF IMMUNOLOGY RESEARCH (2021)

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Article Medicine, Research & Experimental

被撤回的出版物: m6A demethylase RD suppresses pancreatic cancer tumorigenesis by demethylating PJA2 and inhibiting Wnt signaling (Retracted article)

Juan Zeng et al.

Summary: The study found that reduced expression of the m6A demethylase FTO in pancreatic cancer led to higher levels of m6A RNA modification. FTO demethylated the m6A modification of PJA2, reducing its mRNA decay, suppressing Wnt signaling, and ultimately restraining the proliferation, invasion, and metastasis of pancreatic cancer cells. This provides new potential molecular therapeutic targets for pancreatic cancer.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

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Article Oncology

m6A methyltransferase METTL3-mediated lncRNA FOXD2-AS1 promotes the tumorigenesis of cervical cancer

Fei Ji et al.

Summary: The study found that FOXD2-AS1 is upregulated in cervical cancer and accelerates its progression via METTL3-mediated m(6)A modification. FOXD2-AS1 promotes cell migration and proliferation, highlighting its potential as a therapeutic target for cervical cancer.

MOLECULAR THERAPY-ONCOLYTICS (2021)

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Article Oncology

METTL3 increases cisplatin chemosensitivity of cervical cancer cells via downregulation of the activity of RAGE

Ruyi Li et al.

Summary: METTL3 overexpression in cervical cancer cells enhances sensitivity to cisplatin and inhibits tumor growth by downregulating RAGE expression.

MOLECULAR THERAPY-ONCOLYTICS (2021)

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Article Cell Biology

YTHDF1 Promotes Cyclin B1 Translation through m6A Modulation and Contributes to the Poor Prognosis of Lung Adenocarcinoma with KRAS/TP53 Co-Mutation

Xiaoying Lou et al.

Summary: Co-occurrence of KRAS and TP53 mutations is associated with poor prognosis in lung adenocarcinoma patients, potentially enhancing metastatic tendencies. Elevated expression of YTHDF1 was identified in patients with KRAS/TP53-mut and correlated with unfavorable prognosis, promoting translation of cyclin B1 mRNA in an m(6)A-dependent manner. The YTHDF1-m(6)A-cyclin B1 translation axis was confirmed as a crucial molecular pathway for the prognosis of KRAS/TP53-mut LUAD.

CELLS (2021)

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Article Oncology

The m6A Methyltransferase METTL14-Mediated N6-Methyladenosine Modification of PTEN mRNA Inhibits Tumor Growth and Metastasis in Stomach Adenocarcinoma

Qi Yao et al.

Summary: The study revealed that METTL14 is significantly downregulated in STAD and inhibits tumor growth and metastasis by stabilizing PTEN mRNA expression. METTL14 may serve as a potential prognostic and therapeutic target for STAD.

FRONTIERS IN ONCOLOGY (2021)

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Article Oncology

Long Non-Coding RNA CCAT2 Promotes the Development of Esophageal Squamous Cell Carcinoma by Inhibiting miR-200b to Upregulate the IGF2BP2/TK1 Axis

Xiaodan Wu et al.

Summary: In this study, CCAT2 was identified as an important lncRNA in esophageal squamous cell carcinoma (ESCC), which competitively binds to miR-200b to upregulate IGF2BP2 and TK1 expression, promoting the development of ESCC.

FRONTIERS IN ONCOLOGY (2021)

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Article Oncology

Knockdown of m6A Reader IGF2BP3 Inhibited Hypoxia-Induced Cell Migration and Angiogenesis by Regulating Hypoxia Inducible Factor-1α in Stomach Cancer

Libin Jiang et al.

Summary: IGF2BP3 regulates hypoxia-induced cell migration and angiogenesis in stomach cancer by directly binding to HIF1A mRNA and positively regulating its expression.

FRONTIERS IN ONCOLOGY (2021)

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Article Oncology

METTL3 Promotes the Resistance of Glioma to Temozolomide via Increasing MGMT and ANPG in a m(6)A Dependent Manner

Jia Shi et al.

Summary: The study found that METTL3-mediated m(6)A modification was significantly elevated in TMZ-resistant GBM cells, impairing TMZ-sensitivity. Manipulation of METTL3 expression or methylation inhibition improved the sensitivity of TMZ-resistant GBM cells. Additionally, METTL3-modified DNA repair genes play a crucial role in GBM resistance to TMZ.

FRONTIERS IN ONCOLOGY (2021)

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Article Oncology

m6A Methyltransferase METTL14-Mediated Upregulation of Cytidine Deaminase Promoting Gemcitabine Resistance in Pancreatic Cancer

Congjun Zhang et al.

Summary: The study revealed that METTL14 plays a crucial role in gemcitabine resistance in pancreatic cancer, and inhibition of METTL14 can increase the sensitivity of resistant cells to gemcitabine. Transcription factor p65 targets and upregulates METTL14 expression, leading to increased expression of cytidine deaminase (CDA) which inactivates gemcitabine. Depletion of METTL14 restores the response of resistant cells to gemcitabine in a xenograft model.

FRONTIERS IN ONCOLOGY (2021)

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Article Oncology

N6-Methyladenosine RNA Demethylase FTO Promotes Gastric Cancer Metastasis by Down-Regulating the m6A Methylation of ITGB1

Duo Wang et al.

Summary: This study comprehensively analyzed the prognostic value of all 33 m6A RNA methylation regulators in GC, identifying fat mass and obesity-associated protein (FTO) as a key prognostic factor for overall survival (OS) of GC patients. FTO was found to promote GC metastasis by upregulating the expression of Integrin beta 1(ITGB1) via decreasing its m6A level.

FRONTIERS IN ONCOLOGY (2021)

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Article Cell Biology

HNRNPA2B1 Affects the Prognosis of Esophageal Cancer by Regulating the miR-17-92 Cluster

Kexin Li et al.

Summary: The study revealed that the dynamic changes in 25 m6A regulators were associated with the clinical features and prognosis of patients with esophageal cancer, with HNRNPA2B1 possibly affecting the prognosis of esophageal cancer patients by regulating the miR-17-92 cluster.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Oncology

METTL3-induced UCK2 m6A hypermethylation promotes melanoma cancer cell metastasis via the WNT/β-catenin pathway

Hao Wu et al.

Summary: The study found that the up-regulation of UCK2 in melanoma may play a crucial role and be associated with poor survival. The m(6)A modification regulated by METTL3 leads to increased mRNA stability of UCK2 in melanoma cancer. Functional and mechanistic experiments indicate that UCK2 enhances the metastasis of melanoma cancer cells through the WNT/β-catenin pathway.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

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Article Oncology

m6A modification of lncRNA PCAT6 promotes bone metastasis in prostate cancer through IGF2BP2-mediated IGF1R mRNA stabilization

Chuandong Lang et al.

Summary: This study uncovers a novel molecular mechanism involving the m(6)A-induced PCAT6/IGF2BP2/IGF1R axis in promoting PCa bone metastasis and tumor growth, suggesting that PCAT6 may serve as a promising prognostic marker and therapeutic target for bone-metastatic PCa.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

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Article Medicine, Research & Experimental

Circular RNA circRHOBTB3 represses metastasis by regulating the HuR-mediated mRNA stability of PTBP1 in colorectal cancer

Jiaxin Chen et al.

Summary: circRHOBTB3 is downregulated in colorectal cancer tissues and cell lines, overexpression of circRHOBTB3 suppresses tumor metastasis through the HuR/PTBP1 axis in CRC.

THERANOSTICS (2021)

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Article Mathematical & Computational Biology

Analysis of the role of METTL5 as a hub gene in lung adenocarcinoma based on a network

Xinwang Yan et al.

Summary: The study identified METTL5 as a potential key player in the occurrence and malignant progression of LUAD, with high expression of METTL5 linked to poor prognosis in LUAD patients. This provides an effective molecular target for early diagnosis of LUAD and may help improve patient outcomes.

MATHEMATICAL BIOSCIENCES AND ENGINEERING (2021)

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Article Oncology

YTHDF1 and YTHDF2 are associated with better patient survival and an inflamed tumor-immune microenvironment in non-small-cell lung cancer

Kazuo Tsuchiya et al.

Summary: The study found that high expressions of both YTHDF1 and YTHDF2 are associated with a favorable prognostic outcome of NSCLC patients, a greater amount of TILs, and downregulation of PD-L1. These two proteins may be novel prognostic and druggable targets related to the tumor-immune microenvironment in lung cancers.

ONCOIMMUNOLOGY (2021)

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Article Medicine, Research & Experimental

Silencing of METTL3 effectively hinders invasion and metastasis of prostate cancer cells

Yabing Chen et al.

Summary: The study found that METTL3 plays a crucial role in regulating invasion and metastasis of prostate cancer cells, offering potential therapeutic strategies for hindering the progression of PCa. By controlling the expression and regulation of specific genes, it may be possible to impede the malignant development of prostate cancer.

THERANOSTICS (2021)

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Article Biochemistry & Molecular Biology

Downregulation of m6A Reader YTHDC2 Promotes the Proliferation and Migration of Malignant Lung Cells via CYLD/NF-κB Pathway

Jin Wang et al.

Summary: This study highlighted the crucial role of YTHDC2 in the occurrence and progression of lung cancer, with its overexpression inhibiting the proliferation and migration of lung cancer cells, and its low expression being closely associated with poor outcomes.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Article Biotechnology & Applied Microbiology

Fat mass and obesity-associated protein (FTO) mediates signal transducer and activator of transcription 3 (STAT3)-drived resistance of breast cancer to doxorubicin

Yan Wang et al.

Summary: In doxorubicin-resistant breast cancer cells, FTO and STAT3 were highly expressed; FTO activated STAT3 signaling by regulating N6-methyladenosine (m6A) levels; FTO was implicated in STAT3-mediated doxorubicin resistance and impairment of doxorubicin sensitivity.

BIOENGINEERED (2021)

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Article Oncology

Longnon-coding RNA BLACAT2 promotes gastric cancer progression via the miR-193b-5p/METTL3 pathway

Hao Hu et al.

Summary: Research has shown that the long non-coding RNA BLACAT2 is significantly upregulated in gastric cancer and plays a promoting role in gastric cancer progression through interaction with miR-193b-5p. This interaction affects cell proliferation, migration, invasion, and apoptosis. Additionally, the downstream target of BLACAT2, METTL3, has been found to have a significant impact on the development of gastric cancer.

JOURNAL OF CANCER (2021)

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Article Biochemistry & Molecular Biology

HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation

Qing Li et al.

Summary: YTHDF1 plays a key role in hepatocellular carcinoma, with its expression level correlated to hypoxia-induced autophagy, tumor growth, and metastasis, serving as an independent prognostic factor. HIF-1 alpha regulates YTHDF1 transcription under hypoxia to promote translation of autophagy-related genes, contributing to autophagy and malignancy in HCC progression.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Letter Biochemistry & Molecular Biology

Knockdown of RNA N6-methyladenosine methyltransferase METTL3 represses Warburg effect in colorectal cancer via regulating HIF-1α

Zhou Yang et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Biochemistry & Molecular Biology

The role of m6A modification in the biological functions and diseases

Xiulin Jiang et al.

Summary: This paper highlights the importance of m6A RNA modification in eukaryotic RNA, including the roles of m6A methyltransferases, demethylases, and binding proteins. It emphasizes the crucial role of m6A RNA modification in the development of human cancers and discusses its impact on the physiological and pathological progressions of hematopoietic, central nervous, and reproductive systems.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Medicine, Research & Experimental

Circular RNA circDLC1 inhibits MMP1-mediated liver cancer via interaction with HuR

Hailing Liu et al.

Summary: Our study demonstrates that circDLC1 is downregulated in HCC tissues and is closely associated with a favorable prognosis. Overexpression of circDLC1 inhibits proliferation and motility of hepatoma cells, while silencing of circDLC1 has the opposite effect. Mechanistically, circDLC1 binds to RNA-binding protein HuR, reducing the interaction between HuR and MMP1 mRNA, leading to inhibition of MMP1 expression and ultimately suppressing HCC progression.

THERANOSTICS (2021)

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Article Medicine, Research & Experimental

IGF2BP1 overexpression stabilizes PEG10 mRNA in an m6A-dependent manner and promotes endometrial cancer progression

Lin Zhang et al.

Summary: This study reveals a crucial role of IGF2BP1 in the m(6)A-dependent regulatory mechanism in endometrial cancer, shedding light on disease progression and potential biological functions.

THERANOSTICS (2021)

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Article Cell Biology

m6A mRNA methylation controls autophagy and adipogenesis by targeting Atg5 and Atg7

Xinxia Wang et al.

AUTOPHAGY (2020)

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Article Genetics & Heredity

N6-methyladenosine METTL3 promotes the breast cancer progression via targeting Bcl-2

Hong Wang et al.

GENE (2020)

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Article Oncology

ALKBH5 Holds Prognostic Values and Inhibits the Metastasis of Colon Cancer

Peipei Yang et al.

PATHOLOGY & ONCOLOGY RESEARCH (2020)

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Article Gastroenterology & Hepatology

METTL3-mediated m6A modification of HDGF mRNA promotes gastric cancer progression and has prognostic significance

Qiang Wang et al.

GUT (2020)

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Article Biotechnology & Applied Microbiology

LINC00467 promotes cell proliferation and metastasis by binding with IGF2BP3 to enhance the mRNA stability of TRAF5 in hepatocellular carcinoma

Wenjin Jiang et al.

JOURNAL OF GENE MEDICINE (2020)

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Article Biotechnology & Applied Microbiology

被撤回的出版物: METTL14 Suppresses CRC Progression via Regulating N6-Methyladenosine-Dependent Primary miR-375 Processing (Retracted article. See vol. 30, pg. 2640, 2022)

Xiaoxiang Chen et al.

MOLECULAR THERAPY (2020)

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Article Biochemistry & Molecular Biology

DDX3 modulates cisplatin resistance in OSCC through ALKBH5-mediated m6A-demethylation of FOXM1 and NANOG

Omprakash Shriwas et al.

APOPTOSIS (2020)

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Article Biochemistry & Molecular Biology

ALKBH5-m6A-FOXM1 signaling axis promotes proliferation and invasion of lung adenocarcinoma cells under intermittent hypoxia

Yinghui Chao et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

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Article Biochemistry & Molecular Biology

The m6A methyltransferase METTL3 contributes to Transforming Growth Factor-beta-induced epithelial-mesenchymal transition of lung cancer cells through the regulation of JUNB

Sasithorn Wanna-udom et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

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Article Urology & Nephrology

The N6-methyladenosine (m6A) erasers alkylation repair homologue 5 (ALKBH5) and fat mass and obesity-associated protein (FTO) are prognostic biomarkers in patients with clear cell renal carcinoma

Alexander Strick et al.

BJU INTERNATIONAL (2020)

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Article Oncology

ALKBH5-mediated m6A demethylation of lncRNA PVT1 plays an oncogenic role in osteosarcoma

Shuo Chen et al.

CANCER CELL INTERNATIONAL (2020)

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Review Biochemistry & Molecular Biology

High-throughput approaches to profile RNA-protein interactions

Misha Nechay et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2020)

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Article Genetics & Heredity

N6-methyladenosine ALKBH5 promotes non-small cell lung cancer progress by regulating TIMP3 stability

Zhiyuan Zhu et al.

GENE (2020)

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Article Cell Biology

METTL3/YTHDF2 m6A axis promotes tumorigenesis by degrading SETD7 and KLF4 mRNAs in bladder cancer

Haiyun Xie et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Article Biochemistry & Molecular Biology

ZEB1 induced-upregulation of long noncoding RNA ZEB1-AS1 facilitates the progression of triple negative breast cancer by binding with ELAVL1 to maintain the stability of ZEB1 mRNA

Na Luo et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2020)

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Article Cell Biology

KIAA1429 regulates cell proliferation by targeting c-Jun messenger RNA directly in gastric cancer

Ran Miao et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

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Article Biochemistry & Molecular Biology

m6A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling

Bo Tang et al.

MOLECULAR CANCER (2020)

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Article Biochemistry & Molecular Biology

METTL14 suppresses proliferation and metastasis of colorectal cancer by down-regulating oncogenic long non-coding RNA XIST

Xiao Yang et al.

MOLECULAR CANCER (2020)

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Article Biochemistry & Molecular Biology

m6A demethylase ALKBH5 inhibits tumor growth and metastasis by reducing YTHDFs-mediated YAP expression and inhibiting miR-107/LATS2-mediated YAP activity in NSCLC

Dan Jin et al.

MOLECULAR CANCER (2020)

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Article Multidisciplinary Sciences

N6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription

Jun Liu et al.

SCIENCE (2020)

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Article Biotechnology & Applied Microbiology

FTO Facilitates Lung Adenocarcinoma Cell Progression by Activating Cell Migration Through mRNA Demethylation

Yudi Ding et al.

ONCOTARGETS AND THERAPY (2020)

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Article Oncology

METTL3 Promotes the Progression of Gastric Cancer via Targeting the MYC Pathway

Dong-Dong Yang et al.

FRONTIERS IN ONCOLOGY (2020)

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Article Biochemistry & Molecular Biology

m6A-dependent up-regulation of DRG1 by METTL3 and ELAVL1 promotes growth, migration, and colony formation in osteosarcoma

Zhian Ling et al.

BIOSCIENCE REPORTS (2020)

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Review Oncology

m6A Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer

Huilin Huang et al.

CANCER CELL (2020)

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Article Cell & Tissue Engineering

Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis

Jiazhen Wang et al.

CELL STEM CELL (2020)

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Article Cell & Tissue Engineering

RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia

Chao Shen et al.

CELL STEM CELL (2020)

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Article Cell Biology

m6A demethylase ALKBH5 promotes proliferation of esophageal squamous cell carcinoma associated with poor prognosis

Yushi Nagaki et al.

GENES TO CELLS (2020)

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Article Biochemistry & Molecular Biology

Downregulation of METTL14 increases apoptosis and autophagy induced by cisplatin in pancreatic cancer cells

Fanhua Kong et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2020)

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Article Cell Biology

Prognostic values of YTHDF1 regulated negatively by mir-3436 in Glioma

Chenyang Xu et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Article Cell Biology

LncRNA SOX2OT promotes temozolomide resistance by elevating SOX2 expression via ALKBH5-mediated epigenetic regulation in glioblastoma

Boyang Liu et al.

CELL DEATH & DISEASE (2020)

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Article Biochemistry & Molecular Biology

RNA demethylase ALKBH5 prevents pancreatic cancer progression by posttranscriptional activation of PER1 in an m6A-YTHDF2-dependent manner

Xingya Guo et al.

MOLECULAR CANCER (2020)

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Review Biochemistry & Molecular Biology

The potential role of RNA N6-methyladenosine in Cancer progression

Tianyi Wang et al.

MOLECULAR CANCER (2020)

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Article Oncology

ALKBH5 promotes the proliferation of renal cell carcinoma by regulating AURKB expression in an m(6)A-dependent manner

Xiaolei Zhang et al.

ANNALS OF TRANSLATIONAL MEDICINE (2020)

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Article Pharmacology & Pharmacy

METTL3 regulates the malignancy of cervical cancer via post-transcriptional regulation of RAB2B

Yingying Hu et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

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Article Oncology

Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion

Rui Su et al.

CANCER CELL (2020)

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Article Oncology

Long non-coding RNA CTBP1-AS2 enhances cervical cancer progression via up-regulation of ZNF217 through sponging miR-3163

Shanshan Yang et al.

CANCER CELL INTERNATIONAL (2020)

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Article Biochemistry & Molecular Biology

A Unified Model for the Function of YTHDF Proteins in Regulating m6A-Modified mRNA

Sara Zaccara et al.

CELL (2020)

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Article Medicine, Research & Experimental

METTL3 Facilitates Oral Squamous Cell Carcinoma Tumorigenesis by Enhancing c-Myc Stability via YTHDF1-Mediated m6A Modification

Wei Zhao et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

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Article Oncology

Angustoline Inhibited Esophageal Tumors Through Regulating LKB1/AMPK/ELAVL1/LPACT2 Pathway and Phospholipid Remodeling

Huiying Li et al.

FRONTIERS IN ONCOLOGY (2020)

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Article Oncology

Reduced Expression ofMETTL3Promotes Metastasis of Triple-Negative Breast Cancer by m6A Methylation-MediatedCOL3A1Up-Regulation

Yu Shi et al.

FRONTIERS IN ONCOLOGY (2020)

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Article Oncology

m6A Reader YTHDC2 Promotes Radiotherapy Resistance of Nasopharyngeal Carcinoma via Activating IGF1R/AKT/S6 Signaling Axis

Jun-Ju He et al.

FRONTIERS IN ONCOLOGY (2020)

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Article Cell Biology

HBXIP promotes gastric cancer via METTL3-mediated MYC mRNA m6A modification

Zhi Yang et al.

Aging-US (2020)

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Article Medicine, Research & Experimental

UpregulatedMETTL3in nasopharyngeal carcinoma enhances the motility of cancer cells

Zhi-Feng Liu et al.

KAOHSIUNG JOURNAL OF MEDICAL SCIENCES (2020)

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Article Biochemistry & Molecular Biology

METTL14-mediated N6-methyladenosine modification of SOX4 mRNA inhibits tumor metastasis in colorectal cancer

Xiaoxiang Chen et al.

MOLECULAR CANCER (2020)

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Article Biochemistry & Molecular Biology

ALKBH5 suppresses malignancy of hepatocellular carcinoma via m6A-guided epigenetic inhibition of LYPD1

Yunhao Chen et al.

MOLECULAR CANCER (2020)

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Article Genetics & Heredity

N6-Methyladenosine co-transcriptionally directs the demethylation of histone H3K9me2

Yuan Li et al.

NATURE GENETICS (2020)

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Article Biochemistry & Molecular Biology

M6A Demethylase FTO Plays a Tumor Suppressor Role in Thyroid Cancer

Run Tian et al.

DNA AND CELL BIOLOGY (2020)

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Article Cell Biology

m6A methyltransferase METTL3 promotes retinoblastoma progression via PI3K/AKT/mTOR pathway

Han Zhang et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Article Cell Biology

IGF2BP3 facilitates cell proliferation and tumorigenesis via modulation of JAK/STAT signalling pathway in human bladder cancer

Wei Huang et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Article Oncology

RNA N6-methyladenosine reader IGF2BP3 regulates cell cycle and angiogenesis in colon cancer

Zhou Yang et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

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Review Oncology

Roles of METTL3 in cancer: mechanisms and therapeutic targeting

Chengwu Zeng et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

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Article Medicine, Research & Experimental

Connecting METTL3 and intratumoural CD33+ MDSCs in predicting clinical outcome in cervical cancer

Huan-he Ni et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

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Article Medicine, General & Internal

Gastric cancer

Elizabeth C Smyth et al.

LANCET (2020)

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Article Biochemistry & Molecular Biology

Upregulation of METTL14 mediates the elevation ofPERPmRNA N6adenosine methylation promoting the growth and metastasis of pancreatic cancer

Min Wang et al.

MOLECULAR CANCER (2020)

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Article Pathology

METTL3 promotes the proliferation and invasion of esophageal cancer cells partly through AKT signaling pathway

Huaying Hou et al.

PATHOLOGY RESEARCH AND PRACTICE (2020)

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Article Cell Biology

N6-methyladenosine METTL3 promotes cervical cancer tumorigenesis and Warburg effect through YTHDF1/HK2 modification

Qianqing Wang et al.

CELL DEATH & DISEASE (2020)

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Article Reproductive Biology

YTHDF2, a protein repressed by miR-145, regulates proliferation, apoptosis, and migration in ovarian cancer cells

Jie Li et al.

JOURNAL OF OVARIAN RESEARCH (2020)

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Article Oncology

Downregulation ofm6AreaderYTHDC2promotes tumor progression and predicts poor prognosis in non-small cell lung cancer

Shulei Sun et al.

THORACIC CANCER (2020)

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Article Medicine, Research & Experimental

YTHDF1 Facilitates the Progression of Hepatocellular Carcinoma by Promoting FZD5 mRNA Translation in an m6A-Dependent Manner

Xiangxiang Liu et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

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Article Oncology

The FTO/miR-181b-3p/ARL5B signaling pathway regulates cell migration and invasion in breast cancer

Yuanyuan Xu et al.

CANCER COMMUNICATIONS (2020)

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Article Oncology

YTHDF3 Induces the Translation of m6A-Enriched Gene Transcripts to Promote Breast Cancer Brain Metastasis

Guoqiang Chang et al.

CANCER CELL (2020)

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Review Medicine, General & Internal

Endometrial Cancer

Karen H. Lu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Cell Biology

Ribosome 18S m6A Methyltransferase METTL5 Promotes Translation Initiation and Breast Cancer Cell Growth

Bowen Rong et al.

CELL REPORTS (2020)

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Article Oncology

METTL14 Inhibits Hepatocellular Carcinoma Metastasis Through Regulating EGFR/PI3K/AKT Signaling Pathway in an m6A-Dependent Manner

Yuntao Shi et al.

CANCER MANAGEMENT AND RESEARCH (2020)

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Article Oncology

Analysis of N6-Methyladenosine Methyltransferase Reveals METTL14 and ZC3H13 as Tumor Suppressor Genes in Breast Cancer

Peng-Ju Gong et al.

FRONTIERS IN ONCOLOGY (2020)

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Article Biochemistry & Molecular Biology

Identification and Validation of the N6-Methyladenosine RNA Methylation Regulator YTHDF1 as a Novel Prognostic Marker and Potential Target for Hepatocellular Carcinoma

Saiyan Bian et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2020)

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Article Oncology

Loading MicroRNA-376c in Extracellular Vesicles Inhibits Properties of Non-Small Cell Lung Cancer Cells by Targeting YTHDF1

Jianying Zhou et al.

TECHNOLOGY IN CANCER RESEARCH & TREATMENT (2020)

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Article Oncology

microRNA-96 promotes occurrence and progression of colorectal cancer via regulation of the AMPKα2-FTO-m6A/MYC axis

Caifeng Yue et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

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Article Oncology

IGF2BP2 Promotes Liver Cancer Growth Through an m6A-FEN1-Dependent Mechanism

Jian Pu et al.

FRONTIERS IN ONCOLOGY (2020)

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Review Medicine, General & Internal

Head and Neck Cancer

Laura Q. M. Chow

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Oncology

ALKBH5 regulates IGF1R expression to promote the Proliferation and Tumorigenicity of Endometrial Cancer

Xiaowen Pu et al.

JOURNAL OF CANCER (2020)

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Article Oncology

Upregulation of miR-324-5p Inhibits Proliferation and Invasion of Colorectal Cancer Cells by Targeting ELAVL1

Chijiang Gu et al.

ONCOLOGY RESEARCH (2019)

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Article Biochemistry & Molecular Biology

The m6A demethylase FTO promotes the growth of lung cancer cells by regulating the m6A level of USP7 mRNA

Jie Li et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

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Article Oncology

YTHDF2 suppresses cell proliferation and growth via destabilizing the EGFR mRNA in hepatocellular carcinoma

Li Zhong et al.

CANCER LETTERS (2019)

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Review Oncology

The Critical Role of RNA m6A Methylation in Cancer

Qing Lan et al.

CANCER RESEARCH (2019)

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Review Medicine, General & Internal

Epithelial ovarian cancer

Stephanie Lheureux et al.

LANCET (2019)

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Article Biochemistry & Molecular Biology

RNA N6-methyladenosine demethylase FTO promotes breast tumor progression updates through inhibiting BNIP3

Yi Niu et al.

MOLECULAR CANCER (2019)

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Article Oncology

miR-600 inhibits lung cancer via downregulating the expression of METTL3

Wenwen Wei et al.

CANCER MANAGEMENT AND RESEARCH (2019)

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Article Medicine, General & Internal

Blockade of miR-3614 maturation by IGF2BP3 increases TRIM25 expression and promotes breast cancer cell proliferation

Zhenzhen Wang et al.

EBIOMEDICINE (2019)

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Article Biochemistry & Molecular Biology

LBX2-AS1 is activated by ZEB1 and promotes the development of esophageal squamous cell carcinoma by interacting with HNRNPC to enhance the stability of ZEB1 and ZEB2 mRNAs

Yanshan Zhang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

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Article Oncology

Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia

Yue Huang et al.

CANCER CELL (2019)

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Article Oncology

A novel, liver-specific long noncoding RNA LINC01093 suppresses HCC progression by interaction with IGF2BP1 to facilitate decay of GLI1 mRNA

Jia He et al.

CANCER LETTERS (2019)

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Article Multidisciplinary Sciences

Excessive miR-25-3p maturation via N6-methyladenosine stimulated by cigarette smoke promotes pancreatic cancer progression

Jialiang Zhang et al.

NATURE COMMUNICATIONS (2019)

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Article Oncology

Downregulation of Fat Mass and Obesity Associated (FTO) Promotes the Progression of Intrahepatic Cholangiocarcinoma

Zhuo-Xian Rong et al.

FRONTIERS IN ONCOLOGY (2019)

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Article Chemistry, Analytical

Determination of RNA Hydroxylmethylation in Mammals by Mass Spectrometry Analysis

Xue-Jiao You et al.

ANALYTICAL CHEMISTRY (2019)

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Article Biochemical Research Methods

FunDMDeep-m6A: identification and prioritization of functional differential m6A methylation genes

Song-Yao Zhang et al.

BIOINFORMATICS (2019)

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Article Biochemistry & Molecular Biology

Deciphering the m6A Code via Antibody-Independent Quantitative Profiling

Miguel Angel Garcia-Campos et al.

CELL (2019)

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Article Biochemistry & Molecular Biology

ALKBH5 promotes invasion and metastasis of gastric cancer by decreasing methylation of the lncRNA NEAT1

Jun Zhang et al.

JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY (2019)

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Article Biochemistry & Molecular Biology

METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner

Jie Han et al.

MOLECULAR CANCER (2019)

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Article Biochemistry & Molecular Biology

RNAmod: an integrated system for the annotation of mRNA modifications

Qi Liu et al.

NUCLEIC ACIDS RESEARCH (2019)

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Article Biochemistry & Molecular Biology

KIAA1429 acts as an oncogenic factor in breast cancer by regulating CDK1 in an N6-methyladenosine-independent manner

Jia-Yi Qian et al.

ONCOGENE (2019)

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Article Biotechnology & Applied Microbiology

m6A methyltransferase METTL3 suppresses colorectal cancer proliferation and migration through p38/ERK pathways

Ru Deng et al.

ONCOTARGETS AND THERAPY (2019)

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Article Multidisciplinary Sciences

m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade

Seungwon Yang et al.

NATURE COMMUNICATIONS (2019)

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Article Multidisciplinary Sciences

Single-base mapping of m6A by an antibody-independent method

Zhang Zhang et al.

SCIENCE ADVANCES (2019)

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Article Biochemistry & Molecular Biology

WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1

Yunhao Chen et al.

MOLECULAR CANCER (2019)

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Article Pathology

The RNA m6A methyltransferase METTL3 promotes pancreatic cancer cell proliferation and invasion

Tianfang Xia et al.

PATHOLOGY RESEARCH AND PRACTICE (2019)

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Article Biotechnology & Applied Microbiology

WTAP is a prognostic marker of high-grade serous ovarian cancer and regulates the progression of ovarian cancer cells

Hai-Lan Yu et al.

ONCOTARGETS AND THERAPY (2019)

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Article Biochemistry & Molecular Biology

MiR-4429 prevented gastric cancer progression through targeting METTL3 to inhibit m6A-caused stabilization of SEC62

Huabo He et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

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Review Oncology

The interplay between m6A RNA methylation and noncoding RNA in cancer

Shuai Ma et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

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Article Biochemistry & Molecular Biology

METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer

Ben Yue et al.

MOLECULAR CANCER (2019)

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Article Biochemistry & Molecular Biology

Long noncoding RNA GAS5 inhibits progression of colorectal cancer by interacting with and triggering YAP phosphorylation and degradation and is negatively regulated by the m6A reader YTHDF3

Wen Ni et al.

MOLECULAR CANCER (2019)

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Article Biochemistry & Molecular Biology

Mettl14 inhibits bladder TIC self-renewal and bladder tumorigenesis through N6-methyladenosine of Notch1

Chaohui Gu et al.

MOLECULAR CANCER (2019)

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Article Biochemistry & Molecular Biology

YTHDF2 reduction fuels inflammation and vascular abnormalization in hepatocellular carcinoma

Jiajie Hou et al.

MOLECULAR CANCER (2019)

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Article Biotechnology & Applied Microbiology

RNA m6A Methyltransferase METTL3 Promotes The Growth Of Prostate Cancer By Regulating Hedgehog Pathway

Jiarong Cai et al.

ONCOTARGETS AND THERAPY (2019)

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被撤回的出版物: MicroRNA-139-3p Inhibits The Growth And Metastasis Of Ovarian Cancer By Inhibiting ELAVL1 (Retracted article. See vol. 15, pg. 839, 2022)

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