4.6 Article

Genistein Sensitizes Human Cholangiocarcinoma Cell Lines to Be Susceptible to Natural Killer Cells

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Medicine, Research & Experimental

Doxorubicin sensitizes breast cancer cells to natural killer cells in connection with increased Fas receptors

Nunghathai Sawasdee et al.

Summary: This study demonstrated the effectiveness of a combined treatment of doxorubicin and natural killer-92 cells against breast cancer, and found that the sensitization of doxorubicin in breast cancer is related to the upregulation of Fas receptor.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2022)

Article Cell Biology

cFLIP downregulation is an early event required for endoplasmic reticulum stress-induced apoptosis in tumor cells

Rocio Mora-Molina et al.

Summary: Protein misfolding or unfolding and the resulting endoplasmic reticulum stress commonly occur in highly proliferative tumors. The role of caspase-8 inhibitor cFLIP in regulating the balance between apoptosis and survival in colon cancer cells undergoing ER stress has been investigated. Maintaining high cFLIP levels during ER stress can inhibit caspase-8 activation and apoptosis, while cFLIP knockdown accelerates caspase-8 activation and apoptosis during ER stress. The resistance of multicellular tumor spheroids to ER stress-induced apoptosis correlates with sustained cFLIP(L) expression.

CELL DEATH & DISEASE (2022)

Article Multidisciplinary Sciences

Combination gemcitabine and PD-L1xCD3 bispecific T cell engager (BiTE) enhances T lymphocyte cytotoxicity against cholangiocarcinoma cells

Methi Wathikthinnakon et al.

Summary: This study proposes a novel approach for treating cholangiocarcinoma by combining gemcitabine and PD-L1xCD3 BiTE, which enhances the cytotoxicity of T lymphocytes against CCA cells.

SCIENTIFIC REPORTS (2022)

Review Hematology

NK Cell Adoptive Immunotherapy of Cancer: Evaluating Recognition Strategies and Overcoming Limitations

Carlos E. Sanchez et al.

Summary: NK cells, as primary effector cells of the innate immune system, use various strategies to recognize and target tumor cells, which have been successfully applied in adoptive NK cell immunotherapies. However, tumor-induced immune escape and suppression may limit the efficacy of these therapies, which can be overcome by conferring NK cells with new functions and surviving the immune-suppressive tumor microenvironment. Additionally, future iterations of NK cell therapies may benefit from combination therapies with other immunotherapeutic agents.

TRANSPLANTATION AND CELLULAR THERAPY (2021)

Review Oncology

NK cell-based cancer immunotherapy: from basic biology to clinical development

Sizhe Liu et al.

Summary: NK cells, as a specialized immune effector cell type, play a critical role in immune activation against abnormal cells. Unlike T cell activation, NK cell activation is governed by interactions between NK receptors and target cells, leading to significant attention in cancer immunotherapy. Many efforts are focused on developing and engineering NK cell-based cancer immunotherapy.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

Article Biochemistry & Molecular Biology

Cordycepin Sensitizes Cholangiocarcinoma Cells to Be Killed by Natural Killer-92 (NK-92) Cells

Suthida Panwong et al.

Summary: Immunotherapy utilizing immune functions is a promising strategy for cancer treatment, and the bioactive compound cordycepin has been shown to enhance the susceptibility of cancer cells to NK cell cytotoxicity, possibly through the TRAIL signaling pathway. This study provides evidence that cordycepin can sensitize cancer cells to NK cell cytotoxicity, supporting its potential as an alternative immunomodulating agent.

MOLECULES (2021)

Article Biotechnology & Applied Microbiology

Strategies to sensitize cancer cells to immunotherapy

Andrew George et al.

Summary: Immunotherapy has shown promise in treating various cancers, but does not work effectively in all cases. Strategies to sensitize tumors are being explored to overcome resistance to immunotherapy and prevent hyperprogression, ultimately aiming to improve treatment effectiveness.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2021)

Review Surgery

Immunotherapy in cholangiocarcinoma: From concept to clinical trials

Wen-Yan Yao et al.

Summary: Cholangiocarcinoma is a bile tract malignancy with poor prognosis and lacking effective treatments, where immunotherapies like ICIs, CAR T-cells, and tumor vaccines aim to reestablish the tumor microenvironment for better antitumor immunity responses, highlighting the need for reliable predictive biomarkers.

SURGERY IN PRACTICE AND SCIENCE (2021)

Review Pharmacology & Pharmacy

Natural compounds as potential adjuvants to cancer therapy: Preclinical evidence

Shian-Ren Lin et al.

BRITISH JOURNAL OF PHARMACOLOGY (2020)

Review Biochemistry & Molecular Biology

Mechanisms of Apoptosis Resistance to NK Cell-Mediated Cytotoxicity in Cancer

Christian Sordo-Bahamonde et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Gastroenterology & Hepatology

Cholangiocarcinoma 2020: the next horizon in mechanisms and management

Jesus M. Banales et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2020)

Article Oncology

Immunotherapy in Biliary Tract Cancer: Worthy of a Second Look

Angela Dalia Ricci et al.

CANCER CONTROL (2020)

Review Cell Biology

Mechanisms of natural killer cell-mediated cellular cytotoxicity

Isabel Prager et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2019)

Article Immunology

NK cells switch from granzyme B to death receptor-mediated cytotoxicity during serial killing

Isabel Prager et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

Review Cell Biology

The role of tumour microenvironment: a new vision for cholangiocarcinoma

Ziyan Chen et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

Review Pharmacology & Pharmacy

Molecular Mechanisms of Action of Genistein in Cancer: Recent Advances

Hardeep Singh Tuli et al.

FRONTIERS IN PHARMACOLOGY (2019)

Review Gastroenterology & Hepatology

Immunobiology of cholangiocarcinoma

Emilien Loeuillard et al.

JHEP REPORTS (2019)

Review Oncology

Cholangiocarcinoma - evolving concepts and therapeutic strategies

Sumera Rizvi et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

Review Oncology

The Influence of Metabolism on Drug Response in Cancer

Esther A. Zaal et al.

FRONTIERS IN ONCOLOGY (2018)

Article Gastroenterology & Hepatology

Bcl-2 degradation is an additional pro-apoptotic effect of polo-like kinase inhibition in cholangiocarcinoma cells

Svenja Sydor et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2017)

Article Multidisciplinary Sciences

Activation of Fas/FasL pathway and the role of c-FLIP in primary culture of human cholangiocarcinoma cells

Gianluca Carnevale et al.

SCIENTIFIC REPORTS (2017)

Article Cell & Tissue Engineering

Treatment of patients with advanced cancer with the natural killer cell line NK-92

Torsten Tonn et al.

CYTOTHERAPY (2013)

Article Gastroenterology & Hepatology

Dendritic Cell-Based Immunotherapy Targeting Synthesized Peptides for Advanced Biliary Tract Cancer

Masanori Kobayashi et al.

JOURNAL OF GASTROINTESTINAL SURGERY (2013)

Article Chemistry, Medicinal

Induction of Apoptosis in HeLa Cells via Caspase Activation by Resveratrol and Genistein

Sivanesan Dhandayuthapani et al.

JOURNAL OF MEDICINAL FOOD (2013)

Article Oncology

Estrogen is increased in male cholangiocarcinoma patients' serum and stimulates invasion in cholangiocarcinoma cell lines in vitro

Taweewun Hunsawong et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2012)

Article Biochemical Research Methods

NIH Image to ImageJ: 25 years of image analysis

Caroline A. Schneider et al.

NATURE METHODS (2012)

Article Medicine, General & Internal

Cisplatin plus Gemcitabine versus Gemcitabine for Biliary Tract Cancer.

Juan Valle et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Article Immunology

Sensitization of tumor cells to NK cell-mediated killing by proteasome inhibition

William H. D. Hallett et al.

JOURNAL OF IMMUNOLOGY (2008)

Review Pathology

Apoptosis: A review of programmed cell death

Susan Elmore

TOXICOLOGIC PATHOLOGY (2007)

Article Gastroenterology & Hepatology

Establishment and characterization of an opisthorchiasis-associated cholangiocarcinoma cell line (KKU-100)

Banchob Sripa et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2005)

Article Gastroenterology & Hepatology

Drug sensitivity and drug resistance profiles of human intrahepatic cholangiocarcinoma cell lines

Nisana Tepsiri et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2005)

Article Biochemistry & Molecular Biology

c-FLIPL is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis

DW Chang et al.

EMBO JOURNAL (2002)