期刊
FRONTIERS IN CARDIOVASCULAR MEDICINE
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcvm.2022.974294
关键词
coronary computed tomography angiography (CCTA); type 2 diabetes mellitus; coronary heart disease; risk stratification prediction; United Kingdom prospective diabetes study
资金
- Taishan Scholars Program of Shandong Province [TS201712065]
- Academic Promotion Program of Shandong First Medical University [2019QL009]
- Science and Technology Funding from Jinan [2020GXRC018]
- Shandong Medical and Health Science and Technology Development Plan Project [202009040454]
- Taian Science and Technology Development Plan Project [2019NS156]
- Jining Key Research and Development Project [2021YXNS044]
This study retrospectively analyzed data from 141 T2DM patients who underwent CCTA, revealing that patients in the moderate-high risk DM groups had higher scores on various CCTA parameters compared to the control group. The study suggests that CHD can be effectively screened in moderate-high risk asymptomatic T2DM patients using CCTA.
BackgroundThere are few data on the clinical significance of coronary computed tomography angiography (CCTA) in asymptomatic type 2 diabetes mellitus (T2DM) patients. We performed a retrospective study to evaluate coronary heart disease (CHD) screening in asymptomatic patients with T2DM using CCTA and CHD risk stratification prediction. Materials and methodsData from 141 T2DM patients (58 +/- 8 years, 57% males) without known symptoms suggestive of CHD who underwent CCTA were retrospectively analyzed. The patients were classified into three subgroups based on United Kingdom prospective diabetes study (UKPDS) CHD risk stratification prediction. Seventy-four patients without diabetes mellitus and CHD who underwent CCTA successively were chosen as the control group. The segment involvement score (SIS), segment stenosis score (SSS), stenosis coefficient (SC), severe proximal plaque (SPP) positive ratio and CCTA-adapted Leaman score (CT-LeSc) based on CCTA data were evaluated and compared among the groups. ResultsCompared with the patients in the control group, patients in the moderate-high risk DM groups had higher scores on the SIS, SSS, SC, CT-LeSc, and a higher SPP positive ratio (all p-values < 0.001), and no difference was observed between the low-risk group and the control group (p = 0.136, p = 0.088, p = 0.0.067, p = 0.225, p = 1.000, respectively). Compared with patients in the control group, the patients in the moderate-high risk DM groups had increased odds of SIS > 3 [odds ratio (OR) = 6.557, p < 0.001; OR = 4.455, p < 0.001, respectively], SSS > 5 (OR = 5.727, p < 0.001; OR = 5.144, p < 0.001, respectively), CT-LeSc > 8.7 (OR = 3.780, p = 0.001; OR = 2.804, p = 0.007, respectively), and obstructive stenosis (OR = 7.233, p < 0.001; OR = 5.787, p < 0.001, respectively). ConclusionThe moderate-high CHD risk patients had increased odds of obstructive coronary artery stenosis, and the distribution of coronary artery stenosis was more extensive and more severe in that group compared to the patients without diabetes mellitus and CHD. CHD can be effectively screened in moderate-high risk asymptomatic T2DM patients using CCTA.
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