期刊
FRONTIERS IN CARDIOVASCULAR MEDICINE
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcvm.2022.818202
关键词
preterm birth; macrophage; cholesterol; low-density lipoprotein receptor; inflammation
资金
- Hunan Provincial Natural Science Foundation of China [2022JJ40675, 2021JJ40852]
- National Natural Science Foundation of China [82100495]
- Scientific Research Project of Hunan Provincial Health Commission [202203014009]
Maternal hypercholesterolemia during pregnancy is associated with increased risk of preterm birth, potentially due to macrophages uptaking excessive cholesterol leading to disruption of immune tolerance and labor initiation.
Maternal hypercholesterolemia during pregnancy is associated with an increased risk of preterm birth which is defined as <37 weeks of complete gestation. However, the underlying mechanism for the association between hypercholesterolemia and preterm birth is not fully understood. Macrophage, as one of the largest cell types in the placenta, plays a very critical role in mediating inflammation and triggers labor initiation. Here, we hypothesize that macrophages can uptake maternal excessive cholesterol leading to its accumulation, resulting in a breach of the immune tolerance and precipitating labor.
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