Resolution of impaired multisensory processing in autism and the cost of switching sensory modality

Crosse et al. study a cohort of 364 participants with autism spectrum disorders (ASD) and matched controls, and show that deficits in multisensory processing observed in high-functioning children and teenagers with ASD are not evident in adults with the disorder. Using computational modelling they go on to demonstrate that there is a delayed transition of multisensory processing from a default state of competition to one of facilitation in ASD, as well as differences in sensory weighting and the ability to switch between sensory modalities, which sheds light on the interplay among sensory systems that differ in ASD individuals. Children with autism spectrum disorders (ASD) exhibit alterations in multisensory processing, which may contribute to the prevalence of social and communicative deficits in this population. Resolution of multisensory deficits has been observed in teenagers with ASD for complex, social speech stimuli; however, whether this resolution extends to more basic multisensory processing deficits remains unclear. Here, in a cohort of 364 participants we show using simple, non-social audiovisual stimuli that deficits in multisensory processing observed in high-functioning children and teenagers with ASD are not evident in adults with the disorder. Computational modelling indicated that multisensory processing transitions from a default state of competition to one of facilitation, and that this transition is delayed in ASD. Further analysis revealed group differences in how sensory channels are weighted, and how this is impacted by preceding cross-sensory inputs. Our findings indicate that there is a complex and dynamic interplay among the sensory systems that differs considerably in individuals with ASD.

Automated summary

The study reveals that deficits in multisensory processing observed in high-functioning children and teenagers with autism spectrum disorders (ASD) are not evident in adults with the disorder. Computational modelling shows a delayed transition of multisensory processing from competition to facilitation in ASD. The findings highlight the complex and dynamic interplay among sensory systems that differ in individuals with ASD.