Effect of Norelgestromin and Ethinylestradiol in Transdermal Patches on the Clinical Outcomes and Biochemical Parameters of COVID-19 Patients: A Clinical Trial Pilot Study

Article Infectious Diseases

Circulating ACE2 activity predicts mortality and disease severity in hospitalized COVID-19 patients

Miklos Fagyas et al.

Summary: This study investigated the circulating ACE2 activity in COVID-19 patients and found that it correlated with disease severity and predicted mortality, suggesting its potential as a prognostic marker.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2022)

添加到收藏夹

Review Microbiology

Characteristics of SARS-CoV-2 and COVID-19

Ben Hu et al.

Summary: This review summarizes the research progress on SARS-CoV-2 and COVID-19, including virology characteristics, pathogenesis, and recent advances in treatment methods. Furthermore, it discusses in detail the potential wildlife hosts and zoonotic origin of this emerging virus.

NATURE REVIEWS MICROBIOLOGY (2021)

添加到收藏夹

Article Medicine, General & Internal

Sex and age differences in COVID-19 mortality in Europe

Linda Juel Ahrenfeldt et al.

Summary: The study found that men had a higher relative risk of dying from COVID-19 compared to women in almost all age groups across ten European regions, but this sex difference decreased with age, with the smallest difference observed in the 80+ age group. Despite variations in data collection and time coverage, the overall pattern of sex differences in COVID-19 mortality in Europe was similar.

WIENER KLINISCHE WOCHENSCHRIFT (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Structural and Functional Analysis of Female Sex Hormones against SARS-CoV-2 Cell Entry

Jorge Alberto Aguilar-Pineda et al.

Summary: Emerging evidence suggests that males are more susceptible to severe infection by the SARS-CoV-2 virus than females, with mechanisms such as sex hormones and ACE2 receptor glycosylation potentially playing a role. Estrogens can disrupt interactions between ACE2 and SARS-CoV-2, reducing viral entry into cells. This sheds light on a potential mechanism by which female sex hormones may protect against severe infection and influence future COVID-19 therapies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Critical Care Medicine

Progesterone in Addition to Standard of Care vs Standard of Care Alone in the Treatment of Men Hospitalized With Moderate to Severe COVID-19 A Randomized, Controlled Pilot Trial

Sara Ghandehari et al.

Summary: By administering subcutaneous progesterone to hypoxemic men hospitalized with moderate to severe COVID-19, it was found that progesterone at a dose of 100 mg, twice daily in addition to standard of care, can safely improve clinical outcomes and reduce the number of days on supplemental oxygen and length of hospital stay.

CHEST (2021)

添加到收藏夹

Article Medicine, General & Internal

Acute estradiol and progesterone therapy in hospitalised adults to reduce COVID-19 severity: a randomised control trial

Dragana Lovre et al.

Summary: This study aims to evaluate the efficacy of short-term E2 and P4 therapy in mitigating disease severity in hospitalized COVID-19 patients. The randomized, double-blind, placebo-controlled trial will assess patient improvement on the WHO scale over 28 days as the primary outcome.

BMJ OPEN (2021)

添加到收藏夹

Review Immunology

The Impact of ACE2 Polymorphisms on COVID-19 Disease: Susceptibility, Severity, and Therapy

Fei Chen et al.

Summary: COVID-19, caused by SARS-CoV-2, is significantly influenced by ACE2 variants and epigenetic factors. Understanding these factors can help explain individual differences in disease susceptibility and outcomes, as well as aid in developing effective solutions and managing future outbreaks of SARS-CoV-2.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

添加到收藏夹

Review Microbiology

SARS-CoV-2 variants, spike mutations and immune escape

William T. Harvey et al.

Summary: The evolution of SARS-CoV-2 has been characterized by the emergence of mutations and variants that impact virus characteristics. Manufacturers are preparing for possible updates to vaccines in response to changes in the virus population, and it is crucial to monitor genetic and antigenic changes alongside experiments to understand the impacts of mutations.

NATURE REVIEWS MICROBIOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Estrogen and COVID-19 symptoms: Associations in women from the COVID Symptom Study

Ricardo Costeira et al.

Summary: The study found that menopausal women had higher rates of predicted COVID-19, while users of combined oral contraceptive pills had lower rates. Hormone replacement therapy usage did not consistently show associations with COVID-19. However, caution should be taken when interpreting the results due to certain limitations in the data collection.

PLOS ONE (2021)

添加到收藏夹

Review Immunology

Immunity, Sex Hormones, and Environmental Factors as Determinants of COVID-19 Disparity in Women

Suriya Rehman et al.

Summary: This study discusses the significant impact of gender on morbidity and mortality of COVID-19, with factors such as innate immune response, estrogen, and microbiota potentially contributing to gender differences. It also highlights certain factors that give women greater resistance to SARS-CoV-2 infection and disease progression.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Obstetrics & Gynecology

Role of short-term estradiol supplementation in symptomatic postmenopausal COVID-19 females: A randomized controlled trial

Shikha Seth et al.

Summary: Oral estradiol can be an effective option for managing nonsevere COVID-19 infection in postmenopausal females.

JOURNAL OF MID-LIFE HEALTH (2021)

添加到收藏夹

Article Physiology

17β-estradiol reduces SARS-CoV-2 infection in vitro

Robertha Mariana Rodrigues Lemes et al.

Summary: COVID-19 originated from Wuhan, China, and has unprecedentedly affected the public health system, society, and economy. Estrogen has been shown to potentially protect cells against SARS-CoV-2 infection by reducing viral load and decreasing TMPRSS2 levels, offering new possibilities for further research on 17β-estradiol in human cell lines infected by SARS-CoV-2.

PHYSIOLOGICAL REPORTS (2021)

添加到收藏夹

Article Medicine, General & Internal

The prognostic significance of erythrocyte sedimentation rate in COVID-19

Tezcan Kaya et al.

Summary: The study found that erythrocyte sedimentation rate was an independent prognostic factor for severity and mortality in patients with COVID-19, with higher levels associated with more severe disease and increased risk of death.

REVISTA DA ASSOCIACAO MEDICA BRASILEIRA (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

The endosomal lipid bis(monoacylglycero) phosphate as a potential key player in the mechanism of action of chloroquine against SARS-COV-2 and other enveloped viruses hijacking the endocytic pathway

Frederic Carriere et al.

BIOCHIMIE (2020)

添加到收藏夹

Review Virology

Predictors of mortality in hospitalized COVID-19 patients: A systematic review and meta-analysis

Wenjie Tian et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Low-dose 17α-ethinyl estradiol (EE) exposure exacerbates lupus renal disease and modulates immune responses to TLR7/9 agonists in genetically autoimmune-prone mice

Michael R. Edwards et al.

SCIENTIFIC REPORTS (2020)

添加到收藏夹

Review Endocrinology & Metabolism

Impact of sex and gender on COVID-19 outcomes in Europe

Catherine Gebhard et al.

BIOLOGY OF SEX DIFFERENCES (2020)

添加到收藏夹

Article Medicine, General & Internal

Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients

Jin Liu et al.

EBIOMEDICINE (2020)

添加到收藏夹

Article Public, Environmental & Occupational Health

Gender Differences in Patients With COVID-19: Focus on Severity and Mortality

Jian-Min Jin et al.

FRONTIERS IN PUBLIC HEALTH (2020)

添加到收藏夹

Review Endocrinology & Metabolism

Estradiol, Progesterone, Immunomodulation, and COVID-19 Outcomes

Franck Mauvais-Jarvis et al.

ENDOCRINOLOGY (2020)

添加到收藏夹

Article Pharmacology & Pharmacy

Cellular and Molecular Pathways of COVID-19 and Potential Points of Therapeutic Intervention

John P. Hussman

FRONTIERS IN PHARMACOLOGY (2020)

添加到收藏夹

Article Infectious Diseases

Mild versus severe COVID-19: Laboratory markers

Thirumalaisamy P. Velavan et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2020)

添加到收藏夹

Review Medicine, General & Internal

COVID-19 and Sex Differences: Mechanisms and Biomarkers

Tu Haitao et al.

MAYO CLINIC PROCEEDINGS (2020)

添加到收藏夹

Article Endocrinology & Metabolism

Severe obesity, increasing age and male sex are independently associated with worse in -hospital outcomes, and higher in -hospital mortality, in a cohort of patients with COVID-19 in the Bronx, New York

Leonidas Palaiodimos et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2020)

添加到收藏夹

Article Microbiology

Biological sex impacts COVID-19 outcomes

Sabra L. Klein et al.

PLOS PATHOGENS (2020)

添加到收藏夹

Review Medical Laboratory Technology

Ferritin in the coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis

Linlin Cheng et al.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2020)

添加到收藏夹

Article Medicine, General & Internal

Evidence for treatment with estradiol for women with SARS-CoV-2 infection

Ute Seeland et al.

BMC MEDICINE (2020)

添加到收藏夹

Article Public, Environmental & Occupational Health

COVID-19 mortality risk for older men and women

N. David Yanez et al.

BMC PUBLIC HEALTH (2020)

添加到收藏夹

Article Cell & Tissue Engineering

Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men

Ryan M. Samuel et al.

CELL STEM CELL (2020)

添加到收藏夹

Article Immunology

Considering how biological sex impacts immune responses and COVID-19 outcomes

Eileen P. Scully et al.

NATURE REVIEWS IMMUNOLOGY (2020)

添加到收藏夹

Article Endocrinology & Metabolism

17β-Estradiol and 17α-Ethinyl Estradiol Exhibit Immunologic and Epigenetic Regulatory Effects in NZB/WF1 Female Mice

Rujuan Dai et al.

ENDOCRINOLOGY (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Women live longer than men even during severe famines and epidemics

Virginia Zarulli et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

添加到收藏夹

Article Endocrinology & Metabolism

Estriol Reduces Pulmonary Immune Cell Recruitment and Inflammation to Protect Female Mice From Severe Influenza

Meghan S. Vermillion et al.

ENDOCRINOLOGY (2018)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Role of the ACE2/Angiotensin 1-7 Axis of the Renin-Angiotensin System in Heart Failure

Vaibhav B. Patel et al.

CIRCULATION RESEARCH (2016)

添加到收藏夹

Review Immunology

Sex differences in immune responses

Sabra L. Klein et al.

NATURE REVIEWS IMMUNOLOGY (2016)

添加到收藏夹

Review Pharmacology & Pharmacy

Transdermal contraception methods: today's patches and new options on the horizon

Anita L. Nelson

EXPERT OPINION ON PHARMACOTHERAPY (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Estrogen Mediates Innate and Adaptive Immune Alterations to Influenza Infection in Pregnant Mice

Michael A. Pazos et al.

PLOS ONE (2012)

添加到收藏夹

Effect of Norelgestromin and Ethinylestradiol in Transdermal Patches on the Clinical Outcomes and Biochemical Parameters of COVID-19 Patients: A Clinical Trial Pilot Study

相关参考文献

导出引文

分享论文