期刊
PHARMACEUTICALS
卷 15, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/ph15070905
关键词
Blechnum; pharmacology; phytochemistry; traditional uses
资金
- National Natural Science Foundation of China [31961143026, 31970211]
- National Science & Technology Fundamental Resources Investigation Program of China [2019FY101800]
- International Partnership Program of the Chinese Academy of Sciences [151853KYSB20190027]
- Sino-Africa Joint Research Center, CAS [SAJC202101]
Blechnum species have been traditionally used in folk medicines to treat various ailments. They contain a wide range of chemical compounds, including phenolic compounds, sterols, and fatty acids. These plants exhibit exceptional biological properties such as antioxidant, antimicrobial, anti-inflammatory, anticancer, insecticidal, antitrematocidal, and wound healing activities. However, understanding their scientific significance based on available data remains challenging.
Blechnum L. is a genus belonging to the Blechnaceae family with 236 accepted species that grow in intertropical, subtropical, and southern temperate regions. Several species of the genus have long been used in folk medicines to treat a broad spectrum of ailments, including typhoid, urinary infections, influenza, wounds, pulmonary complaints, blisters, boils, and antihelmintic-related complications. So far, about 91 chemical compounds have been isolated from different parts of 20 Blechnum species. Among these metabolites, phenolic compounds, sterols, and fatty acids are the main constituents. Modern pharmacological investigations revealed several isolated compounds and extracts to exhibit exceptional biological properties including the antioxidant, antimicrobial, anti-inflammatory, anticancer, insecticidal, antitrematocidal and wound healing. In various tests, both quercetin-7',3',4'-trimethoxy and phytol metabolites showed potential antioxidant and antitrematocidal properties, while ponasterone exhibited insecticidal activity. Despite having a broad range of traditional medicinal benefits and biological properties, understanding the scientific connotations based on the available data is still challenging. This article presents a comprehensive review of the traditional uses, phytochemical compounds, and pharmacological aspects of the Blechnum species.
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