期刊
PHARMACEUTICALS
卷 15, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/ph15080967
关键词
Chrysopogon zizanioides; beta-eudesmol; khusimol; Leishmania amazonensis; periodontopathogens; Trypanosoma cruzi
资金
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2007/54241-8]
This study investigated the chemical composition and potential antibacterial, antiparasitic, and cytotoxic effects of the Brazilian Chrysopogon zizanioides root essential oil (CZ-EO). The results showed that CZ-EO has strong antimicrobial activity against certain bacteria and parasites, while exhibiting low cytotoxicity to host cells. These findings indicate the promising potential of CZ-EO for developing new antimicrobial, antileishmanial, and antitrypanosomal drugs.
This study aimed to investigate the chemical composition as well as the antibacterial, antiparasitic, and cytotoxic potentialities of the Brazilian Chrysopogon zizanioides root essential oil (CZ-EO) In addition, CZ-EO cytotoxicity to LLCMK2 adherent epithelial cells was assessed. The major compounds identified in CZ-EO were khusimol (30.0 +/- 0.3%), beta-eudesmol (10.8 +/- 0.3%), alpha-muurolene (6.0 +/- 0.1%), and patchouli alcohol (5.6 +/- 0.2%). CZ-EO displayed optimal antibacterial activity against Prevotella nigrescens, Fusobacterium nucleatum, Prevotella melaninogenica, and Aggregatibacter actinomycetemcomitans, with Minimum Inhibitory Concentration (MIC) values between 22 and 62.5 mu g/mL and Minimum Bactericidal Concentration (MBC) values between 22 and 400 mu g/mL. CZ-EO was highly active against the L. amazonensis promastigote and amastigote forms (IC50 = 7.20 and 16.21 mu g/mL, respectively) and the T. cruzi trypomastigote form (IC50 = 11.2 mu g/mL). Moreover, CZ-EO showed moderate cytotoxicity to LLCMK2 cells, with CC50 = 565.4 mu g/mL. These results revealed an interesting in vitro selectivity of CZ-EO toward the L. amazonensis promastigote and amastigote forms (Selectivity Index, SI = 78.5 and 34.8, respectively) and the T. cruzi trypomastigote form (SI = 50.5) compared to LLCMK2 cells. These results showed the promising potential of CZ-EO for developing new antimicrobial, antileishmanial, and antitrypanosomal drugs.
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