期刊
ISCIENCE
卷 25, 期 8, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.isci.2022.104745
关键词
-
资金
- Carol Moss Foundation
- [GEO-CM04S1]
Individuals vaccinated with COH04S1 or mRNA vaccine BNT162b2 maintain robust cross-reactive cellular immunity for six or more months post-vaccination, providing long-term protection against both ancestral and variant strains of SARS-CoV-2.
Cell-mediated immunity may contribute to providing protection against SARS-CoV-2 and its variants of concern (VOC). We developed COH04S1, a synthetic multiantigen modified vaccinia Ankara (MVA)-based COVID-19 vaccine that stimulated potent spike (S) and nucleocapsid (N) antigen-specific humoral and cellular immunity in a phase 1 clinical trial in healthy adults. Here, we show that individuals vaccinated with COH04S1 or mRNA vaccine BNT162b2 maintain robust crossreactive cellular immunity for six or more months post-vaccination. Although neutralizing antibodies induced in COH04S1- and BNT162b2-vaccinees showed reduced activity against Delta and Omicron varLnts compared to ancestral SARS-CoV-2, S-specific T cells elicited in both COK04S1- and BNT162b2-vaccinees and N-specific T cells elicited in COH0451-vaccinees demonstrated potent and equivalent cross-reactivity against ancestral SARS-CoV-2 and the major VOC. These results suggest that vaccine-induced T cells to S and N antigens may constitute a critical second line of defense to provide long-term protection against SARS-CoV-2 VOC.
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