4.7 Review

The Journey of Human Transthyretin: Synthesis, Structure Stability, and Catabolism

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cardiac & Cardiovascular Systems

Amyloid seeding as a disease mechanism and treatment target in transthyretin cardiac amyloidosis

Paolo Morfino et al.

Summary: Transthyretin is a transport protein that plays a role in ATTR amyloidosis. Understanding the structure and formation of ATTR seeds is important for the diagnosis and treatment of the disease.

HEART FAILURE REVIEWS (2022)

Article Cell Biology

ATF6 Activation Reduces Amyloidogenic Transthyretin Secretion through Increased Interactions with Endoplasmic Reticulum Proteostasis Factors

Jaleh S. Mesgarzadeh et al.

Summary: This study identified ER proteostasis factors involved in ATF6-dependent reductions in destabilized TTR secretion through a mass-spectrometry-based interactomics approach. Activation of ATF6 reduces the secretion and subsequent aggregation of amyloidogenic TTR through increased interactions with ATF6-regulated ER proteostasis factors including BiP and PDIA4. PDIA4 retains destabilized TTR in the ER through a redox-independent mechanism. These findings provide a mechanistic basis for the therapeutic targeting of ATF6 activation to improve treatments for TTR-related amyloid diseases.
Article Biochemistry & Molecular Biology

Thermodynamic Stability and Aggregation Kinetics of EF Helix and EF Loop Variants of Transthyretin

James A. Ferguson et al.

Summary: This study used F-19 nuclear magnetic resonance to investigate the impact of pathogenic mutations on the aggregation kinetics and stability of both the TTR tetramer and monomer. The findings revealed that certain mutations destabilize TTR and promote aggregation, while others disrupt a Schellman helix C-capping motif and increase the monomer's aggregation rate. These insights shed light on how subtle mutations affecting tetramer or monomer stability can drive TTR into the dissociation-aggregation pathway.

BIOCHEMISTRY (2021)

Review Pharmacology & Pharmacy

The Structural Understanding of Transthyretin Misfolding and the Inspired Drug Approaches for the Treatment of Heart Failure Associated With Transthyretin Amyloidosis

Shan He et al.

Summary: Substantial controversies exist in the exploration of the molecular mechanism of heart failure, with recent research suggesting that cardiac transthyretin (TTR) amyloidosis is a major underdiagnosed cause. Investigating and modulating TTR misfolding and amyloidal aggregation can provide new insights into the molecular mechanisms of heart failure and offer novel treatment possibilities.

FRONTIERS IN PHARMACOLOGY (2021)

Article Multidisciplinary Sciences

Role of mutations and post-translational modifications in systemic AL amyloidosis studied by cryo-EM

Lynn Radamaker et al.

Summary: The authors presented the cryo-EM structure of an AL amyloid fibril with mutational changes, disulfide bond, and glycosylation, indicating their roles in determining the protein fold and protecting the fibril core from degradation. Systemic AL amyloidosis is caused by misfolding of immunoglobulin light chains (LCs), with the influence of LCs' post-translational modifications on amyloid formation still not well understood.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Structural basis for transthyretin amyloid formation in vitreous body of the eye

Irina Iakovleva et al.

Summary: The study used cryo-EM to analyze the structure of vitreous body ATTR fibrils from an ATTR patient's eye, revealing differences from previously studied heart fibrils with the same mutation, indicating variations in ATTR protein structure and assembly in type A fibrils among patients with the same mutation. By analyzing amino acid interfaces, a mechanism for the structural conversion of TTR into fibrillar form was proposed.

NATURE COMMUNICATIONS (2021)

Article Cardiac & Cardiovascular Systems

Diagnosis and treatment of cardiac amyloidosis. A position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases

Pablo Garcia-Pavia et al.

Summary: Cardiac amyloidosis is a serious and progressive infiltrative disease caused by the deposition of amyloid fibrils in the heart. With advances in imaging techniques and non-invasive diagnosis, it is now recognized as more common than traditionally believed. The Working Group on Myocardial and Pericardial Disease has proposed definitions, diagnostic algorithms, and treatment strategies to help bridge the gap between the latest research and clinical practice in managing cardiac amyloidosis.

EUROPEAN JOURNAL OF HEART FAILURE (2021)

Review Biochemistry & Molecular Biology

Transthyretin Misfolding, A Fatal Structural Pathogenesis Mechanism

Jin-Beom Si et al.

Summary: TTR is a crucial transporter of thyroid hormone and retinol binding protein in human plasma and cerebrospinal fluid, yet it is also known for its amyloidogenic nature leading to various amyloidoses. Research has shown that decreased stability of TTR's native tetrameric conformation is the main cause of these diseases, and recent multidisciplinary investigations have shed light on the mechanistic details of TTR amyloidogenic transformation. Special emphasis has been placed on identifying novel structural features in amyloidogenic species of TTR and discussing the proteolysis-induced fragmentation mechanism that promotes TTR amyloidosis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Oncology

Effect of Tafamidis on Serum Transthyretin Levels in Non-Trial Patients With Transthyretin Amyloid Cardiomyopathy

Rodney H. Falk et al.

Summary: The study showed that tafamidis therapy significantly increases serum TTR levels in patients with ATTR cardiomyopathy, indicating a stabilizing effect. Changes in TTR levels post-therapy may serve as a surrogate marker for stabilization and a more accurate measure of drug efficacy compared to in vitro tests.

JACC: CARDIOONCOLOGY (2021)

Article Multidisciplinary Sciences

A human antibody selective for transthyretin amyloid removes cardiac amyloid through phagocytic immune cells

Aubin Michalon et al.

Summary: Through analyzing memory B cell repertoires of healthy elderly, researchers developed a selective human antibody that removes cardiac amyloid by recruiting phagocytic immune cells.

NATURE COMMUNICATIONS (2021)

Review Cell Biology

Transthyretin: From Structural Stability to Osteoarticular and Cardiovascular Diseases

Elzbieta Wieczorek et al.

Summary: TTR plays multiple roles in the body, serving as an indicator of nutrition status and a neuroprotective factor. The structural stability of TTR is closely linked to oxidative stress and Ca2+, which may contribute to the development of TTR-related diseases.
Review Hematology

The Pathology of Amyloidosis in Classification: A Review

Maria M. Picken

ACTA HAEMATOLOGICA (2020)

Article Multidisciplinary Sciences

Origin and function of the yolk sac in primate embryogenesis

Connor Ross et al.

NATURE COMMUNICATIONS (2020)

Review Biochemistry & Molecular Biology

Natural compounds as inhibitors of transthyretin amyloidosis and neuroprotective agents: analysis of structural data for future drug design

Lidia Ciccone et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2020)

Review Biochemistry & Molecular Biology

Uncovering the Neuroprotective Mechanisms of Curcumin on Transthyretin Amyloidosis

Nelson Ferreira et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Cardiac & Cardiovascular Systems

Transthyretin Stabilization by AG10 in Symptomatic Transthyretin Amyloid Cardiomyopathy

Daniel P. Judge et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2019)

Article Multidisciplinary Sciences

A molecular mechanism for transthyretin amyloidogenesis

Ai Woon Yee et al.

NATURE COMMUNICATIONS (2019)

Review Biochemistry & Molecular Biology

Assessment of patients with hereditary transthyretin amyloidosis - understanding the impact of management and disease progression

Isabel Conceicao et al.

AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS (2019)

Review Biochemistry & Molecular Biology

Diagnostic and Treatment Approaches Involving Transthyretin in Amyloidogenic Diseases

Gil Yong Park et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Biochemistry & Molecular Biology

A cell-based high-throughput screening method to directly examine transthyretin amyloid fibril formation at neutral pH

Mitsuharu Ueda et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

Article Multidisciplinary Sciences

Transthyretin Aggregation Pathway toward the Formation of Distinct Cytotoxic Oligomers

Anvesh K. R. Dasari et al.

SCIENTIFIC REPORTS (2019)

Article Biochemistry & Molecular Biology

NMR Measurements Reveal the Structural Basis of Transthyretin Destabilization by Pathogenic Mutations

Benjamin Leach et al.

BIOCHEMISTRY (2018)

Article Multidisciplinary Sciences

Evaluating the effect of mutations and ligand binding on transthyretin homotetramer dynamics

Tadeo. E. Saldaono et al.

PLOS ONE (2017)

Article Genetics & Heredity

Amyloid β Modification: A Key to the Sporadic Alzheimer's Disease?

Evgeny P. Barykin et al.

FRONTIERS IN GENETICS (2017)

Review Nutrition & Dietetics

Is transthyretin a good marker of nutritional status?

S. Delliere et al.

CLINICAL NUTRITION (2017)

Article Biochemistry & Molecular Biology

Novel Antibody for the Treatment of Transthyretin Amyloidosis

Akihiko Hosoi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Article Pharmacology & Pharmacy

Structural stabilization of transthyretin by a new compound, 6-benzoyl-2-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione

Takeshi Yokoyama et al.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2015)

Review Nutrition & Dietetics

Plasma Transthyretin as a Biomarker of Lean Body Mass and Catabolic States

Yves Ingenbleek et al.

ADVANCES IN NUTRITION (2015)

Article Biochemistry & Molecular Biology

Cooperative Stabilization of Transthyretin by Clusterin and Diflunisal

Michael J. Greene et al.

BIOCHEMISTRY (2015)

Article Cell Biology

Post-translational modifications of transthyretin affect the triiodonine-binding potential

Andrea Henze et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2015)

Article Genetics & Heredity

Online Registry for Mutations in Hereditary Amyloidosis Including Nomenclature Recommendations

Dorota M. Rowczenio et al.

HUMAN MUTATION (2014)

Review Biochemistry & Molecular Biology

Extracellular Chaperones and Proteostasis

Amy R. Wyatt et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 82 (2013)

Article Biochemistry & Molecular Biology

Age-Related Oxidative Modifications of Transthyretin Modulate Its Amyloidogenicity

Lei Zhao et al.

BIOCHEMISTRY (2013)

Article Biochemistry & Molecular Biology

Heparin Promotes the Rapid Fibrillization of a Peptide with Low Intrinsic Amyloidogenicity

Jidlian Madine et al.

BIOCHEMISTRY (2013)

Article Medicine, Research & Experimental

Fibroblasts endocytose and degrade transthyretin aggregates in transthyretin-related amyloidosis

Yohei Misumi et al.

LABORATORY INVESTIGATION (2013)

Article Developmental Biology

Transthyretin and the human placenta

K. A. Landers et al.

PLACENTA (2013)

Article Cell Biology

Protein Folding in the Endoplasmic Reticulum

Ineke Braakman et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)

Article Biochemistry & Molecular Biology

Novel function of transthyretin in pancreatic alpha cells

Yu Su et al.

FEBS LETTERS (2012)

Article Biochemistry & Molecular Biology

Sulfated Glycosaminoglycans Accelerate Transthyretin Amyloidogenesis by Quaternary Structural Conversion

Steve Bourgault et al.

BIOCHEMISTRY (2011)

Article Developmental Biology

Ontogenic changes in placental transthyretin

J. Patel et al.

PLACENTA (2011)

Review Endocrinology & Metabolism

Delivery of maternal thyroid hormones to the fetus

Jatin Patel et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2011)

Article Biochemistry & Molecular Biology

Retinol and Retinol-Binding Protein Stabilize Transthyretin via Formation of Retinol Transport Complex

Suk-Joon Hyung et al.

ACS CHEMICAL BIOLOGY (2010)

Article Biochemistry & Molecular Biology

Role of the Glutamic Acid 54 Residue in Transthyretin Stability and Thyroxine Binding

Masanori Miyata et al.

BIOCHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Binding and stabilization of transthyretin by curcumin

Raghu Pullakhandam et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2009)

Article Endocrinology & Metabolism

Hormone delivery systems to the brain - transthyretin

G. Schreiber et al.

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES (2009)

Review Biochemistry & Molecular Biology

Evolutionary changes to transthyretin: structure-function relationships

P. Prapunpoj et al.

FEBS JOURNAL (2009)

Article Biochemistry & Molecular Biology

The Endoplasmic Reticulum-associated Degradation of Transthyretin Variants Is Negatively Regulated by BiP in Mammalian Cells

Seiko Susuki et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Serum transthyretin levels in senile systemic amyloidosis: effects of age, gender and ethnicity

Joel Buxbaum et al.

AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS (2008)

Article Endocrinology & Metabolism

Transthyretin and Amyloid in the Islets of Langerhans in Type-2 Diabetes

Gunilla T. Westermark et al.

EXPERIMENTAL DIABETES RESEARCH (2008)

Article Biochemistry & Molecular Biology

Structural basis for the protective role of sulfite against transthyretin amyloid formation

Luis Gales et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2007)

Article Biochemistry & Molecular Biology

Orally administered diflunisal stabilizes transthyretin against dissociation required for amyloidogenesis

Yoshiki Sekijima et al.

AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS (2006)

Article Biochemistry & Molecular Biology

Biochemical characterization of vitreous and cardiac amyloid in Ile84Ser transthyretin amyloidosis

Yuris J. Liepnieks et al.

AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS (2006)

Article Biochemistry & Molecular Biology

Clusterin in cerebrospinal fluid:: Analysis of carbohydrates and quantification of native and glycosylated forms

A. -M. Nilselid et al.

NEUROCHEMISTRY INTERNATIONAL (2006)

Article Biochemistry & Molecular Biology

Retention of misfolded mutant transthyretin by the chaperone BiP/GRP78 mitigates amyloidogenesis

K Sörgjerd et al.

JOURNAL OF MOLECULAR BIOLOGY (2006)

Article Endocrinology & Metabolism

Synthesis of thyroid hormone binding proteins transthyretin and albumin by human trophoblast

B McKinnon et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2005)

Article Multidisciplinary Sciences

Transthyretin constitutes a functional component in pancreatic β-cell stimulus-secretion coupling

E Refai et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

The biological and chemical basis for tissue-selective amyloid disease

Y Sekijima et al.

Article Biochemistry & Molecular Biology

Adult neural stem cell cycling in vivo requires thyroid hormone and its alpha receptor

GF Lemkine et al.

FASEB JOURNAL (2005)

Article Pathology

Cysteine 10 is a key residue in amyloidogenesis of human transthyretin Va130Met

Y Takaoka et al.

AMERICAN JOURNAL OF PATHOLOGY (2004)

Article Biochemistry & Molecular Biology

Transthyretin aggregation under partially denaturing conditions is a downhill polymerization

AR Hurshman et al.

BIOCHEMISTRY (2004)

Review Multidisciplinary Sciences

Therapeutic approaches to protein-misfolding diseases

FE Cohen et al.

NATURE (2003)

Article Multidisciplinary Sciences

Quality control in the endoplasmic reticulum protein factory

R Sitia et al.

NATURE (2003)

Article Biochemistry & Molecular Biology

Cys10 mixed disulfides make transthyretin more amyloidogenic under mildly acidic conditions

QH Zhang et al.

BIOCHEMISTRY (2003)

Review Cell Biology

ER-associated degradation in protein quality control and cellular regulation

RY Hampton

CURRENT OPINION IN CELL BIOLOGY (2002)

Article Medical Laboratory Technology

Transthyretin from discovery to now

J Robbins

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2002)

Article Medical Laboratory Technology

Transthyretin as a thyroid hormone carrier: Function revisited

JA Palha

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2002)

Review Biochemistry & Molecular Biology

Transthyretin: a review from a structural perspective

JA Hamilton et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2001)

Article Biochemistry & Molecular Biology

Tetramer dissociation and monomer partial unfolding precedes protofibril formation in amyloidogenic transthyretin variants

A Quintas et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Article Biochemistry & Molecular Biology

Internalization of transthyretin - Evidence of a novel yet unidentified receptor-associated protein (RAP)-sensitive receptor

MM Sousa et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Article Biochemistry & Molecular Biology

Evidence for the role of megalin in renal uptake of transthyretin

MM Sousa et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

Article Biochemistry & Molecular Biology

A comparative analysis of 23 structures of the amyloidogenic protein transthyretin

A Hörnberg et al.

JOURNAL OF MOLECULAR BIOLOGY (2000)

Article Biochemistry & Molecular Biology

Comparative studies of two transthyretin variants with protective effects on familial amyloidotic polyneuropathy: TTR R104H and TTR T119M

MR Almeida et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)

Review Endocrinology & Metabolism

Evolution of the thyroid hormone-binding protein, transthyretin

DM Power et al.

GENERAL AND COMPARATIVE ENDOCRINOLOGY (2000)

Article Toxicology

Distribution of lead and transthyretin in human eyes

JW Eichenbaum et al.

JOURNAL OF TOXICOLOGY-CLINICAL TOXICOLOGY (2000)