4.7 Review

The Potential Application and Promising Role of Targeted Therapy in Pulmonary Arterial Hypertension

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cardiac & Cardiovascular Systems

Update on Medical Management of Pulmonary Arterial Hypertension

Alexander E. Sherman et al.

CARDIOLOGY CLINICS (2022)

Review Pharmacology & Pharmacy

Current and future treatments of pulmonary arterial hypertension

Natascha Sommer et al.

Summary: Therapeutic options for pulmonary arterial hypertension (PAH) have increased in recent decades, focusing on targeting underlying pathways of aberrant proliferation, migration, and apoptosis. Despite success in preclinical models, the transfer to positive outcomes in clinical trials for human disease is limited.

BRITISH JOURNAL OF PHARMACOLOGY (2021)

Article Cardiac & Cardiovascular Systems

PPARγ-p53-Mediated Vasculoregenerative Program to Reverse Pulmonary Hypertension

Jan K. Hennigs et al.

Summary: Activation of the PPAR gamma-p53 transcription factor complex in pulmonary endothelial cells offers a novel therapeutic strategy to rehabilitate damaged PAECs, regenerate pulmonary microvessels, and reverse disease progression in pulmonary arterial hypertension.

CIRCULATION RESEARCH (2021)

Article Oncology

Plasminogen activator Inhibitor-2 inhibits pulmonary arterial smooth muscle cell proliferation in pulmonary arterial hypertension via PI3K/Akt and ERK signaling

Shuai Zhang et al.

Summary: The level of PAI-2 is decreased in PAH patients and negatively correlated with disease severity. PAI-2 attenuates PAH development by inhibiting PASMC proliferation and the activation of PI3K/Akt and ERK pathways. PAI-2 may serve as a potential biomarker and therapeutic target for PAH.

EXPERIMENTAL CELL RESEARCH (2021)

Review Biochemistry & Molecular Biology

Endothelial Dysfunction in Pulmonary Hypertension: Cause or Consequence?

Kondababu Kurakula et al.

Summary: This review highlights the crucial role of endothelial cell dysfunction in pulmonary arterial hypertension (PAH) and its contribution to the progression of the disease. The activation of various cellular signaling pathways due to endothelial cell dysfunction ultimately leads to pulmonary artery remodeling and occlusion. Understanding the molecular signals orchestrating endothelial cell dysfunction in PAH is essential for exploring therapeutic interventions targeting this process.

BIOMEDICINES (2021)

Review Biochemistry & Molecular Biology

mTOR Signaling in Pulmonary Vascular Disease: Pathogenic Role and Therapeutic Target

Aleksandra Babicheva et al.

Summary: Pulmonary arterial hypertension (PAH) is a progressive and fatal disease with complex pathogenic mechanisms. The mTOR pathway plays a major role in regulating cell proliferation and migration. Despite advancements in understanding PAH over the past two decades, there is still a lack of effective therapeutic options for treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biophysics

TRIM32 inhibits the proliferation and migration of pulmonary artery smooth muscle cells through the inactivation of PI3K/Akt pathway in pulmonary arterial hypertension

Zhi Hu et al.

Summary: TRIM32 plays a crucial role in the development of PAH by regulating proliferation, migration, apoptosis, and dedifferentiation of PASMCs through the PI3K/Akt signaling pathway. It may be a potential target for the treatment of PAH.

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2021)

Article Cell Biology

ERK/Drp1-dependent mitochondrial fission contributes to HMGB1-induced autophagy in pulmonary arterial hypertension

Wei Feng et al.

Summary: This study demonstrates that HMGB1 promotes PASMCs proliferation/migration and pulmonary vascular remodelling by activating the ERK1/2/Drp1/Autophagy/BMPR2/Id1 axis, suggesting that this cascade might be a potential novel target for management of PAH.

CELL PROLIFERATION (2021)

Article Oncology

PDGF mediates pulmonary arterial smooth muscle cell proliferation and migration by regulating NFATc2

Fang-Yun Zhao et al.

Summary: The study found that PDGF enhances the proliferation and migration of PASMCs by regulating NFATc2, suggesting a potential therapeutic target for PAH treatment.

MOLECULAR MEDICINE REPORTS (2021)

Article Critical Care Medicine

Long Noncoding RNA TYKRIL Plays a Role in Pulmonary Hypertension via the p53-mediated Regulation of PDGFRβ

Christoph M. Zehendner et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

Review Respiratory System

Guidelines for the Treatment of Pulmonary Arterial Hypertension

Zoe G. S. Vazquez et al.

Article Multidisciplinary Sciences

Role of smooth muscle cell p53 in pulmonary arterial hypertension

Takayuki Wakasugi et al.

PLOS ONE (2019)

Article Critical Care Medicine

Multicenter Preclinical Validation of BET Inhibition for the Treatment of Pulmonary Arterial Hypertension

Diederik E. Van der Feen et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2019)

Editorial Material Respiratory System

An overview of the 6th World Symposium on Pulmonary Hypertension

Nazzareno Galie et al.

EUROPEAN RESPIRATORY JOURNAL (2019)

Article Respiratory System

Haemodynamic definitions and updated clinical classification of pulmonary hypertension

Gerald Simonneau et al.

EUROPEAN RESPIRATORY JOURNAL (2019)

Article Pharmacology & Pharmacy

HMGB1/TLR4 promotes hypoxic pulmonary hypertension via suppressing BMPR2 signaling

Jin Wang et al.

VASCULAR PHARMACOLOGY (2019)

Review Medicine, Research & Experimental

Bromodomain and extra-terminal motif inhibitors: a review of preclinical and clinical advances in cancer therapy

Ali Alqahtani et al.

FUTURE SCIENCE OA (2019)

Article Critical Care Medicine

Mitochondrial HSP90 Accumulation Promotes Vascular Remodeling in Pulmonary Arterial Hypertension

Olivier Boucherat et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2018)

Review Medicine, General & Internal

Pulmonary arterial hypertension: pathogenesis and clinical management

Thenappan Thenappan et al.

BMJ-BRITISH MEDICAL JOURNAL (2018)

Review Medicine, General & Internal

Pulmonary arterial hypertension: pathogenesis and clinical management

Thenappan Thenappan et al.

BMJ-BRITISH MEDICAL JOURNAL (2018)

Article Cardiac & Cardiovascular Systems

Targeted therapy of pulmonary arterial hypertension: Updated recommendations from the Cologne Consensus Conference 2018

Marius M. Hoeper et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2018)

Review Cardiac & Cardiovascular Systems

The cancer theory of pulmonary arterial hypertension

Olivier Boucherat et al.

PULMONARY CIRCULATION (2017)

Review Cardiac & Cardiovascular Systems

Pulmonary arterial hypertension: Basic knowledge for clinicians

Diana Santos-Ribeiro et al.

ARCHIVES OF CARDIOVASCULAR DISEASES (2016)

Article Physiology

Deficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypertension

Haiyang Tang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2015)

Article Cardiac & Cardiovascular Systems

Bromodomain-Containing Protein 4 The Epigenetic Origin of Pulmonary Arterial Hypertension

Jolyane Meloche et al.

CIRCULATION RESEARCH (2015)

Article Cardiac & Cardiovascular Systems

Efficacy and Safety of Exercise Training in Chronic Pulmonary Hypertension Systematic Review and Meta-Analysis

Ambarish Pandey et al.

CIRCULATION-HEART FAILURE (2015)

Article Chemistry, Medicinal

Evaluation of WO-2014132220, selective PDGFR inhibitors for the treatment of pulmonary arterial hypertension

Peter Norman

EXPERT OPINION ON THERAPEUTIC PATENTS (2015)

Article Cardiac & Cardiovascular Systems

Statement on pregnancy in pulmonary hypertension from the Pulmonary Vascular Research Institute

Anna R. Hemnes et al.

PULMONARY CIRCULATION (2015)

Article Cardiac & Cardiovascular Systems

The Metabolic Theory of Pulmonary Arterial Hypertension

Roxane Paulin et al.

CIRCULATION RESEARCH (2014)

Article Biochemistry & Molecular Biology

Rapamycin Reverses Pulmonary Artery Smooth Muscle Cell Proliferation in Pulmonary Hypertension

Amal Houssaini et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2013)

Review Medicine, Research & Experimental

Glutamine and cancer: cell biology, physiology, and clinical opportunities

Christopher T. Hensley et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Review Respiratory System

Pathogenesis of pulmonary arterial hypertension: lessons from cancer

Christophe Guignabert et al.

EUROPEAN RESPIRATORY REVIEW (2013)

Article Critical Care Medicine

Lung 18F-Fluorodeoxyglucose Positron Emission Tomography for Diagnosis and Monitoring of Pulmonary Arterial Hypertension

Glenn Marsboom et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2012)

Article Respiratory System

Pregnancy outcomes in pulmonary arterial hypertension in the modern management era

Xavier Jais et al.

EUROPEAN RESPIRATORY JOURNAL (2012)

Article Medicine, Research & Experimental

Molecular pathogenesis of pulmonary arterial hypertension

Marlene Rabinovitch

JOURNAL OF CLINICAL INVESTIGATION (2012)

Article Physiology

p53 Gene deficiency promotes hypoxia-induced pulmonary hypertension and vascular remodeling in mice

Shiro Mizuno et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2011)

Article Cardiac & Cardiovascular Systems

Long-term response to calcium-channel blockers in non-idiopathic pulmonary arterial hypertension

David Montani et al.

EUROPEAN HEART JOURNAL (2010)

Article Critical Care Medicine

Antiproliferative effects of phosphodiesterase type 5 inhibition in human pulmonary artery cells

J Wharton et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2005)

Article Cardiac & Cardiovascular Systems

Long-term response to calcium channel blockers in idiopathic pulmonary arterial hypertension

O Sitbon et al.

CIRCULATION (2005)

Review Medicine, General & Internal

Drug therapy: Treatment of pulmonary arterial hypertension

M Humbert et al.

NEW ENGLAND JOURNAL OF MEDICINE (2004)

Article Cardiac & Cardiovascular Systems

Cellular and molecular pathobiology of pulmonary arterial hypertension

M Humbert et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2004)