期刊
BIOMEDICINES
卷 10, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/biomedicines10071657
关键词
multiple myeloma; free light-chain ratio; renal failure; prognosis; free light chains
资金
- Intramural Program of the Department of Medicine, Surgery and Dentistry, University of Salerno, Italy
The study found that the serum free light-chain (FLC) ratio in plasma cell disorder patients is associated with disease burden and renal damage. This finding is important for early identification of renal damage and minimizing the risk of late renal failure.
The serum free light-chain (FLC) ratio is a sensitive tool for the differential diagnosis of plasma cell disorders and is biomarker of multiple myeloma (MM) progression from premalignant conditions. Here, we investigate the potential role of FLC ratio at diagnosis in identifying early renal damage in MM patients and other correlations with clinical, laboratory, and molecular findings. A total of 34 MM patients who had undergone autologous stem cell transplantation were included in this retrospective case series study, and FLC quantification was performed with nephelometric assays. In our study, sFLC ratio was significantly associated with light-chain MM and beta-2 microglobulin levels, likely indicating a high disease burden at diagnosis, especially in patients without heavy chain M-protein at serum electrophoresis. Moreover, the sFLC ratio was inversely correlated with glomerular filtration rate, possibly identifying early renal damage in MM patients. Our preliminary results confirm the importance of early sFLC evaluation, especially in patients with the light-chain MM type and low disease burden, to minimize the risk of late renal failure.
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