4.7 Article

Change in PD-L1 and CD8 Expression after Chemoradiotherapy for Esophageal Squamous Cell Carcinoma

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Oncology

Immunotherapy for Esophageal Cancer: State-of-the Art in 2021

Hugo Teixeira Farinha et al.

Summary: This review discusses the rationale for immunotherapy in different stages of esophageal cancer treatment and provides an overview of ongoing clinical trials and novel targeted agents. Immunotherapy shows promise in the early treatment of esophageal cancer, and new approaches are being developed.

CANCERS (2022)

Article Medicine, General & Internal

Adjuvant Nivolumab in Resected Esophageal or Gastroesophageal Junction Cancer

Ronan J. Kelly et al.

Summary: In patients with resected esophageal or gastroesophageal junction cancer who had received neoadjuvant chemoradiotherapy, adjuvant therapy with nivolumab significantly improved disease-free survival compared to placebo.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Oncology

Comprehensive assessment of PD-L1 expression, tumor mutational burden and oncogenic driver alterations in non-small cell lung cancer patients treated with immune checkpoint inhibitors

Kiyotaka Yoh et al.

Summary: This study investigated the associations among PD-L1 expression, tumor mutational burden (TMB), and oncogenic driver alterations in NSCLC patients treated with ICIs. Patients with high PD-L1 expression and high TMB showed a good response to ICIs, while EGFR or STK11 mutations were associated with lower PD-L1 expression and efficacy of ICIs. Comprehensive assessment of these factors could help predict the clinical outcomes of ICIs in NSCLC patients.

LUNG CANCER (2021)

Review Oncology

Prognostic Function of Programmed Cell Death-Ligand 1 in Esophageal Squamous Cell Carcinoma Patients Without Preoperative Therapy: A Systematic Review and Meta-Analysis

Hongxia Cui et al.

Summary: The study showed that PD-L1 expression was not associated with overall survival and disease-free survival in ESCC patients not receiving preoperative therapy. PD-L1 expression did not significantly correlate with sex, degree of differentiation, TNM stage, etc., but showed higher expression in older patients compared to younger patients.

FRONTIERS IN ONCOLOGY (2021)

Article Oncology

Nivolumab for esophageal squamous cell carcinoma and the predictive role of PD-L1 or CD8 expression in its therapeutic effect

Jiyun Lee et al.

Summary: Nivolumab showed a valuable option as subsequent treatment lines for patients with advanced ESCC, with an objective response rate of 19.3% and a median response duration of 6.5 months. Patients with a combined positive score (CPS) ≥1 demonstrated a significantly longer progression-free survival (PFS).

CANCER IMMUNOLOGY IMMUNOTHERAPY (2021)

Article Oncology

Immunosuppressive Phenotype of Esophagus Tumors Stroma

Olga V. Kovaleva et al.

ANALYTICAL CELLULAR PATHOLOGY (2020)

Review Multidisciplinary Sciences

Cancer immunotherapy using checkpoint blockade

Antoni Ribas et al.

SCIENCE (2018)

Review Medicine, General & Internal

Immunotherapy for esophageal squamous cell carcinoma : a review

Kosaku Mimura et al.

FUKUSHIMA JOURNAL OF MEDICAL SCIENCE (2018)