4.7 Article

Network Proximity-Based Drug Repurposing Strategy for Early and Late Stages of Primary Biliary Cholangitis

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Gastroenterology & Hepatology

Obeticholic acid improves hepatic bile acid excretion in patients with primary biliary cholangitis

Kristoffer Kjaergaard et al.

Summary: The study demonstrated that OCA increased the hepatic transport of conjugated bile acids in PBC patients, reducing the time hepatocytes are exposed to potentially toxic bile acids.

JOURNAL OF HEPATOLOGY (2021)

Editorial Material Critical Care Medicine

Etoposide as Salvage Therapy for Cytokinf Storm Due to Coronavirus Disease 2019

Maulin Patel et al.

Summary: COVID-19 has caused significant morbidity and mortality due to a lack of effective therapies. Treatment strategies targeting the overactive cytokine response are being investigated, with a unique case reporting responsiveness to etoposide, suggesting its potential role as salvage therapy for cytokine storm in COVID-19. This is the first reported case of etoposide use in COVID-19.
Letter Gastroenterology & Hepatology

Chronic fatigue should not be overlooked in primary biliary cholangitis

Endrit Shahini et al.

JOURNAL OF HEPATOLOGY (2021)

Article Multidisciplinary Sciences

p-STAT3 is a PDC-E2 interacting partner in human cholangiocytes and hepatocytes with potential pathobiological implications

Ewa Kilanczyk et al.

Summary: The study revealed an interaction between PDC-E2 and phosphorylated STAT3 under cholestatic conditions, which may play a role in the development of primary biliary cholangitis.

SCIENTIFIC REPORTS (2021)

Article Infectious Diseases

Longitudinal study based on a safety registry for malaria patients treated with artenimol-piperaquine in six European countries

Nicolas Vignier et al.

Summary: The study recruited 294 participants from European countries, showing that artenimol-piperaquine is effective and well-tolerated for malaria treatment in this population. Adverse events and QT prolongation rates were similar to those seen in larger cohorts from endemic regions.

MALARIA JOURNAL (2021)

Article Genetics & Heredity

NCK-associated protein 1 like (nckap1l) minor splice variant regulates intrahepatic biliary network morphogenesis

Kimia Ghaffari et al.

Summary: In this study, a mutation in the nckap1l gene affecting a short splice isoform was identified as causing specific branching morphogenesis defects in the intrahepatic biliary network in zebrafish. The Nckap1l protein was found to be expressed in biliary epithelial cells, and the mutant gene was shown to interact with the Cdk5 pathway in regulating actin dynamics. The study revealed a previously unappreciated link between hematopoietic and biliary cell lineages, highlighting the role of the minor splice isoform of nckap1l in biliary system formation.

PLOS GENETICS (2021)

Article Immunology

Baricitinib and primary biliary cholangitis

Stuart C. Gordon et al.

Summary: The study aimed to evaluate the use of baricitinib in PBC patients who do not respond well to UDCA treatment. Despite early termination due to low enrollment, the results showed a dramatic response to baricitinib treatment in one patient.

JOURNAL OF TRANSLATIONAL AUTOIMMUNITY (2021)

Article Gastroenterology & Hepatology

Long-Term Obeticholic Acid Therapy Improves Histological Endpoints in Patients With Primary Biliary Cholangitis

Christopher L. Bowlus et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2020)

Letter Gastroenterology & Hepatology

Letter to the Editor: Might Denosumab Fit in Primary Biliary Cholangitis Treatment?

Ana Lleo et al.

HEPATOLOGY (2020)

Review Gastroenterology & Hepatology

Current and potential treatments for primary biliary cholangitis

Raj A. Shah et al.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2020)

Review Gastroenterology & Hepatology

Variants in ABCB4 (MDR3) across the spectrum of cholestatic liver diseases in adults

Albert Friedrich Staettermayer et al.

JOURNAL OF HEPATOLOGY (2020)

Review Medicine, Research & Experimental

Molecular networks in Network Medicine: Development and applications

Edwin K. Silverman et al.

WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE (2020)

Article Cell Biology

Designing a Network Proximity-Based Drug Repurposing Strategy for COVID-19

Paola Stolfi et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Editorial Material Immunology

Editorial: Sex Hormones and Gender Differences in Immune Responses

Elena Ortona et al.

FRONTIERS IN IMMUNOLOGY (2019)

Review Cell Biology

What Is Nuclear Factor Kappa B (NF-κB) Doing in and to the Mitochondrion?

Benedict C. Albensi

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2019)

Article Rheumatology

Anakinra in children and adults with Still's disease

Sebastiaan J. Vastert et al.

RHEUMATOLOGY (2019)

Article Gastroenterology & Hepatology

A randomized trial of obeticholic acid monotherapy in patients with primary biliary cholangitis

Kris V. Kowdley et al.

HEPATOLOGY (2018)

Article Gastroenterology & Hepatology

EASL Clinical Practice Guidelines: The diagnosis and management of patients with primary biliary cholangitis

Gideon M. Hirschfield et al.

JOURNAL OF HEPATOLOGY (2017)

Article Biochemistry & Molecular Biology

WebGestalt 2017: a more comprehensive, powerful, flexible and interactive gene set enrichment analysis toolkit

Jing Wang et al.

NUCLEIC ACIDS RESEARCH (2017)

Article Multidisciplinary Sciences

A genome-wide association study identifies six novel risk loci for primary biliary cholangitis

Fang Qiu et al.

NATURE COMMUNICATIONS (2017)

Article Medicine, General & Internal

Ustekinumab as Induction and Maintenance Therapy for Crohn's Disease

B. G. Feagan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Gastroenterology & Hepatology

Obeticholic acid for the treatment of primary biliary cirrhosis

David E. J. Jones

EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY (2016)

Article Multidisciplinary Sciences

Network Propagation with Dual Flow for Gene Prioritization

Shunyao Wu et al.

PLOS ONE (2015)

Review Gastroenterology & Hepatology

Review article: controversies in the management of primary biliary cirrhosis and primary sclerosing cholangitis

T. H. Karlsen et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2014)

Article Pathology

The Immunobiology and Pathophysiology of Primary Biliary Cirrhosis

Gideon M. Hirschfield et al.

Annual Review of Pathology-Mechanisms of Disease (2013)

Article Gastroenterology & Hepatology

Randomized controlled trial assessing the effect of simvastatin in primary biliary cirrhosis

William J. Cash et al.

LIVER INTERNATIONAL (2013)

Article Gastroenterology & Hepatology

Muromonab-CD3 therapy for refractory rejections after liver transplantation: a single-center experience during two decades in Japan

Daisuke Ueda et al.

JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES (2010)

Review Gastroenterology & Hepatology

Primary Biliary Cirrhosis

Keith D. Lindor et al.

HEPATOLOGY (2009)

Review Gastroenterology & Hepatology

EASL Clinical Practice Guidelines: Management of cholestatic liver diseases

Ulrich Beuers et al.

JOURNAL OF HEPATOLOGY (2009)

Article Biochemistry & Molecular Biology

BioGRID: a general repository for interaction datasets

Chris Stark et al.

NUCLEIC ACIDS RESEARCH (2006)

Article Biotechnology & Applied Microbiology

Drug repositioning: Identifying and developing new uses for existing drugs

TT Ashburn et al.

NATURE REVIEWS DRUG DISCOVERY (2004)

Article Gastroenterology & Hepatology

Tamoxifen: a novel treatment for primary biliary cirrhosis?

A Reddy et al.

LIVER INTERNATIONAL (2004)

Article Cardiac & Cardiovascular Systems

Inflammation as a therapeutic target: A unique role for abciximab

DJ Kereiakes

AMERICAN HEART JOURNAL (2003)

Article Genetics & Heredity

The HUGO Gene Nomenclature Committee (HGNC)

S Povey et al.

HUMAN GENETICS (2001)