4.7 Review

PD-1/PD-L1 Pathway: A Therapeutic Target in CD30+ Large Cell Lymphomas

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Successful treatment of refractory retroperitoneal Epstein-Barr virus-positive diffuse large B-cell lymphoma with secondary hemophagocytic syndrome by sequential combination regimen of PD-1 blockade and chimeric antigen receptor T cells: a case report

Min Yu et al.

Summary: This study reported an atypical case of EBV-positive DLBCL in an immunocompetent young male patient. Through multiple treatment adjustments, including PD-1 blockade and CAR-T cell therapy, complete remission was eventually achieved.

ANTI-CANCER DRUGS (2022)

Review Hematology

Primary mediastinal large B-cell lymphoma

Kerry J. Savage

Summary: This article discusses the unique features of PMBCL and the choice of treatment options. Accurate diagnosis can be made based on clinical information and molecular classifiers, and emerging data suggest the high efficacy of PD1 inhibitors in PMBCL treatment.
Article Hematology

Pembrolizumab followed by AVD in untreated early unfavorable and advanced-stage classical Hodgkin lymphoma

Pamela B. Allen et al.

Summary: Brief pembrolizumab monotherapy followed by AVD is highly effective and safe for patients with newly diagnosed classical Hodgkin lymphoma, including those with bulky disease.
Article Oncology

Next generation sequencing of breast implant-associated anaplastic large cell lymphomas reveals a novel STAT3-JAK2 fusion among other activating genetic alterations within the JAK-STAT pathway

Andres E. Quesada et al.

Summary: Breast implant associated anaplastic large cell lymphoma (BIA-ALCL) is a distinct subtype characterized by genetic absence of fusions and frequent activation of the JAK-STAT3 pathway. Genetic profiling of BIA-ALCL cases revealed activation of the STAT3-JAK2 fusion, providing further insight into potential targeted therapy options for advanced cases.

BREAST JOURNAL (2021)

Article Oncology

PD-L1 expression in peripheral T-cell lymphomas is not related to either PD-L1 gene amplification or rearrangements

Rebeca Manso et al.

Summary: In this study, immunohistochemistry and FISH studies were conducted on n-PTCL samples to investigate the expression of PD-1, p-STAT3, and PD-L1, as well as genetic abnormalities of chromosome 9p. PD-L1 (clone 263) was most commonly detected in both tumor cells and the microenvironment, with some cases showing polyploidy in chromosome 9. PD-L1 expression correlated with p-STAT3 in tumor cells, while PD-1 expression was associated with PD-L1 expression in the microenvironment. Overall, the presence of PD-L1 on tumor cells or in the microenvironment suggests potential benefits of immune check-point modulation therapy in some n-PTCL cases.

LEUKEMIA & LYMPHOMA (2021)

Review Hematology

Immunity reloaded: Deconstruction of the PD-1 axis in B cell lymphomas

Karolina Bednarska et al.

Summary: Therapies targeting the PD-1 axis have revolutionized the clinical management of some cancers over the past decade, but their impact on B cell lymphomas varies greatly, indicating the need for more nuanced approaches to enhance treatment efficacy.

BLOOD REVIEWS (2021)

Article Hematology

EBV-positive HIV-associated diffuse large B cell lymphomas are characterized by JAK/STAT (STAT3) pathway mutations and unique clinicopathologic features

Jennifer R. Chapman et al.

Summary: In the era of cART, approximately half of HIV-DLBCL are EBV-related. HIV-DLBCL are enriched for MYC rearrangements and mutations, and lack BCL2 rearrangements regardless of EBV status. EBV-negative and EBV-positive HIV-DLBCL show important genetic and clinical differences, with the former having more mutations and higher mutation frequency for genes like TP53, SGK1, and EP300, while the latter occur in lower CD4 count, non-GCB origin, and recurrent STAT3 mutations.

BRITISH JOURNAL OF HAEMATOLOGY (2021)

Article Pathology

Breast implant-associated anaplastic large cell lymphoma: clinical follow-up and analysis of sequential pathologic specimens of untreated patients shows persistent or progressive disease

Mark G. Evans et al.

Summary: This study analyzed sequential pathologic specimens from patients with breast implant-associated ALCL, revealing that these neoplasms persist or progress over time if not treated with standard-of-care therapy.

MODERN PATHOLOGY (2021)

Review Oncology

EBV-positive B-cell lymphomas and lymphoproliferative disorders: Review from the perspective of immune escape and immunodeficiency

Akira Satou et al.

Summary: The Epstein-Barr virus (EBV) is detected in a variety of B-cell lymphomas (BCLs) and B-cell lymphoproliferative disorders (B-LPDs), with immunodeficiency and immune escape playing key roles in their pathogenesis. The PD-1/PD-L1 pathway is crucial for immune escape, and PD-L1 immunohistochemistry (IHC) is a useful method for predicting immune escape mechanisms in lymphoid malignancies. Immune checkpoint inhibitors have shown promise in treating lymphomas characterized by immune escape, making them good candidates for PD1/PD-L1 blockade therapy.

CANCER MEDICINE (2021)

Review Oncology

The PD-1/PD-L1 Checkpoint in Normal Germinal Centers and Diffuse Large B-Cell Lymphomas

Marcos Garcia-Lacarte et al.

Summary: The PD-1/PD-L1 axis is crucial in both anti-tumor immune evasion and regulation of normal germinal center reactions. In DLBCL, malignant B cells exploit interactions between PD-1/PD-L1 to establish an immunosuppressive microenvironment and evade cytotoxic activity. This highlights the potential for novel combination immunotherapies targeting vulnerabilities in the complex inter-cellular interactions involving PD-1/PD-L1.

CANCERS (2021)

Article Hematology

Avelumab in relapsed/refractory classical Hodgkin lymphoma: phase 1b results from the JAVELIN Hodgkins trial

Alex F. Herrera et al.

Summary: The study investigated the use of avelumab in patients with relapsed/refractory cHL and found that it was well tolerated and showed anti-tumor activity even in heavily pretreated patients. PD-L1 blockade may be sufficient for therapeutic benefit in cHL patients.

BLOOD ADVANCES (2021)

Article Hematology

Clinicopathological features and survival in EBV-positive diffuse large B-cell lymphoma not otherwise specified

Estelle Bourbon et al.

Summary: This retrospective study reported 70 cases of EBV(+) diffuse large B-cell lymphoma, with a median age of 68.5 years. Patients were mainly treated with immunochemotherapy or chemotherapy. Older age and HLH were associated with shorter PFS and OS.

BLOOD ADVANCES (2021)

Review Hematology

Current and emerging treatment options in primary mediastinal B-cell lymphoma

Bita Fakhri et al.

Summary: PMBCL, previously considered a subtype of DLBCL, is now recognized as an independent entity with unique molecular features. DA-EPOCH-R is the preferred frontline regimen with impressive outcomes, but relapsed/refractory cases still have poor prognosis. Innovative approaches including PD-1 inhibitors, CAR T-cell therapy, and BV in combination with PD-1 inhibitors show promise in treating rrPMBCL.

THERAPEUTIC ADVANCES IN HEMATOLOGY (2021)

Review Oncology

Checkpoint Inhibition Therapy in Transplant-Ineligible Relapsed or Refractory Classic Hodgkin Lymphoma

Samer A. Al-Hadidi et al.

Summary: Checkpoint inhibitors nivolumab and pembrolizumab are key treatment options for relapsed or refractory classic Hodgkin lymphoma, especially for patients unable to undergo stem-cell transplantation. These drugs may improve overall survival and have manageable side effects.

JCO ONCOLOGY PRACTICE (2021)

Article Oncology

T-cell lymphoma secondary to checkpoint inhibitor therapy

Kartik Anand et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

Letter Hematology

Identification of high-risk DUSP22-rearranged ALK-negative anaplastic large cell lymphoma

Greg Hapgood et al.

BRITISH JOURNAL OF HAEMATOLOGY (2019)

Article Oncology

STAT-3 RNAscope Determination in Human Diffuse Large B-Cell Lymphoma

Roberto Tamma et al.

TRANSLATIONAL ONCOLOGY (2019)

Article Oncology

Pembrolizumab in Relapsed or Refractory Primary Mediastinal Large B-Cell Lymphoma

Philippe Armand et al.

JOURNAL OF CLINICAL ONCOLOGY (2019)

Review Oncology

Hodgkin Lymphoma: A Review and Update on Recent Progress

Satish Shanbhag et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2018)

Review Hematology

PD-1 expression and clinical PD-1 blockade in B-cell lymphomas

Zijun Y. Xu-Monette et al.

Article Medicine, Research & Experimental

Clinicopathologic implication of PD-L1 and phosphorylated STAT3 expression in diffuse large B cell lymphoma

Hyun Jung Kwon et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2018)

Review Immunology

PD-1/PD-L1 inhibitors in haematological malignancies: update 2017

Tomas Jelinek et al.

IMMUNOLOGY (2017)

Review Biochemistry & Molecular Biology

Structural Biology of the Immune Checkpoint Receptor PD-1 and Its Ligands PD-L1/PD-L2

Krzysztof M. Zak et al.

STRUCTURE (2017)

Letter Medicine, General & Internal

Nivolumab for Refractory Anaplastic Large Cell Lymphoma: A Case Report

Holger Hebart et al.

ANNALS OF INTERNAL MEDICINE (2016)

Article Hematology

Genetic basis of PD-L1 overexpression in diffuse large B-cell lymphomas

Konstantinos Georgiou et al.

Article Oncology

PD-L1 and PD-L2 Genetic Alterations Define Classical Hodgkin Lymphoma and Predict Outcome

Margaretha G. M. Roemer et al.

JOURNAL OF CLINICAL ONCOLOGY (2016)

Article Multidisciplinary Sciences

Aberrant PD-L1 expression through 3′-UTR disruption in multiple cancers

Keisuke Kataoka et al.

NATURE (2016)

Review Immunology

The PD1:PD-L1/2 Pathway from Discovery to Clinical implementation

Kankana Bardhan et al.

FRONTIERS IN IMMUNOLOGY (2016)

Article Medicine, General & Internal

PD-1 Blockade with Nivolumab in Relapsed or Refractory Hodgkin's Lymphoma

Stephen M. Ansell et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Multidisciplinary Sciences

MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers

Christian Steidl et al.

NATURE (2011)

Article Medicine, General & Internal

Tumor-Associated Macrophages and Survival in Classic Hodgkin's Lymphoma

Christian Steidl et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Article Hematology

B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells

Takeshi Azuma et al.

Article Multidisciplinary Sciences

Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)

Michal Marzec et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Medicine, General & Internal

CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma.

B Coiffier et al.

NEW ENGLAND JOURNAL OF MEDICINE (2002)

Article Immunology

PD-L2 is a second ligand for PD-I and inhibits T cell activation

Y Latchman et al.

NATURE IMMUNOLOGY (2001)