期刊
CLINICAL PSYCHOLOGICAL SCIENCE
卷 11, 期 1, 页码 77-89出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/21677026221103136
关键词
theta-burst stimulation; transcranial magnetic stimulation; compulsive behaviors; obsessive-compulsive disorder; orbitofrontal cortex
Compulsive behaviors are linked to orbitofrontal cortex function. The study shows that intermittent theta-burst stimulation (iTBS) leads to increased functional connectivity between the orbitofrontal cortex and other regions compared to continuous TBS (cTBS).
Compulsive behaviors (CBs) have been linked to orbitofrontal cortex (OFC) function in animal and human studies. However, brain regions function not in isolation but as components of widely distributed brain networks-such as those indexed via resting-state functional connectivity (RSFC). Sixty-nine individuals with CB disorders were randomized to receive a single session of neuromodulation targeting the left OFC-intermittent theta-burst stimulation (iTBS) or continuous TBS (cTBS)-followed immediately by computer-based behavioral habit override training. OFC seeds were used to quantify RSFC following iTBS and following cTBS. Relative to cTBS, iTBS showed increased RSFC between right OFC (Brodmann's area 47) and other areas, including dorsomedial prefrontal cortex (dmPFC), occipital cortex, and a priori dorsal and ventral striatal regions. RSFC connectivity effects were correlated with OFC/frontopolar target engagement and with subjective difficulty during habit-override training. Findings help reveal neural network-level impacts of neuromodulation paired with a specific behavioral context, informing mechanistic intervention development.
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