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Advances in extracellular vesicle functionalization strategies for tissue regeneration

BIOACTIVE MATERIALS (2023)

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Article Pharmacology & Pharmacy

Click chemistry extracellular vesicle/peptide/chemokine nanocarriers for treating central nervous system injuries

Huitong Ruan et al.

Summary: In this research, extracellular vesicles (EVs) secreted by M2 microglia were used to improve the differentiation of neural stem cells (NSCs) at the injured site. The EVs were modified with the injured vascular targeting peptide (DA7R) and the stem cell recruiting factor (SDF-1) to recruit NSCs, induce their neuronal differentiation, and serve as nanocarriers at the injured site. The results showed that the modified EVs could target human umbilical vascular endothelial cells (HUVECs), recruit NSCs, and promote their neuronal differentiation. Furthermore, certain upregulated miRNAs in the EVs were found to induce NSCs to differentiate into neurons.

ACTA PHARMACEUTICA SINICA B (2023)

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Article Chemistry, Multidisciplinary

Osteoblast/Osteoclast and Immune Cocktail Therapy of an Exosome/Drug Delivery Multifunctional Hydrogel Accelerates Fracture Repair

Bobin Mi et al.

Summary: The ratios of osteoblast/osteoclast and M1/M2 macrophages are crucial for fracture healing. This study developed a cocktail therapy to simultaneously regulate the balance of these cells, leading to enhanced fracture repair. Each component of the cocktail therapy was found to be indispensable, providing insight into synergistic strategies for fracture repair.

ACS NANO (2022)

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Article Engineering, Environmental

Metformin-hydrogel with glucose responsiveness for chronic inflammatory suppression

Dandan Zheng et al.

Summary: A glucose-responsive drug delivery system was developed to deliver metformin for anti-inflammation effect under high glucose conditions, promoting tissue regeneration in diabetes-induced intervertebral disc degeneration model rats. The system adjusted metformin release in response to glucose concentrations, protected mitochondria from ROS damage, inhibited inflammatory pathways, and stimulated extracellular matrix synthesis, ensuring smooth tissue regeneration under diabetic conditions.

CHEMICAL ENGINEERING JOURNAL (2022)

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Article Medicine, Research & Experimental

Drug Loading and Functional Efficacy of Cow, Buffalo, and Goat Milk-Derived Exosomes: A Comparative Study

Farhan Ahmed et al.

Summary: In this study, milk exosomes derived from cow, buffalo, and goat were isolated and characterized, and their drug loading capacity and functional efficiency were evaluated in HepG2, HCT116, and A549 cells using doxorubicin. The results showed that goat milk exosomes had the highest drug loading capacity and exhibited stronger inhibitory effects on cell viability and induction of apoptosis compared to cow and buffalo milk exosomes.

MOLECULAR PHARMACEUTICS (2022)

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Article Multidisciplinary Sciences

MicroRNA sequence codes for small extracellular vesicle release and cellular retention

Ruben Garcia-Martin et al.

Summary: Research has shown that miRNAs have sorting sequences that determine their secretion in sEVs, different cell types preferentially use specific sorting sequences to define their sEV miRNA profile. Insertion or deletion of these sequences affects miRNA secretion. RNA-binding proteins Alyref and Fus are involved in the mechanism, leading to enhanced miRNA delivery and inhibition of target genes in distant cells.

NATURE (2022)

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Article Medicine, Research & Experimental

Exosome-mediated delivery of RBP-J decoy oligodeoxynucleotides ameliorates hepatic fibrosis in mice

Fei He et al.

Summary: This study demonstrates that the infusion of exosomes loaded with RBP-J decoy oligodeoxynucleotides (ODNs) can efficiently inhibit Notch signaling in macrophages and ameliorate hepatic fibrosis in mice, suggesting a promising therapeutic strategy for the treatment of hepatic fibrosis.

THERANOSTICS (2022)

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Article Multidisciplinary Sciences

Injectable hydrogel microspheres with self-renewable hydration layers alleviate osteoarthritis

Yiting Lei et al.

Summary: Researchers have developed a new type of hyaluronic acid-based HMs with rapamycin-liposome coating, which can form self-renewable hydration layers and release autophagy activator for improving joint lubrication, maintaining cellular homeostasis, and alleviating joint wear and osteoarthritis progression.

SCIENCE ADVANCES (2022)

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Article Engineering, Biomedical

Encapsulation of Hydrophilic Compounds in Small Extracellular Vesicles: Loading Capacity and Impact on Vesicle Functions

Britta Franziska Hettich et al.

Summary: Different methods were explored to incorporate hydrophilic non-membrane permeable compounds into stem cell-derived small EV, with freeze-thawing and osmotic shock proving to be the most appropriate methods for high drug encapsulation while preserving structural and biological vesicle characteristics.

ADVANCED HEALTHCARE MATERIALS (2022)

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Article Engineering, Biomedical

Functional siRNA Delivery by Extracellular Vesicle-Liposome Hybrid Nanoparticles

Martijn J. W. Evers et al.

Summary: EV-liposome hybrid nanoparticles have been investigated as a potential siRNA delivery system, demonstrating their ability to encapsulate siRNA, contain EV-surface markers, and functionally deliver siRNA to different cell types. These hybrids combine the benefits of both synthetic and biological drug delivery systems, showing altered functional behavior compared to liposomes and varying efficacy among recipient cell types.

ADVANCED HEALTHCARE MATERIALS (2022)

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Article Cell & Tissue Engineering

Hypoxic mesenchymal stem cell-derived extracellular vesicles ameliorate renal fibrosis after ischemia-reperfusion injure by restoring CPT1A mediated fatty acid oxidation

Zhumei Gao et al.

Summary: Hypo-EVs show superior therapeutic effects in repairing renal structure damage, restoring renal function, and reducing renal fibrosis. They enhance mitochondrial FAO by restoring the expression of the key enzyme CPT1A, leading to improved mitochondrial homeostasis and attenuation of I/R damage.

STEM CELL RESEARCH & THERAPY (2022)

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Article Biotechnology & Applied Microbiology

Engineering stem cells to produce exosomes with enhanced bone regeneration effects: an alternative strategy for gene therapy

Feiyang Li et al.

Summary: A stem cell-mediated gene therapy strategy was developed in this study, where genetically engineered mesenchymal stem cells were used to produce exosomes with enhanced bone regeneration potency. These engineered exosomes exhibited homing ability to the injured site and showed potential clinical applications.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Article Engineering, Biomedical

Exosome-loaded extracellular matrix-mimic hydrogel with anti-inflammatory property Facilitates/promotes growth plate injury repair

Pengfei Guan et al.

Summary: Growth plate cartilage has limited self-repair ability, leading to poor bone bridge formation and limb growth defects in children. The researchers developed an exosome-derived hydrogel that directly supplements extracellular matrix and inhibits inflammation to promote cartilage repair. The hydrogel significantly enhanced extracellular matrix synthesis and facilitated growth plate injury repair through ECM remodeling.

BIOACTIVE MATERIALS (2022)

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Article Cell Biology

Tumour-derived extracellular vesicle membrane hybrid lipid nanovesicles enhance siRNA delivery by tumour-homing and intracellular freeway transportation

Xin Zhou et al.

Summary: This study successfully isolated TDEV membranes from hepatocellular carcinoma cells and fabricated innovative TDEV membrane hybrid lipid nanovesicles (LEVs) for precise delivery to tumors and efficient siRNA transfection. The LEVs, equipped with 'homing' targeting ability, showed improved siRNA delivery efficiency compared to liposomes. In animal experiments, siRNA loaded LEVs demonstrated enhanced antitumor efficacy in hepatocellular carcinoma tumors.

JOURNAL OF EXTRACELLULAR VESICLES (2022)

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Article Cell Biology

Analysis of extracellular vesicle DNA at the single-vesicle level by nano-flow cytometry

Haisheng Liu et al.

Summary: This study provides direct and conclusive experimental evidence for an in-depth understanding of how DNA is associated with extracellular vesicles (EVs). The study reveals that EVs carry naked DNA or DNA associated with non-vesicular entities. The quantity and distribution of EV-DNA vary depending on the cell type, with a high heterogeneity observed. The study also shows that external EV-DNA is mainly localized on smaller EVs, while internal EV-DNA is packaged inside larger EVs. The predominant form of EV-DNA is double-stranded DNA, and it is not associated with histone proteins.

JOURNAL OF EXTRACELLULAR VESICLES (2022)

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Review Chemistry, Multidisciplinary

Label-Free Isolation of Exosomes Using Microfluidic Technologies

Sara Hassanpour Tamrin et al.

Summary: Exosomes are cell-derived structures containing lipids, proteins, and nucleic acids, playing roles in physiological and pathological processes. Microfluidic technology offers simple, cost-effective, precise, and fast processing for exosome isolation, yet faces challenges hindering their clinical utility.

ACS NANO (2021)

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Article Chemistry, Multidisciplinary

Anti-Friction MSCs Delivery System Improves the Therapy for Severe Osteoarthritis

Xin Yan et al.

Summary: The DNA supramolecular hydrogel has been shown to provide excellent protection for MSCs against shear forces, promoting quality cartilage formation, reducing osteophyte formation, and normalizing subchondral bone under high friction conditions of OA. This material has potential as a promising cell delivery system for various MSCs therapies.

ADVANCED MATERIALS (2021)

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Article Engineering, Biomedical

Exosomes from TNF-α-treated human gingiva-derived MSCs enhance M2 macrophage polarization and inhibit periodontal bone loss

Yuki Nakao et al.

Summary: Preconditioning gingival tissue-derived MSCs (GMSCs) with tumor necrosis factor-alpha (TNF-alpha) enhances the secretion of exosomes and the expression of CD73, promoting antiinflammatory M2 macrophage polarization. GMSC-derived exosomes exhibit significant ability to regulate inflammation and osteoclastogenesis, providing a potential therapeutic approach for periodontitis. The findings suggest a promising strategy for treating inflammatory osteoimmune disorders using TNF-alpha-preconditioned GMSC-derived exosomes.

ACTA BIOMATERIALIA (2021)

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Article Engineering, Biomedical

Hypoxic pretreatment of small extracellular vesicles mediates cartilage repair in osteoarthritis by delivering miR-216a-5p

Yuluo Rong et al.

Summary: The study demonstrated that hypoxic pretreatment of small extracellular vesicles effectively protected cartilage from degeneration and slowed down the progression of OA. Through the miR-216a-5p/JAK2/STAT3 pathway, hypoxic pretreatment is promising for optimizing the therapeutic effects of BMSC-derived sEVs.

ACTA BIOMATERIALIA (2021)

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Article Engineering, Biomedical

Human neutrophil membrane-derived nanovesicles as a drug delivery platform for improved therapy of infectious diseases

Jin Gao et al.

Summary: The study demonstrates that nanovesicles derived from human neutrophil membrane can enhance inflammation resolution and bacterial killing, providing a new approach for the treatment of infectious diseases.

ACTA BIOMATERIALIA (2021)

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Article Engineering, Environmental

Stapled RAP12 peptide ligand of LRP1 for micelles-based multifunctional glioma-targeted drug delivery

Huitong Ruan et al.

Summary: By optimizing the structure and stability of RAP12 peptide, a novel ST-RAP12 peptide was developed with enhanced α-helical content, binding affinity, and cellular internalization, showing promising capabilities in penetrating the blood-brain barrier and targeting glioma. ST-RAP12 was also utilized to construct micelles for effective drug delivery to glioma cells, demonstrating significant anti-cancer efficacy.

CHEMICAL ENGINEERING JOURNAL (2021)

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Review Engineering, Biomedical

Extracellular vesicles: A bright star of nanomedicine

Peipei Wu et al.

Summary: Extracellular vesicles play a crucial role in disease treatment and diagnosis, with engineered design enhancing their therapeutic capability and diagnostic imaging potential.

BIOMATERIALS (2021)

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Article Engineering, Biomedical

Dissecting the effects of preconditioning with inflammatory cytokines and hypoxia on the angiogenic potential of mesenchymal stromal cell (MSC)-derived soluble proteins and extracellular vesicles (EVs)

Cansu Gorgun et al.

Summary: The research demonstrates that the MSC secretome is strongly modulated by concurrent stimulation with hypoxia and pro-inflammatory cytokines, which mimics the harsh environment at the injury site. The environmental variations strongly influence the angiogenic potential of different secretome fractions.

BIOMATERIALS (2021)

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Article Engineering, Biomedical

A near-infrared light-responsive extracellular vesicle as a Trojan horse for tumor deep penetration and imaging-guided therapy

Zeng Xu et al.

Summary: Developed a near-infrared light-responsive extracellular vesicle nanoplatform that can deeply penetrate tumor tissues and be rapidly eliminated from the body post-treatment, enhancing therapeutic efficacy. Similar to a Trojan horse, the nanoplatform hides anti-tumor agents in macrophage cell-secreted vesicles and utilizes NIR fluorescence imaging for in vivo biodistribution monitoring.

BIOMATERIALS (2021)

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Article Chemistry, Multidisciplinary

Electrospun Fibers Improving Cellular Respiration via Mitochondrial Protection

Wei Chen et al.

Summary: The study utilized electrospun fibers loaded with Hif-1 pathway activator to improve cellular respiration of BMSCs in diabetic fractures, potentially enhancing cell survival and function by protecting mitochondrial function and reconstructing microcirculation.

SMALL (2021)

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Article Multidisciplinary Sciences

Minimally invasive delivery of therapeutic agents by hydrogel injection into the pericardial cavity for cardiac repair

Dashuai Zhu et al.

Summary: Intrapericardial injection is established as a safe and effective method for delivering therapeutic-bearing hydrogels to the heart, promoting cardiac repair.

NATURE COMMUNICATIONS (2021)

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Review Cell & Tissue Engineering

The Role of Mechanical Regulation in Cartilage Tissue Engineering

Shujiang Zhang et al.

Summary: Cartilage tissue cannot self-repair due to lack of vascular distribution and slow metabolism. Stem cell tissue engineering shows promise for cartilage repair. Mechanical stimulation has been shown to enhance quality of engineered cartilage, making it more similar to natural cartilage in structure and function.

CURRENT STEM CELL RESEARCH & THERAPY (2021)

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Article Dentistry, Oral Surgery & Medicine

Exosomes derived from 3D-cultured MSCs improve therapeutic effects in periodontitis and experimental colitis and restore the Th17 cell/Treg balance in inflamed periodontium

Yong Zhang et al.

Summary: Our study demonstrated that exosomes derived from mesenchymal stem cells (MSCs) cultured in a 3D system (3D-exos) have enhanced anti-inflammatory effects in periodontitis compared to those from a traditional 2D culture system (2D-exos). This improvement is mediated by the increased expression of miR-1246 in 3D-exos, which suppresses Nfat5 expression and restores the Th17 cell/Treg balance in inflamed periodontal tissues. Furthermore, local injection of 3D-exos also attenuated experimental colitis by rebalancing immune responses.

INTERNATIONAL JOURNAL OF ORAL SCIENCE (2021)

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Article Cell Biology

Bioorthogonally surface-edited extracellular vesicles based on metabolic glycoengineering for CD44-mediated targeting of inflammatory diseases

Gyeong Taek Lim et al.

Summary: This study successfully prepared surface-edited EVs using bioorthogonal copper-free click chemistry and metabolic glycoengineering, which effectively accumulated in target tissues in animal models, primarily due to prolonged circulation in the bloodstream and active targeting mechanism.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

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Article Biotechnology & Applied Microbiology

Engineered extracellular vesicles derived from primary M2 macrophages with anti-inflammatory and neuroprotective properties for the treatment of spinal cord injury

Chuanjie Zhang et al.

Summary: Engineered extracellular vesicles with anti-inflammatory and neuroprotective properties were prepared by combining nerve growth factor (NGF) and curcumin (Cur). These vesicles effectively accumulated at the injured site, inhibiting inflammation and releasing NGF for neuroprotection. The vesicles significantly improved the microenvironment after injury and promoted the recovery of motor function after SCI.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Agriculture, Multidisciplinary

Enhanced Neuroprotective Effects of Epicatechin Gallate Encapsulated by Bovine Milk-Derived Exosomes against Parkinson's Disease through Antiapoptosis and Antimitophagy

Siqi Luo et al.

Summary: A new exosome-based delivery system for ECG was designed and studied for its neuroprotective effects in a PD model, showing successful delivery of ECG into cells and enhanced neuroprotection against Rot-induced damage.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

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Article Cell Biology

Active cargo loading into extracellular vesicles: Highlights the heterogeneous encapsulation behaviour

Chaoxiang Chen et al.

Summary: Extracellular vesicles have unique advantages as nanocarriers for drug delivery, but their cargo encapsulation efficiency is often below expectations, especially for hydrophilic chemotherapeutic drugs. This study introduced a new method named SEAL, which significantly enhances drug encapsulation efficiency of EVs, and single-particle analysis techniques were used to uncover the encapsulation heterogeneity of EVs.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

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Article Engineering, Biomedical

Small extracellular vesicles in combination with sleep-related circRNA3503: A targeted therapeutic agent with injectable thermosensitive hydrogel to prevent osteoarthritis

Shi-Cong Tao et al.

Summary: OA is a common age-related degenerative joint disease with disturbance of ECM balance. CircRNA3503, increased after MT-induced cell sleep, acts as a sponge of hsa-miR-181c-3p and hsa-let-7b-3p to rescue IL-1 beta effects on OA. PLEL@circRNA3503-OE-sEVs show potential as an effective therapeutic strategy to prevent OA progression.

BIOACTIVE MATERIALS (2021)

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Article Engineering, Biomedical

Capturing dynamic biological signals via bio-mimicking hydrogel for precise remodeling of soft tissue

Zhengwei Cai et al.

Summary: The bio-mimicking hydrogel designed through thiol-ene click reaction captures early physical and chemical signals to facilitate cell anchoring, migration, and invasion in a 3D matrix, and promotes endothelial cell functional differentiation through HIF-1α dependent signaling pathway.

BIOACTIVE MATERIALS (2021)

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Article Cell Biology

Adipose-Derived Mesenchymal Stromal Cells Treated with Interleukin 1 Beta Produced Chondro-Protective Vesicles Able to Fast Penetrate in Cartilage

Alessandra Colombini et al.

Summary: The study aimed to explore the miRNA cargo in extracellular vesicles and their interaction with cartilage, revealing that ASCs preconditioned with IL-1 beta can release EVs embedded with chondro-protective miRNA that quickly penetrate cartilage and saturate tissue within a day. Further functional studies are needed to determine the dose-effects of EVs for clinical relevance.

CELLS (2021)

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Review Pharmacology & Pharmacy

Extracellular vesicles as delivery systems at nano-/micro-scale

Peiwen Fu et al.

Summary: Extracellular vesicles (EVs) have shown significant promises as nano-/micro-size carriers in drug delivery and bioimaging, possessing unique physicochemical properties, biological features, and mechanical aspects. This review analyzes the pros and cons of EVs as a delivery platform, elaborates on rational design improvements, and compares pharmaceutical loading approaches, aiming to construct a clinically available and effective nano-/micro-carrier.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Review Pharmacology & Pharmacy

A call for the standardised reporting of factors affecting the exogenous loading of extracellular vesicles with therapeutic cargos

Stephanie Rankin-Turner et al.

Summary: Extracellular vesicles (EVs) are complex nanoparticles that have shown potential as natural platforms for enhanced therapeutic delivery across biological barriers. However, there is currently no standard reporting framework established for therapeutic loading of EVs for drug delivery applications.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Article Engineering, Biomedical

Mononuclear phagocyte system blockade using extracellular vesicles modified with CD47 on membrane surface for myocardial infarction reperfusion injury treatment

Zilun Wei et al.

Summary: The study demonstrated that enhancing the biodistribution of CD47-EVs in the heart could potentially serve as a therapeutic approach to alleviate myocardial ischemia-reperfusion injury.

BIOMATERIALS (2021)

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Article Medicine, Research & Experimental

A human chorionic gonadotropin (hCG) delivery platform using engineered uterine exosomes to improve endometrial receptivity

Hamed Hajipour et al.

Summary: This study demonstrated the potential of uterine fluid-derived exosomes as a carrier for delivering hCG to endometrial cells, enhancing endometrial receptivity. The effect of hCG-loaded exosomes on endometrial receptivity exceeded that of hCG or exosomes alone. Furthermore, hCG-loaded exosomes showed enhanced regulation of specific gene expression compared to hCG alone.

LIFE SCIENCES (2021)

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Article Neurosciences

Oligodendrocytes enhance axonal energy metabolism by deacetylation of mitochondrial proteins through transcellular delivery of SIRT2

Kelly A. Chamberlain et al.

Summary: This study reveals a transcellular signaling mechanism by which oligodendrocytes deliver SIRT2 to axons to enhance energy metabolism, promoting ATP production through deacetylation of mitochondrial proteins. The transcellular delivery of SIRT2 is crucial for maintaining axonal energy enhancement, providing a potential target for boosting bioenergetic metabolism in neurological disorders. Delivery of SIRT2-filled exosomes into myelinated axons rescues mitochondrial integrity and demonstrates the importance of intercellular communication in supporting axonal function.

NEURON (2021)

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Article Multidisciplinary Sciences

Extracellular vesicles derived from DFO-preconditioned canine AT-MSCs reprogram macrophages into M2 phase

Su-Min Park et al.

Summary: The study revealed that DFO preconditioning in MSCs activated the HIF-1 alpha/COX-2 signaling pathway, leading to increased accumulation of HIF-1 alpha and activation of COX-2 in MSCDFO. EVs derived from MSCDFO were enriched with COX-2 protein, and transferring COX-2 through EVs effectively reprogrammed macrophages into M2 phase by promoting the phosphorylation of STAT3.

PLOS ONE (2021)

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Review Chemistry, Multidisciplinary

Bone-a-Petite: Engineering Exosomes towards Bone, Osteochondral, and Cartilage Repair

Ho Pan Bei et al.

Summary: Exosomes have emerged as a powerful tool for tissue repair with their complex content and ability to target specific cells, offering potential for enhanced bone, osteochondral, and cartilage regeneration. Engineering applications can further optimize exosomes for various functions through physical, chemical, and biological modulations.

SMALL (2021)

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Article Biotechnology & Applied Microbiology

Injectable exosome-functionalized extracellular matrix hydrogel for metabolism balance and pyroptosis regulation in intervertebral disc degeneration

Hongyuan Xing et al.

Summary: Exosome therapy is a promising approach for treating intervertebral disc degeneration (IVDD) by regulating metabolic disorders, the microenvironment, and cell homeostasis through sustained release of microRNAs, proteins, and transcription factors. The thermosensitive dECM@exo hydrogel system, coupled with adipose-derived mesenchymal stem cell exosomes, provides in situ gelation to replenish ECM leakage in nucleus pulposus cells and environment for their growth, while regulating matrix synthesis, degradation, and inhibiting inflammatory responses. Animal studies show that this system helps maintain early IVD microenvironment homeostasis and can potentially serve as a powerful platform for drug delivery and therapy for IVDD.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Cell Biology

Small extracellular vesicles released by infused mesenchymal stromal cells target M2 macrophages and promote TGF-β upregulation, microvascular stabilization and functional recovery in a rodent model of severe spinal cord injury

Masahito Nakazaki et al.

Summary: Intravenous infusion of bone marrow-derived mesenchymal stem/stromal cells (MSCs) leads to the release of small extracellular vesicles (sEVs) that can target the injury site in spinal cord injury (SCI) rats and interact with M2 macrophages. Fractionated dosing of MSC-sEVs over 3 days is required to achieve therapeutic effects, mimicking the results of single MSC infusion. These findings suggest that the release of sEVs by MSCs over time induces a cascade of cellular responses leading to improved functional recovery.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

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Article Cell Biology

Exogenous loading of miRNAs into small extracellular vesicles

Ricardo C. Abreu et al.

Summary: The study demonstrates that Exo-Fect is the most efficient method for modulating sEVs, leading to over 1000-fold upregulation of the miRNA of interest and successful delivery of miR-155-5p into target cells, demonstrating its functionality. Furthermore, the membrane alterations in Exo-Fect-loaded sEVs enhance internalization within target cells and decrease interaction with lysosomes.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

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Article Cell & Tissue Engineering

Lithium modulates miR-1906 levels of mesenchymal stem cell-derived extracellular vesicles contributing to poststroke neuroprotection by toll-like receptor 4 regulation

Matteo Haupt et al.

Summary: Preconditioning of MSCs with lithium enhances the therapeutic potential of EVs, specifically Li-EVs, which show increased resistance against hypoxic injury and improved neurological recovery in poststroke models. Additionally, Li-EVs modify the contents of miRNAs to inhibit TLR4 signaling pathway and reduce poststroke cerebral inflammation, providing acute neuroprotection and enhanced neurological recovery.

STEM CELLS TRANSLATIONAL MEDICINE (2021)

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Review Biotechnology & Applied Microbiology

Production and Quality Requirements of Human Platelet Lysate: A Position Statement from the Working Party on Cellular Therapies of the International Society of Blood Transfusion

Katharina Schallmoser et al.

TRENDS IN BIOTECHNOLOGY (2020)

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Review Biochemical Research Methods

Generation, purification and engineering of extracellular vesicles and their biomedical applications

Jin Gao et al.

METHODS (2020)

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Article Cell Biology

Quality and efficiency assessment of six extracellular vesicle isolation methods by nano-flow cytometry

Ye Tian et al.

JOURNAL OF EXTRACELLULAR VESICLES (2020)

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Article Endocrinology & Metabolism

Exosomes Secreted by Young Mesenchymal Stem Cells Promote New Bone Formation During Distraction Osteogenesis in Older Rats

Yachao Jia et al.

CALCIFIED TISSUE INTERNATIONAL (2020)

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Article Endocrinology & Metabolism

Melatonin-stimulated exosomes enhance the regenerative potential of chronic kidney disease-derived mesenchymal stem/stromal cells via cellular prion proteins

Yeo Min Yoon et al.

JOURNAL OF PINEAL RESEARCH (2020)

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Review Multidisciplinary Sciences

The biology, function, and biomedical applications of exosomes

Raghu Kalluri et al.

SCIENCE (2020)

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Article Multidisciplinary Sciences

Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis

Phuong-Uyen C. Dinh et al.

NATURE COMMUNICATIONS (2020)

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Article Chemistry, Analytical

Evaluation of exosome separation from human serum by frit-inlet asymmetrical flow field-flow fractionation and multiangle light scattering

Young Beom Kim et al.

ANALYTICA CHIMICA ACTA (2020)

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Article Cell & Tissue Engineering

Nanofiltration of growth media supplemented with human platelet lysates for pathogen-safe xeno-free expansion of mesenchymal stromal cells

Lassina Barro et al.

CYTOTHERAPY (2020)

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Article Genetics & Heredity

Extracellular Vesicles Derived from Human Gingival Mesenchymal Stem Cells: A Transcriptomic Analysis

Serena Silvestro et al.

GENES (2020)

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Article Cell & Tissue Engineering

Inflammatory priming enhances mesenchymal stromal cell secretome potential as a clinical product for regenerative medicine approaches through secreted factors and EV-miRNAs: the example of joint disease

Enrico Ragni et al.

STEM CELL RESEARCH & THERAPY (2020)

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Article Chemistry, Multidisciplinary

Transplantation of Human Mesenchymal Stem-Cell-Derived Exosomes Immobilized in an Adhesive Hydrogel for Effective Treatment of Spinal Cord Injury

Liming Li et al.

NANO LETTERS (2020)

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Article Engineering, Biomedical

Exosome laden oxygen releasing antioxidant and antibacterial cryogel wound dressing OxOBand alleviate diabetic and infectious wound healing

Parvaiz A. Shiekh et al.

BIOMATERIALS (2020)

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Article Multidisciplinary Sciences

Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling

Shiqi Hu et al.

SCIENCE ADVANCES (2020)

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Review Genetics & Heredity

Gene regulatory programmes of tissue regeneration

Joseph A. Goldman et al.

NATURE REVIEWS GENETICS (2020)

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Article Cell & Tissue Engineering

Epidermal stem cell-derived exosomes promote skin regeneration by downregulating transforming growth factor-β1 in wound healing

Mengna Duan et al.

STEM CELL RESEARCH & THERAPY (2020)

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News Item Multidisciplinary Sciences

COVID-19 Public needs to prep for vaccine side effects

Meredith Wadman

SCIENCE (2020)

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Article Engineering, Biomedical

Chitosan hydrogel incorporated with dental pulp stem cell-derived exosomes alleviates periodontitis in mice via a macrophage-dependent mechanism

Zongshan Shen et al.

BIOACTIVE MATERIALS (2020)

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Article Biology

Co-delivery of resolvin D1 and antibiotics with nanovesicles to lungs resolves inflammation and clears bacteria in mice

Jin Gao et al.

COMMUNICATIONS BIOLOGY (2020)

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Article Engineering, Biomedical

Treatment of infarcted heart tissue via the capture and local delivery of circulating exosomes through antibody-conjugated magnetic nanoparticles

Shiyu Liu et al.

NATURE BIOMEDICAL ENGINEERING (2020)

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Article Materials Science, Biomaterials

Bead-Based Extracellular Vesicle Analysis Using Flow Cytometry

Katherine S. Yang et al.

ADVANCED BIOSYSTEMS (2020)

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Article Materials Science, Multidisciplinary

Calming Cytokine Storm in Pneumonia by Targeted Delivery of TPCA-1 Using Platelet-Derived Extracellular Vesicles

Qingle Ma et al.

MATTER (2020)

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Article Nanoscience & Nanotechnology

Quantum Dot Labeling and Visualization of Extracellular Vesicles

Mengying Zhang et al.

ACS APPLIED NANO MATERIALS (2020)

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Article Cell Biology

miR-23a-3p-abundant small extracellular vesicles released from Gelma/nanoclay hydrogel for cartilage regeneration

Hongxing Hu et al.

JOURNAL OF EXTRACELLULAR VESICLES (2020)

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Review Medicine, Research & Experimental

Progress, opportunity, and perspective on exosome isolation - efforts for efficient exosome-based theranostics

Dongbin Yang et al.

THERANOSTICS (2020)

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Article Medicine, Research & Experimental

Tumor cell-derived exosomes home to their cells of origin and can be used as Trojan horses to deliver cancer drugs

Li Qiao et al.

THERANOSTICS (2020)

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Article Biochemical Research Methods

Asymmetric-flow field-flow fractionation technology for exomere and small extracellular vesicle separation and characterization

Haiying Zhang et al.

NATURE PROTOCOLS (2019)

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Article Cell & Tissue Engineering

The skin regeneration potential of a pro-angiogenic secretome from human skin-derived multipotent stromal cells

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JOURNAL OF TISSUE ENGINEERING (2019)

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Article Engineering, Biomedical

MSC exosomes alleviate temporomandibular joint osteoarthritis by attenuating inflammation and restoring matrix homeostasis

Shipin Zhang et al.

BIOMATERIALS (2019)

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Review Clinical Neurology

Stroke in China: advances and challenges in epidemiology, prevention, and management

Simiao Wu et al.

LANCET NEUROLOGY (2019)

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Article Engineering, Biomedical

Photosensitive Hydrogel Creates Favorable Biologic Niches to Promote Spinal Cord Injury Repair

Zhengwei Cai et al.

ADVANCED HEALTHCARE MATERIALS (2019)

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Article Engineering, Biomedical

TPP1 Delivery to Lysosomes with Extracellular Vesicles and their Enhanced Brain Distribution in the Animal Model of Batten Disease

Matthew J. Haney et al.

ADVANCED HEALTHCARE MATERIALS (2019)

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Review Pharmacology & Pharmacy

Enabling biodegradable functional biomaterials for the management of neurological disorders

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ADVANCED DRUG DELIVERY REVIEWS (2019)

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Article Engineering, Biomedical

MSC-derived sEVs enhance patency and inhibit calcification of synthetic vascular grafts by immunomodulation in a rat model of hyperlipidemia

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BIOMATERIALS (2019)

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Article Chemistry, Physical

Precise Construction of Cell-Instructive 3D Microenvironments by Photopatterning a Biodegradable Hydrogel

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CHEMISTRY OF MATERIALS (2019)

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Article Materials Science, Biomaterials

Delivery of miR-675 by stem cell-derived exosomes encapsulated in silk fibroin hydrogel prevents aging-induced vascular dysfunction in mouse hindlimb

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MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

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Article Multidisciplinary Sciences

Exosomes Engineered to Express a Cardiomyocyte Binding Peptide Demonstrate Improved Cardiac Retention in Vivo

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SCIENTIFIC REPORTS (2019)

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Article Engineering, Biomedical

Hyaluronic Acid Hydrogel Integrated with Mesenchymal Stem Cell-Secretome to Treat Endometrial Injury in a Rat Model of Asherman's Syndrome

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ADVANCED HEALTHCARE MATERIALS (2019)

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Article Chemistry, Multidisciplinary

Mapping Subpopulations of Cancer Cell-Derived Extracellular Vesicles and Particles by Nano-Flow Cytometry

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ACS NANO (2019)

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Efficient Angiogenesis-Based Diabetic Wound Healing/Skin Reconstruction through Bioactive Antibacterial Adhesive Ultraviolet Shielding Nanodressing with Exosome Release

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ACS NANO (2019)

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Article Chemistry, Multidisciplinary

Intranasal Delivery of Mesenchymal Stem Cell Derived Exosomes Loaded with Phosphatase and Tensin Homolog siRNA Repairs Complete Spinal Cord Injury

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Article Chemistry, Multidisciplinary

Needle-Free Injection of Exosomes Derived from Human Dermal Fibroblast Spheroids Ameliorates Skin Photoaging

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Article Cell Biology

Exosomes derived from miR-375-overexpressing human adipose mesenchymal stem cells promote bone regeneration

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CELL PROLIFERATION (2019)

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Article Cell Biology

Exosomes derived from pro-inflammatory bone marrow-derived mesenchymal stem cells reduce inflammation and myocardial injury via mediating macrophage polarization

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JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

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Review Neurosciences

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PROGRESS IN NEUROBIOLOGY (2019)

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Adipose Mesenchymal Extracellular Vesicles as Alpha-1-Antitrypsin Physiological Delivery Systems for Lung Regeneration

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CELLS (2019)

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Systematic characterization of extracellular vesicles sorting domains and quantification at the single molecule - single vesicle level by fluorescence correlation spectroscopy and single particle imaging

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JOURNAL OF EXTRACELLULAR VESICLES (2019)

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Serum-free media supplements carry miRNAs that co-purify with extracellular vesicles

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Journal of Extracellular Vesicles (2019)

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Mesenchymal stem cell-derived exosomes ameliorate intervertebral disc degeneration via anti-oxidant and anti-inflammatory effects

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FREE RADICAL BIOLOGY AND MEDICINE (2019)

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INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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NATURE REVIEWS NEUROLOGY (2019)

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Exosome-integrated titanium oxide nanotubes for targeted bone regeneration

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ACTA BIOMATERIALIA (2019)

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Euryale Ferox Seed-Inspired Superlubricated Nanoparticles for Treatment of Osteoarthritis

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Article Multidisciplinary Sciences

Platelet-derived-Extracellular Vesicles Promote Hemostasis and Prevent the Development of Hemorrhagic Shock

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SCIENTIFIC REPORTS (2019)

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Review Cell & Tissue Engineering

Functional proteins of mesenchymal stem cell-derived extracellular vesicles

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STEM CELL RESEARCH & THERAPY (2019)

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Extracellular vesicles and coagulation in blood from healthy humans revisited

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JOURNAL OF EXTRACELLULAR VESICLES (2019)

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Exosomes from human umbilical cord mesenchymal stem cells enhance fracture healing through HIF-1α-mediated promotion of angiogenesis in a rat model of stabilized fracture

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CELL PROLIFERATION (2019)

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Development of DNA-anchored assembly of small extracellular vesicle for efficient antigen delivery to antigen presenting cells

Akihiro Matsumoto et al.

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Review Biotechnology & Applied Microbiology

Extracellular Microvesicles as New Industrial Therapeutic Frontiers

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TRENDS IN BIOTECHNOLOGY (2019)

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Corneal Wound Healing Effects of Mesenchymal Stem Cell Secretome Delivered Within a Viscoelastic Gel Carrier

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STEM CELLS TRANSLATIONAL MEDICINE (2019)

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Human umbilical cord mesenchymal stem cell derived exosomes encapsulated in functional peptide hydrogels promote cardiac repair

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BIOMATERIALS SCIENCE (2019)

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Incorporation of small extracellular vesicles in sodium alginate hydrogel as a novel therapeutic strategy for myocardial infarction

Kaiqi Lv et al.

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Extracellular vesicles expressing a single-chain variable fragment of an HIV-1 specific antibody selectively target Env+ tissues

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THERANOSTICS (2019)

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Optimisation of imaging flow cytometry for the analysis of single extracellular vesicles by using fluorescence-tagged vesicles as biological reference material

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JOURNAL OF EXTRACELLULAR VESICLES (2019)

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Article Medicine, Research & Experimental

M2 microglia-derived exosomes protect the mouse brain from ischemia-reperfusion injury via exosomal miR-124

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THERANOSTICS (2019)

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Employing Macrophage-Derived Microvesicle for Kidney-Targeted Delivery of Dexamethasone: An Efficient Therapeutic Strategy against Renal Inflammation and Fibrosis

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Article Medicine, Research & Experimental

Engineering Bioactive Self-Healing Antibacterial Exosomes Hydrogel for Promoting Chronic Diabetic Wound Healing and Complete Skin Regeneration

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Exosomes from mesenchymal stem cells modulate endoplasmic reticulum stress to protect against nucleus pulposus cell death and ameliorate intervertebral disc degeneration in vivo

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Article Cell & Tissue Engineering

Inflammation-Stimulated Mesenchymal Stromal Cell-Derived Extracellular Vesicles Attenuate Inflammation

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Tissue-Engineered Bone Immobilized with Human Adipose Stem Cells-Derived Exosomes Promotes Bone Regeneration

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ACS APPLIED MATERIALS & INTERFACES (2018)

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Modification of Extracellular Vesicles by Fusion with Liposomes for the Design of Personalized Biogenic Drug Delivery Systems

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Stem cell-inspired secretome-rich injectable hydrogel to repair injured cardiac tissue

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ACTA BIOMATERIALIA (2018)

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Strategic design of extracellular vesicle drug delivery systems

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Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy

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Article Biochemistry & Molecular Biology

Biofunctionalized Scaffold in Bone Tissue Repair

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Review Neurosciences

Intrinsic mechanisms of neuronal axon regeneration

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NATURE REVIEWS NEUROSCIENCE (2018)

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Review Physiology

THE BIOLOGY OF REGENERATION FAILURE AND SUCCESS AFTER SPINAL CORD INJURY

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PHYSIOLOGICAL REVIEWS (2018)

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Anchor peptide captures, targets, and loads exosomes of diverse origins for diagnostics and therapy

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SCIENCE TRANSLATIONAL MEDICINE (2018)

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Article Cell & Tissue Engineering

Exosomes Derived from Hypoxia-Treated Human Adipose Mesenchymal Stem Cells Enhance Angiogenesis Through the PKA Signaling Pathway

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STEM CELLS AND DEVELOPMENT (2018)

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Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson's disease treatment

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NATURE COMMUNICATIONS (2018)

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The microRNA regulatory landscape of MSC-derived exosomes: a systems view

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SCIENTIFIC REPORTS (2018)

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Mesenchymal stem cells-derived exosomes are more immunosuppressive than microparticles in inflammatory arthritis

Stella Cosenza et al.

THERANOSTICS (2018)

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Review Immunology

Extracellular Vesicle: An Emerging Mediator of Intracellular Crosstalk in Lung Inflammation and Injury

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FRONTIERS IN IMMUNOLOGY (2018)

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Article Nanoscience & Nanotechnology

Enhanced Therapeutic Effects of Mesenchymal Stem Cell-Derived Exosomes with an Injectable Hydrogel for Hindlimb Ischemia Treatment

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ACS APPLIED MATERIALS & INTERFACES (2018)

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Article Chemistry, Multidisciplinary

Recombinant phosphatidylserine-binding nanobodies for targeting of extracellular vesicles to tumor cells: a plug-and-play approach

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NANOSCALE (2018)

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Pro inflammatory stimuli enhance the immunosuppressive functions of adipose mesenchymal stem cells derived exosomes

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SCIENTIFIC REPORTS (2018)

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Article Chemistry, Analytical

Exosome Isolation: Cyclical Electrical Field Flow Fractionation in Low-Ionic-Strength Fluids

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ANALYTICAL CHEMISTRY (2018)

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Article Chemistry, Multidisciplinary

Reprogramming Exosomes as Nanoscale Controllers of Cellular Immunity

Qnqin Cheng et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

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Review Cell Biology

Therapeutic biomaterials based on extracellular vesicles: classification of bio-engineering and mimetic preparation routes

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JOURNAL OF EXTRACELLULAR VESICLES (2018)

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Article Cell & Tissue Engineering

Chitosan Wound Dressings Incorporating Exosomes Derived from MicroRNA-126-Overexpressing Synovium Mesenchymal Stem Cells Provide Sustained Release of Exosomes and Heal Full-Thickness Skin Defects in a Diabetic Rat Model

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STEM CELLS TRANSLATIONAL MEDICINE (2017)

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Article Cell & Tissue Engineering

Exosomes Derived From Akt-Modified Human Umbilical Cord Mesenchymal Stem Cells Improve Cardiac Regeneration and Promote Angiogenesis via Activating Platelet-Derived Growth Factor D

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STEM CELLS TRANSLATIONAL MEDICINE (2017)

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Article Cell Biology

MiR-122 modification enhances the therapeutic efficacy of adipose tissue-derived mesenchymal stem cells against liver fibrosis

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JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2017)

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Article Cell Biology

Exosomes derived from miR-181-5p-modified adipose-derived mesenchymal stem cells prevent liver fibrosis via autophagy activation

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JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2017)

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Extracellular vesicles from mesenchymal stem cells activates VEGF receptors and accelerates recovery of hindlimb ischemia

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JOURNAL OF CONTROLLED RELEASE (2017)

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Article Biotechnology & Applied Microbiology

Functional Delivery of Lipid-Conjugated siRNA by Extracellular Vesicles

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MOLECULAR THERAPY (2017)

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Review Urology & Nephrology

Isolation and characterization of urinary extracellular vesicles: implications for biomarker discovery

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NATURE REVIEWS NEPHROLOGY (2017)

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Review Cell & Tissue Engineering

Concise Review: MSC-Derived Exosomes for Cell-Free Therapy

Donald G. Phinney et al.

STEM CELLS (2017)

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Article Cell & Tissue Engineering

Conditioned Medium from Periodontal Ligament Stem Cells Enhances Periodontal Regeneration

Mizuki Nagata et al.

TISSUE ENGINEERING PART A (2017)

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Review Cell & Tissue Engineering

Biomaterials and Bioactive Agents in Spinal Fusion

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TISSUE ENGINEERING PART B-REVIEWS (2017)

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3,3′-Diindolylmethane stimulates exosomal Wnt11 autocrine signaling in human umbilical cord mesenchymal stem cells to enhance wound healing

Hui Shi et al.

THERANOSTICS (2017)

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Article Medicine, Research & Experimental

Exosomes derived from platelet-rich plasma promote the re-epithelization of chronic cutaneous wounds via activation of YAP in a diabetic rat model

Shang-Chun Guo et al.

THERANOSTICS (2017)

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Article Medicine, Research & Experimental

Interleukin 3-receptor targeted exosomes inhibit in vitro and in vivo Chronic Myelogenous Leukemia cell growth

Daniele Bellavia et al.

THERANOSTICS (2017)

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Article Biotechnology & Applied Microbiology

MiRNA-Sequence Indicates That Mesenchymal Stem Cells and Exosomes Have Similar Mechanism to Enhance Cardiac Repair

Lianbo Shao et al.

BIOMED RESEARCH INTERNATIONAL (2017)

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Article Physiology

GMSC-Derived Exosomes Combined with a Chitosan/Silk Hydrogel Sponge Accelerates Wound Healing in a Diabetic Rat Skin Defect Model

Quan Shi et al.

FRONTIERS IN PHYSIOLOGY (2017)

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Article Engineering, Biomedical

Tailor-made purified human platelet lysate concentrated in neurotrophins for treatment of Parkinson's disease

Ming-Li Chou et al.

BIOMATERIALS (2017)

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Article Engineering, Biomedical

Augmented liver targeting of exosomes by surface modification with cationized pullulan

Ryo Tamura et al.

ACTA BIOMATERIALIA (2017)

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Article Cardiac & Cardiovascular Systems

Fabrication of Synthetic Mesenchymal Stem Cells for the Treatment of Acute Myocardial Infarction in Mice

Lan Luo et al.

CIRCULATION RESEARCH (2017)

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Article Cell Biology

TRAIL delivery by MSC-derived extracellular vesicles is an effective anticancer therapy

ZhengQiang Yuan et al.

JOURNAL OF EXTRACELLULAR VESICLES (2017)

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The Exosome - A Naturally Secreted Nanoparticle and its Application to Wound Healing

Sweta Rani et al.

ADVANCED MATERIALS (2016)

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Article Nanoscience & Nanotechnology

Cellular Engineering with Membrane Fusogenic Liposomes to Produce Functionalized Extracellular Vesicles

Junsung Lee et al.

ACS APPLIED MATERIALS & INTERFACES (2016)

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Article Cardiac & Cardiovascular Systems

Exosomes induce and reverse monocrotaline-induced pulmonary hypertension in mice

Jason M. Aliotta et al.

CARDIOVASCULAR RESEARCH (2016)

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Article Cell & Tissue Engineering

Oncogene Knockdown via Active Loading of Small RNAs into Extracellular Vesicles by Sonication

Tek N. Lamichhane et al.

CELLULAR AND MOLECULAR BIOENGINEERING (2016)

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Article Biochemistry & Molecular Biology

Exosomes Secreted by Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Repair Critical-Sized Bone Defects through Enhanced Angiogenesis and Osteogenesis in Osteoporotic Rats

Xin Qi et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2016)

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Article Chemistry, Multidisciplinary

Cell membrane-formed nanovesicles for disease-targeted delivery

Jin Gao et al.

JOURNAL OF CONTROLLED RELEASE (2016)

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Article Chemistry, Multidisciplinary

Comparing exosome-like vesicles with liposomes for the functional cellular delivery of small RNAs

Stephan Stremersch et al.

JOURNAL OF CONTROLLED RELEASE (2016)

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Article Chemistry, Multidisciplinary

PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time

S. A. A. Kooijmans et al.

JOURNAL OF CONTROLLED RELEASE (2016)

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Article Pediatrics

Exosomes secreted from bone marrow-derived mesenchymal stem cells protect the intestines from experimental necrotizing enterocolitis

Terrence M. Rager et al.

JOURNAL OF PEDIATRIC SURGERY (2016)

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Article Biotechnology & Applied Microbiology

Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing

Marie-Cecile Didiot et al.

MOLECULAR THERAPY (2016)

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Article Biotechnology & Applied Microbiology

Mesenchymal Stem Cells Deliver Exogenous MicroRNA-let7c via Exosomes to Attenuate Renal Fibrosis

Bo Wang et al.

MOLECULAR THERAPY (2016)

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Article Nanoscience & Nanotechnology

Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

Myung Soo Kim et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2016)

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Article Chemistry, Multidisciplinary

Stem cell secretome-rich nanoclay hydrogel: a dual action therapy for cardiovascular regeneration

Renae Waters et al.

NANOSCALE (2016)

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Article Biotechnology & Applied Microbiology

A 3D bioprinting system to produce human-scale tissue constructs with structural integrity

Hyun-Wook Kang et al.

NATURE BIOTECHNOLOGY (2016)

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Article Multidisciplinary Sciences

Biophysical insight into mechanisms of sonoporation

Brandon Helfield et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Article Cell & Tissue Engineering

HucMSC Exosome-Delivered 14-3-3 Orchestrates Self-Control of the Wnt Response via Modulation of YAP During Cutaneous Regeneration

Bin Zhang et al.

STEM CELLS (2016)

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Article Multidisciplinary Sciences

Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein-protein interaction module

Nambin Yim et al.

NATURE COMMUNICATIONS (2016)

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Article Cell & Tissue Engineering

Exosomes/tricalcium phosphate combination scaffolds can enhance bone regeneration by activating the PI3K/Akt signaling pathway

Jieyuan Zhang et al.

STEM CELL RESEARCH & THERAPY (2016)

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Article Cell Biology

The RNA-Binding Protein SYNCRIP Is a Component of the Hepatocyte Exosomal Machinery Controlling MicroRNA Sorting

Laura Santangelo et al.

CELL REPORTS (2016)

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Article Cell & Tissue Engineering

Umbilical Cord-Derived Mesenchymal Stem Cell-Derived Exosomal MicroRNAs Suppress Myofibroblast Differentiation by Inhibiting the Transforming Growth Factor-β/SMAD2 Pathway During Wound Healing

Shuo Fang et al.

STEM CELLS TRANSLATIONAL MEDICINE (2016)

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Article Cell Biology

Display of GPI-anchored anti-EGFR nanobodies on extracellular vesicles promotes tumour cell targeting

Sander A. A. Kooijmans et al.

JOURNAL OF EXTRACELLULAR VESICLES (2016)

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Review Cell Biology

Stem Cell-Derived Extracellular Vesicles and Immune-Modulation

Jacopo Burrello et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2016)

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Article Critical Care Medicine

Therapeutic Effects of Human Mesenchymal Stem Cell-derived Microvesicles in Severe Pneumonia in Mice

Antoine Monsel et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2015)

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Article Surgery

Microvesicles Derived From Human Mesenchymal Stem Cells Restore Alveolar Fluid Clearance in Human Lungs Rejected for Transplantation

S. Gennai et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2015)

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Article Medicine, General & Internal

Platelet Transfusion: A Clinical Practice Guideline From the AABB

Richard M. Kaufman et al.

ANNALS OF INTERNAL MEDICINE (2015)

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Article Cell & Tissue Engineering

Secretomes from bone marrow-derived mesenchymal stromal cells enhance periodontal tissue regeneration

Takamasa Kawai et al.

CYTOTHERAPY (2015)

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Article Biochemistry & Molecular Biology

Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration

Yoshihiro Nakamura et al.

FEBS LETTERS (2015)

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Article Dentistry, Oral Surgery & Medicine

An Experimental Study on Guided Bone Regeneration Using a Polylactide-co-glycolide Membrane-Immobilized Conditioned Medium

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INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS (2015)

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Article Biochemistry & Molecular Biology

Stabilization of Exosome-targeting Peptides via Engineered Glycosylation

Michelle E. Hung et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

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Article Medicine, Research & Experimental

Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair

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JOURNAL OF CLINICAL INVESTIGATION (2015)

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Article Chemistry, Multidisciplinary

Exosomes as drug delivery vehicles for Parkinson's disease therapy

Matthew J. Haney et al.

JOURNAL OF CONTROLLED RELEASE (2015)

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Active loading into extracellular vesicles significantly improves the cellular uptake and photodynamic effect of porphyrins

Gregor Fuhrmann et al.

JOURNAL OF CONTROLLED RELEASE (2015)

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Article Medicine, Research & Experimental

Exosomes released from human induced pluripotent stem cells-derived MSCs facilitate cutaneous wound healing by promoting collagen synthesis and angiogenesis

Jieyuan Zhang et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2015)

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Editorial Material Multidisciplinary Sciences

PERSPECTIVE Special delivery for the gut

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NATURE (2015)

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Article Multidisciplinary Sciences

Nanoparticle biointerfacing by platelet membrane cloaking

Che-Ming J. Hu et al.

NATURE (2015)

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Article Multidisciplinary Sciences

Glucose Starvation in Cardiomyocytes Enhances Exosome Secretion and Promotes Angiogenesis in Endothelial Cells

Nahuel A. Garcia et al.

PLOS ONE (2015)

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Article Cell Biology

Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis

Sarah E. Headland et al.

SCIENCE TRANSLATIONAL MEDICINE (2015)

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Article Cell & Tissue Engineering

HucMSC-Exosome Mediated-Wnt4 Signaling Is Required for Cutaneous Wound Healing

Bin Zhang et al.

STEM CELLS (2015)

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Article Cell & Tissue Engineering

Mesenchymal Stem Cell Exosomes Induce Proliferation and Migration of Normal and Chronic Wound Fibroblasts, and Enhance Angiogenesis In Vitro

Arsalan Shabbir et al.

STEM CELLS AND DEVELOPMENT (2015)

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Article Cell & Tissue Engineering

Exosomes secreted by human-induced pluripotent stem cell-derived mesenchymal stem cells attenuate limb ischemia by promoting angiogenesis in mice

Guo-wen Hu et al.

STEM CELL RESEARCH & THERAPY (2015)

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Article Cell Biology

Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting

Oscar P. B. Wiklander et al.

JOURNAL OF EXTRACELLULAR VESICLES (2015)

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Article Biochemical Research Methods

Surface Functionalization of Exosomes Using Click Chemistry

Tyson Smyth et al.

BIOCONJUGATE CHEMISTRY (2014)

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Review Hematology

Platelet microparticles: Detection and assessment of their paradoxical functional roles in disease and regenerative medicine

Thierry Burnouf et al.

BLOOD REVIEWS (2014)

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Review Biochemistry & Molecular Biology

Exosomes Derived from Mesenchymal Stem Cells

Bo Yu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2014)

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Article Biochemistry & Molecular Biology

Therapeutic Use of Stem Cell Transplantation for Cell Replacement or Cytoprotective Effect of Microvesicle Released from Mesenchymal Stem Cell

Moonhwan Choi et al.

MOLECULES AND CELLS (2014)

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Article Clinical Neurology

Systemic Exosomal siRNA Delivery Reduced Alpha-Synuclein Aggregates in Brains of Transgenic Mice

J. Mark Cooper et al.

MOVEMENT DISORDERS (2014)

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Article Nanoscience & Nanotechnology

Exosome-mediated delivery of functionally active miRNA-155 inhibitor to macrophages

Fatemeh Momen-Heravi et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2014)

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Article Chemistry, Physical

Enhanced lubrication on tissue and biomaterial surfaces through peptide-mediated binding of hyaluronic acid

Anirudha Singh et al.

NATURE MATERIALS (2014)

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Article Multidisciplinary Sciences

Quantitative and stoichiometric analysis of the microRNA content of exosomes

John R. Chevillet et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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Article Cell & Tissue Engineering

Human Mesenchymal Stem Cell Microvesicles for Treatment of Escherichia coli Endotoxin- Induced Acute Lung Injury in Mice

Ying-gang Zhu et al.

STEM CELLS (2014)

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Article Cell & Tissue Engineering

Mesenchymal Stem Cells Secrete Immunologically Active Exosomes

Bin Zhang et al.

STEM CELLS AND DEVELOPMENT (2014)

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Article Cell & Tissue Engineering

Mesenchymal stem cell-derived exosomes promote hepatic regeneration in drug-induced liver injury models

Cheau Yih Tan et al.

STEM CELL RESEARCH & THERAPY (2014)

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Article Immunology

Immunomodulatory potential of human adipose mesenchymal stem cells derived exosomes on in vitro stimulated T cells

Rebeca Blazquez et al.

FRONTIERS IN IMMUNOLOGY (2014)

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Review Immunology

Regulation of immune responses by extracellular vesicles

Paul D. Robbins et al.

NATURE REVIEWS IMMUNOLOGY (2014)

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Article Chemistry, Multidisciplinary

Magnetic and Photoresponsive Theranosomes: Translating Cell-Released Vesicles into Smart Nanovectors for Cancer Therapy

Amanda K. A. Silva et al.

ACS NANO (2013)

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Article Biochemistry & Molecular Biology

Novel application of stem cell-derived factors for periodontal regeneration

Takeharu Inukai et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)

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Article Dentistry, Oral Surgery & Medicine

Novel Cell-Free Regeneration of Bone Using Stem Cell-Derived Growth Factors

Wataru Katagiri et al.

INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS (2013)

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Article Endocrinology & Metabolism

Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats

Hongqi Xin et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2013)

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Article Chemistry, Multidisciplinary

Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into extracellular vesicles

Sander A. A. Kooijmans et al.

JOURNAL OF CONTROLLED RELEASE (2013)

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Article Biotechnology & Applied Microbiology

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

Shin-ichiro Ohno et al.

MOLECULAR THERAPY (2013)

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Article Multidisciplinary Sciences

Exosomal Signaling during Hypoxia Mediates Microvascular Endothelial Cell Migration and Vasculogenesis

Carlos Salomon et al.

PLOS ONE (2013)

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Article Multidisciplinary Sciences

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

Carolina Villarroya-Beltri et al.

NATURE COMMUNICATIONS (2013)

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Article Cell Biology

How pure are your vesicles?

Jason Webber et al.

JOURNAL OF EXTRACELLULAR VESICLES (2013)

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Article Cardiac & Cardiovascular Systems

Exosomes Mediate the Cytoprotective Action of Mesenchymal Stromal Cells on Hypoxia-Induced Pulmonary Hypertension

Changjin Lee et al.

CIRCULATION (2012)

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Article Clinical Neurology

Platelet Microparticles Induce Angiogenesis and Neurogenesis after Cerebral Ischemia

Yael Hayon et al.

CURRENT NEUROVASCULAR RESEARCH (2012)

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Article Biophysics

Microbubble-induced sonoporation involved in ultrasound-mediated DNA transfection in vitro at low acoustic pressures

Yuanyuan Qiu et al.

JOURNAL OF BIOMECHANICS (2012)

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Article Biochemistry & Molecular Biology

Platelet Microparticles Promote Neural Stem Cell Proliferation, Survival and Differentiation

Yael Hayon et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2012)

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Article Biochemical Research Methods

Proteomic Analysis of Microvesicles Derived from Human Mesenchymal Stem Cells

Han-Soo Kim et al.

JOURNAL OF PROTEOME RESEARCH (2012)

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Article Cell & Tissue Engineering

Conditioned Media from Mesenchymal Stem Cells Enhanced Bone Regeneration in Rat Calvarial Bone Defects

Masashi Osugi et al.

TISSUE ENGINEERING PART A (2012)

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Article Multidisciplinary Sciences

Delivery of chemotherapeutic drugs in tumour cell-derived microparticles

Ke Tang et al.

NATURE COMMUNICATIONS (2012)

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Article Biotechnology & Applied Microbiology

Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain

Xiaoying Zhuang et al.

MOLECULAR THERAPY (2011)

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Article Biotechnology & Applied Microbiology

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

Lydia Alvarez-Erviti et al.

NATURE BIOTECHNOLOGY (2011)

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Review Biotechnology & Applied Microbiology

Bio-inspired, bioengineered and biomimetic drug delivery carriers

Jin-Wook Yoo et al.

NATURE REVIEWS DRUG DISCOVERY (2011)

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Article Biotechnology & Applied Microbiology

A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

Dongmei Sun et al.

MOLECULAR THERAPY (2010)

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Article Cell Biology

Profile of Exosomes Related Proteins Released by Differentiated and Undifferentiated Human Keratinocytes

Claudia Chavez-Munoz et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2009)

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Article Oncology

Targeting tumor antigens to secreted membrane vesicles in vivo induces efficient antitumor immune responses

Ingrid S. Zeelenberg et al.

CANCER RESEARCH (2008)

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Article Biochemical Research Methods

Platelet microparticles are heterogeneous and highly dependent on the activation mechanism: Studies using a new digital flow cytometer

Silvia Perez-Pujol et al.

CYTOMETRY PART A (2007)

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Article Hematology

Accumulation of MFG-E8/lactadherin on exosomes from immature dendritic cells

P Véron et al.

BLOOD CELLS MOLECULES AND DISEASES (2005)

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Article Cell Biology

Platelet-derived microvesicles transfer tissue factor to monocytes but not to neutrophils

W Lösche et al.

PLATELETS (2004)

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Article Hematology

Platelet microparticles induce angiogenesis in vitro

HK Kim et al.

BRITISH JOURNAL OF HAEMATOLOGY (2004)

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Article Immunology

Antigen-presenting cell exosomes are protected from complement-mediated lysis by expression of CD55 and CD59

A Clayton et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2003)

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