期刊
BIOACTIVE MATERIALS
卷 13, 期 -, 页码 212-222出版社
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2021.10.043
关键词
Bacterial cellulose; Quaternized chitosan; Multifunctional dressing; Antibacterial activity; Healing promotion
资金
- National Natural Science Foundation of China [31760265, 82160355]
- Natural Science Foundation of Jiangxi Province [20171ACB21036, 20192ACB80008]
A multifunctional dressing consisting of collagen I and an antibacterial agent has been developed to treat and promote the healing of infected wounds. The dressing showed excellent antibacterial properties and cell compatibility, and significantly improved water retention compared to existing options.
The treatment and healing of infected skin lesions is one of the major challenges in surgery. To solve this problem, collagen I (Col-I) and the antibacterial agent hydroxypropyltrimethyl ammonium chloride chitosan (HACC) were composited into the bacterial cellulose (BC) three-dimensional network structure by a novel membrane-liquid interface (MLI) culture, and a Col-I/HACC/BC (CHBC) multifunctional dressing was designed. The water absorption rate and water vapor transmission rate of the obtained CHBC dressing were 35.78 +/- 2.45 g/g and 3084 +/- 56 g m(-2).day(-1), respectively. The water retention of the CHBC dressing was significantly improved compared with the BC caused by the introduced Col-I and HACC. In vitro results indicated that the combined advantages of HACC and Col-I confer on CHBC dressings not only have outstanding antibacterial properties against Staphylococcus aureus (S. aureus) compared with BC and CBC, but also exhibit better cyto-compatibility than BC and HBC to promote the proliferation and spread of NIH3T3 cells and HUVECs. Most importantly, the results of in vivo animal tests demonstrated that the CHBC dressings fully promoted wound healing for 8 days and exhibited shorter healing times, especially in the case of wound infection. Excellent skin regeneration effects and higher expression levels of collagen during infection were also shown in the CHBC group. We believe that CHBC composites with favorable multifunctionality have potential applications as wound dressings to treat infected wounds.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据