Expression of tumour transcription factor GLI1 in canine mammary tumours tissue

Article Veterinary Sciences

Clinical outcome of dogs diagnosed with canine inflammatory mammary cancer treated with metronomic cyclophosphamide, a cyclooxygenase-2 inhibitor and toceranib phosphate

Daniel Alonso-Miguel et al.

Summary: Canine inflammatory mammary cancer (IMC) is a highly malignant and invasive cancer with challenges in effective treatment. This study compared the efficacy of a multi-drug therapy (MT) involving an oral COX-2 inhibitor, toceranib phosphate, and oral cyclophosphamide with single-drug therapy (ST) in dogs with secondary IMC, finding that MT resulted in significantly higher overall survival time, disease-free survival, and time to progression. Adverse events were more frequent in MT patients but were mostly mild to moderate and resolved with supportive care, indicating the potential therapeutic efficacy of the MT protocol for dogs with IMC.

VETERINARY AND COMPARATIVE ONCOLOGY (2022)

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Article Anatomy & Morphology

Heat shock protein 60 expression and localisation in different tissues and testis development of male cattle (cattle-yak and yak)

S. Zou et al.

Summary: The study investigated the expression and localization of Hsp60 gene in testicular development of cattle-yak and yak. Results showed variations in Hsp60 expression among different tissues and developmental stages, with significantly higher expression in cattle-yak than yak. Hsp60 proteins were found to be located in epithelial cells, spermatocytes, sperm cells, and mesenchymal cells.

FOLIA MORPHOLOGICA (2021)

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Article Oncology

Targeting the Sonic Hedgehog Pathway to Suppress the Expression of the Cancer Stem Cell (CSC)-Related Transcription Factors and CSC-Driven Thyroid Tumor Growth

Yurong Lu et al.

Summary: The Sonic Hedgehog (Shh) pathway plays a crucial role in regulating thyroid cancer stem cell self-renewal, with inhibition of this pathway showing potential in preventing tumor initiation driven by thyroid cancer stem cells.

CANCERS (2021)

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Review Oncology

Cancer Stem Cells-Key Players in Tumor Relapse

Monica Marzagalli et al.

Summary: Cancer stem cells (CSCs) are a subset of cancer cells with tumor-initiating and self-renewal capacity, as well as high adaptive abilities, contributing to treatment failure and tumor progression/relapse. Understanding the molecular mechanisms associated with stemness-driven resistance is crucial for developing more effective drugs and durable responses. Explored mechanisms by CSCs to overcome different therapeutic strategies highlight their plasticity as an insidious trait responsible for their adaptation/escape, with novel CSC-specific approaches showing promising preclinical and clinical applications.

CANCERS (2021)

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Review Biochemistry & Molecular Biology