Delivery of doxorubicin by dual responsive carboxymethyl chitosan based nanogel and in vitro performance

Article Chemistry, Applied

Chitosan-based DDSs for pH/hypoxia dual-triggered DOX delivery: Facile morphology modulation for higher in vitro cytotoxicity

Pengwei Xie et al.

Summary: A pH/hypoxia dual-responsive nanowire was fabricated with higher drug loading capacity and better drug release performance, showing promising potential for tumor chemotherapy.

CARBOHYDRATE POLYMERS (2022)

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Article Chemistry, Applied

Facile synthesis of pH-responsive sodium alginate/carboxymethyl chitosan hydrogel beads promoted by hydrogen bond

Huijuan Jing et al.

Summary: In this study, a novel synthesis strategy utilizing hydrogen bonds was used to prepare sodium alginate/carboxymethyl chitosan hydrogel beads. The beads demonstrated excellent pH sensitivity, reversibility, and protein loading capacity, making them a potential carrier for oral delivery of proteins.

CARBOHYDRATE POLYMERS (2022)

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Article Chemistry, Multidisciplinary

Synthesis and characterization of curcumin-loaded pH/reduction dual-responsive folic acid modified carboxymethyl cellulose-based microcapsules for targeted drug delivery

Qingye Meng et al.

Summary: In this study, eco-friendly, biodegradable, and biocompatible carboxymethyl cellulose (CMC) was used to design folic acid modified pH and reduction dual-responsive microcapsules for targeted delivery and release of curcumin (CUR). The excess drug and solvent could be recycled, showing good biocompatibility and anti-tumor effects. This smart delivery system has the potential for clinical applications.

JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY (2022)

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Article Biochemistry & Molecular Biology

Delivery of curcumin by fucoidan-coated mesoporous silica nanoparticles: Fabrication, characterization, and in vitro release performance

Xu Zhang et al.

Summary: In this study, complex nanoparticles containing disulfide bonds (SS) were designed and prepared as curcumin (Cur) carriers. When the mass ratio of MSN to FUC was 2:1, the nanospheres particle size was the smallest. MSN-Cur-SS-FUC encapsulated curcumin with an encapsulation rate over 90% and showed a cumulative release rate over 80% in 24 hours.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Review Pharmacology & Pharmacy

Engineering a folic acid-decorated ultrasmall gemcitabine nanocarrier for breast cancer therapy: Dual targeting of tumor cells and tumor-associated macrophages

Pearl Moharil et al.

Summary: Combining passive targeting with active targeting is a promising approach to improve the therapeutic efficacy of nanotherapy. In this study, ultra-small-sized gemcitabine-based nanoparticles were combined with folic acid conjugation for enhanced dual targeted delivery to tumor cells and tumor-associated macrophages. The co-delivery system showed small particle size and achieved significant reduction of tumor growth in a breast cancer model.

ACTA PHARMACEUTICA SINICA B (2022)

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Article Engineering, Biomedical

Tumor microenvironment responsive nanogels as a smart triggered release platform for enhanced intracellular delivery of doxorubicin

Parveen Kumar et al.

Summary: The dual stimuli responsive nanogels synthesized in this study can achieve targeted drug delivery in tumor microenvironment, exhibiting favorable traits such as pH and redox dependent controlled drug release, biodegradability, biocompatibility, and enhanced cytotoxicity.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2021)

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Article Materials Science, Biomaterials

Dual pH-responsive-charge-reversal micelle platform for enhanced anticancer therapy

Jianhong Liao et al.

Summary: A novel nanodrug delivery system based on PDPP block copolymers was developed to enhance in vitro cellular uptake and anticancer efficacy. The charge-reversal of micelles from negative to positive at pH 6.5 significantly enhanced cellular uptake and anticancer efficacy.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Biochemistry & Molecular Biology

Enhancing the stability of zein/fucoidan composite nanoparticles with calcium ions for quercetin delivery

Hong Zhang et al.

Summary: In this study, composite nanoparticles based on zein and fucoidan were prepared, and the effects of different calcium ion concentrations on the stability of the system loaded with quercetin were investigated. It was found that the addition of Ca2+ improved the release of active substances from the nanoparticles, especially at a concentration of 1.5 mM. This suggests potential applications for these composite nanosystems in delivering active substances.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Biochemistry & Molecular Biology

Solution properties of N-(2-allyl-butyl ether)-O-carboxymethyl chitosan and N-(2-allyl-isooctyl ether)-O-carboxymethyl chitosan

Qun Liu et al.

Summary: pH-sensitive and amphiphilic chitosan derivatives were synthesized and studied for their rheological properties, showing that high degree of substitution and pH near the isoelectric points corresponded to low viscosity and viscoelasticity. Strong networks formed at high concentrations, and the role of Ca2+ varied depending on concentration levels. Molecular dynamics simulations were also used to examine intermolecular hydrogen bonds.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Biochemistry & Molecular Biology

Development and characterization of soybean protein isolate and fucoidan nanoparticles for curcumin encapsulation

Lihong Fan et al.

Summary: By embedding curcumin in core-shell nanoparticles using protein-polysaccharide complexes, the stability and dispersibility of Cur were effectively enhanced, providing a simple method for Cur delivery with potential applications for delivering lipid-soluble active ingredients.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Review Chemistry, Multidisciplinary

Smart Polymer Nanogels as Pharmaceutical Carriers: A Versatile Platform for Programmed Delivery and Diagnostics

Namitha K. Preman et al.

Summary: Smart polymeric nanoformulations have shown excellent capabilities in encapsulating and delivering therapeutic and diagnostic cargos with responsiveness to various stimuli. In the past decade, multifunctional NGs with excellent targetability and sensitivity have been reported for a wide range of theragnostic applications.

ACS OMEGA (2021)

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Article Dentistry, Oral Surgery & Medicine

The dual anti-caries effect of carboxymethyl chitosan nanogel loaded with chimeric lysin ClyR and amorphous calcium phosphate

Yun Zhu et al.

Summary: The study demonstrated that CMC-ClyR-ACP nanogel exhibited superior abilities in inhibiting biofilm formation and enamel demineralization compared to other treatment groups, showing stronger antibacterial properties and lower enamel hardness loss.

EUROPEAN JOURNAL OF ORAL SCIENCES (2021)

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Article Chemistry, Physical

Encapsulation of curcumin using fucoidan stabilized zein nanoparticles: Preparation, characterization, and in vitro release performance

Hong Zhang et al.

Summary: The composite nanosystem prepared with fucoidan and zein demonstrated good stability and high encapsulation efficiency for hydrophobic active substances encapsulation and delivery.

JOURNAL OF MOLECULAR LIQUIDS (2021)

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Review Biochemistry & Molecular Biology

Recent advances of emerging green chitosan-based biomaterials with potential biomedical applications: A review

Ajahar Khan et al.

Summary: Chitosan, as a natural biopolymer, shows ecological sustainability and flexibility, making it a promising candidate for a wide range of applications. Research has found that nanomaterials based on chitosan and its derivatives play a significant role in biomedical applications, improving stability, promoting drug release, and increasing bioavailability.

CARBOHYDRATE RESEARCH (2021)

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Article Biophysics

Delivery of curcumin using a zein-xanthan gum nanocomplex: Fabrication, characterization, and in vitro release properties

Dachao Zhang et al.

Summary: This study successfully used xanthan gum as a stabilizer to improve the stability of zein nanoparticles. The addition of xanthan gum led to the formation of spherical nanoparticles with small particle size and negative zeta potential, which remained stable under various pH, temperature, and salt conditions. Additionally, the composite nanoparticles showed improved encapsulation efficiency and sustained release, making them suitable for delivering bioactive compounds in food and pharmaceutical preparations.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

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Article Biochemistry & Molecular Biology

3D-printed antioxidant antibacterial carboxymethyl cellulose/ε-polylysine hydrogel promoted skin wound repair

Xiaoxue Wang et al.

Summary: A novel printable bionic hydrogel with antibacterial and antioxidant properties was developed to effectively treat large and irregular-shaped wounds by inhibiting inflammation and accelerating wound healing. The hydrogels showed excellent properties such as high compression modulus, stable rheological properties, effective antibacterial effects, and the ability to remove excessive reactive oxygen species. In comparison to commercial dressings, these hydrogels demonstrated better expression of VEGF and CD31, accelerated granulation tissue regeneration, and promoted wound healing.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Biochemistry & Molecular Biology

Comparative studies of chitosan and carboxymethyl chitosan doped with nickel and copper: Characterization and antibacterial potential

Edward O. Olanipekun et al.

Summary: The study focused on the preparation and antibacterial evaluation of chitosan, carboxymethyl chitosan, and their respective metal composites. The results showed that carboxymethyl chitosan and its metal composites performed better at inhibiting microbial growth than chitosan and its metal composites, as revealed by SEM, EDS, and XRD analysis.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Biochemistry & Molecular Biology

The immunostimulatory effects of hydroxypropyltrimethyl ammonium chloride chitosan-carboxymethyl chitosan nanoparticles

Chaojie Xu et al.

Summary: This study generated chitosan nanoparticles and examined their effects on dendritic cells, finding that 200kDa NO-CMC-HACC nanoparticles showed strong potential as immunological adjuvants.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Chemistry, Physical

Fabrication and characterization of zein-alginate oligosaccharide complex nanoparticles as delivery vehicles of curcumin

Fangyuan Jiang et al.

Summary: The study demonstrated that the complex nanoparticle system of zein stabilized with alginate oligosaccharides (AOS) was relatively stable under different conditions and showed a good sustained-release effect for delivering encapsulated lipophilic bioactive compounds.

JOURNAL OF MOLECULAR LIQUIDS (2021)

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Review Chemistry, Multidisciplinary

Soft materials as biological and artificial membranes

Shukun Tang et al.

Summary: This review discusses the emergence of soft materials in synthetic biology, with a focus on biological and artificial membranes. It highlights the construction of non-native membranes and polymeric membranes for medical applications, as well as the preparation of artificial membranes using synthetic materials. By modifying artificial membranes through traditional chemical methods, such as click reactions, targeted delivery of nanocarriers and controlled release of therapeutics can be achieved. Biological membranes with active domains play a crucial role in disease targeting and inspire the development of nanocarriers with artificial membranes for complex diseases.

CHEMICAL SOCIETY REVIEWS (2021)

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Review Materials Science, Biomaterials

pH-Sensitive nanogels for drug delivery in cancer therapy

Zhen Li et al.

Summary: Nanogels are considered ideal drug carriers for cancer treatment due to their high stability, water content, and drug loading capacities. pH-sensitive nanogels, which utilize the lower pH value in tumor tissue, have shown potential for more precise drug delivery and release in cancer treatment.

BIOMATERIALS SCIENCE (2021)

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Article Chemistry, Applied

Preparation and properties of a highly elastic galactomannan- poly (acrylamide- N, N-bis (acryloyl) cysteamine) hydrogel with reductive stimuli-responsive degradable properties

Yuxue Gao et al.

CARBOHYDRATE POLYMERS (2020)

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Review Biochemistry & Molecular Biology

Stimuli-responsive Drug Delivery Nanocarriers in the Treatment of Breast Cancer

Joao A. Oshiro-Junior et al.

CURRENT MEDICINAL CHEMISTRY (2020)

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Article Biochemistry & Molecular Biology

Stabilization of zein nanoparticles with k-carrageenan and tween 80 for encapsulation of curcumin

Xiaoxiao Sun et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Review Chemistry, Multidisciplinary

Mannosylated nanocarriers mediated site-specific drug delivery for the treatment of cancer and other infectious diseases: A state of the art review

Tulshidas S. Patil et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Materials Science, Biomaterials

A bio-responsive 6-mercaptopurine/doxorubicin based Click Chemistry polymeric prodrug for cancer therapy

Jianhong Liao et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

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Article Biochemistry & Molecular Biology

Injectable and Self-Healing Nanocomposite Hydrogels with Ultrasensitive pH-Responsiveness and Tunable Mechanical Properties: Implications for Controlled Drug Delivery

Meng Wu et al.

BIOMACROMOLECULES (2020)

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Article Biophysics

Polyphotosensitizer nanogels for GSH-responsive histone deacetylase inhibitors delivery and enhanced cancer photodynamic therapy

Nian Liu et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2020)

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Article Pharmacology & Pharmacy

Hypoxia-responsive folic acid conjugated glycol chitosan nanoparticle for enhanced tumor targeting treatment

Eun Hyang Jang et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

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Article Materials Science, Biomaterials

pH/GSH-Dual-Sensitive Hollow Mesoporous Silica Nanoparticle-Based Drug Delivery System for Targeted Cancer Therapy

Zhongyin Chen et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

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Review Pharmacology & Pharmacy

Nanogel: A Versatile Nano-Delivery System for Biomedical Applications

Yanlong Yin et al.

PHARMACEUTICS (2020)

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Article Biochemistry & Molecular Biology

Preparation and properties of carboxymethyl chitosan/oxidized hydroxyethyl cellulose hydrogel

Pengjie Lin et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Biochemistry & Molecular Biology

Cytotoxicity influence of new chitosan composite on HEPG-2, HCT-116 and MCF-7 carcinoma cells

Huda E. Abdelwahab et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Biophysics

Study on different particle sizes of DOX-loaded mixed micelles for cancer therapy

Chenglei Li et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2020)

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Article Biochemistry & Molecular Biology

Fabrication of soy protein isolate/cellulose nanocrystal composite nanoparticles for curcumin delivery

Songyan Wang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Chemistry, Applied

Designing, structural determination and biological effects of rifaximin loaded chitosan- carboxymethyl chitosan nanogel

Samah Attia Algharib et al.

CARBOHYDRATE POLYMERS (2020)

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Article Chemistry, Medicinal

Folic acid functionalized nanoparticles as pharmaceutical carriers in drug delivery systems

Asghar Narmani et al.

DRUG DEVELOPMENT RESEARCH (2019)

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Article Biochemistry & Molecular Biology

Carboxymethyl chitosan-based nanogels via acid-labile ortho ester linkages mediated enhanced drug delivery

Shuting Li et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Article Biochemistry & Molecular Biology

Fabrication of magnetic bentonite/carboxymethyl chitosan/sodium alginate hydrogel beads for Cu (II) adsorption

Hong Zhang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Article Biochemistry & Molecular Biology

Antitumor evaluation of carboxymethyl chitosan based norcantharidin conjugates against gastric cancer as novel polymer therapeutics

Jinhua Chi et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Article Pharmacology & Pharmacy

Folic Acid and PEI Modified Mesoporous Silica for Targeted Delivery of Curcumin

Xiaoxiao Sun et al.

PHARMACEUTICS (2019)

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Article Nanoscience & Nanotechnology

Co-Delivery of Docetaxel and Salinomycin to Target Both Breast Cancer Cells and Stem Cells by PLGA/TPGS Nanoparticles

Jie Gao et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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Article Nanoscience & Nanotechnology

A Nanodrug Consisting Of Doxorubicin And Exosome Derived From Mesenchymal Stem Cells For Osteosarcoma Treatment In Vitro

Hongxiang Wei et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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Article Chemistry, Multidisciplinary

Fabrication of Customized Nanogel Carriers From a UV-Triggered Dynamic Self-Assembly Strategy

Wuren Bao et al.

FRONTIERS IN CHEMISTRY (2019)

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Article Pharmacology & Pharmacy

Fabrication of Ion-Crosslinking Aminochitosan Nanoparticles for Encapsulation and Slow Release of Curcumin

Xiaoxiao Sun et al.

PHARMACEUTICS (2019)

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Article Chemistry, Applied

pH-sensitive and specific ligand-conjugated chitosan nanogels for efficient drug delivery

Lei Xing et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Article Chemistry, Multidisciplinary

Reprogramming the T cell response to cancer by simultaneous, nanoparticle-mediated PD-L1 inhibition and immunogenic cell death

Cao Dai Phung et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Article Chemistry, Multidisciplinary

Flexible Nanoparticles Reach Sterically Obscured Endothelial Targets Inaccessible to Rigid Nanoparticles

Jacob W. Myerson et al.

ADVANCED MATERIALS (2018)

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Article Chemistry, Applied

Genipin-crosslinked carboxymethyl chitosan nanogel for lung-targeted delivery of isoniazid and rifampin

Ting Wu et al.

CARBOHYDRATE POLYMERS (2018)

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Review Chemistry, Medicinal

Disulfide bond based polymeric drug carriers for cancer chemotherapy and relevant redox environments in mammals

Pei Zhang et al.

MEDICINAL RESEARCH REVIEWS (2018)

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Article Polymer Science

Redox/temperature responsive nonionic nanogel and photonic crystal hydrogel: Comparison between N, N′-Bis(acryloyl)cystamine and N, N′-methylenebisacrylamide

Xueting Li et al.

POLYMER (2018)

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Article Polymer Science

Synthesis of bioreducible core crosslinked star polymers with N,N '-bis(acryloyl)cystamine crosslinker via aqueous ethanol dispersion RAFT polymerization

Qijing Chen et al.

POLYMER (2018)

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Review Chemistry, Medicinal

Redox-responsive nano-carriers as tumor-targeted drug delivery systems

Ali Raza et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

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Review Biochemistry & Molecular Biology

Carboxymethyl chitosan: Properties and biomedical applications

Zahra Shariatinia

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

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Article Chemistry, Medicinal

Folate Receptor-Targeted and GSH-Responsive Carboxymethyl Chitosan Nanoparticles Containing Covalently Entrapped 6-Mercaptopurine for Enhanced Intracellular Drug Delivery in Leukemia

Xuan Wei et al.

MARINE DRUGS (2018)

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Article Biochemistry & Molecular Biology

Comparison in docetaxel-loaded nanoparticles based on three different carboxymethyl chitosans

Enhui Zhang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2017)

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Article Nanoscience & Nanotechnology

Synthesis and In Vitro Characterization of Carboxymethyl Chitosan-CBA-Doxorubicin Conjugate Nanoparticles as pH-Sensitive Drug Delivery Systems

Rui Hu et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2017)

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Review Materials Science, Biomaterials

An overview of carboxymethyl derivatives of chitosan: Their use as biomaterials and drug delivery systems

Bruno Fonseca-Santos et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2017)

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Article Chemistry, Applied

Facile preparation of pH/reduction dual-responsive prodrug microspheres with high drug content for tumor intracellular triggered release of DOX

Ruinian Zhang et al.

REACTIVE & FUNCTIONAL POLYMERS (2017)

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Article Multidisciplinary Sciences

Hollow MnO2 as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses

Guangbao Yang et al.

NATURE COMMUNICATIONS (2017)

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Review Materials Science, Biomaterials

Recent advances in engineered chitosan-based nanogels for biomedical applications

Hongxia Wang et al.

JOURNAL OF MATERIALS CHEMISTRY B (2017)

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Article Chemistry, Physical

Reduction-responsive zwitterionic nanogels based on carboxymethyl chitosan for enhancing cellular uptake in drug release

Liping Zhang et al.

COLLOID AND POLYMER SCIENCE (2016)

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Article Biochemical Research Methods

Targeted Smart pH and Thermoresponsive N,O-Carboxymethyl Chitosan Conjugated Nanogels for Enhanced Therapeutic Efficacy of Doxorubicin in MCF-7 Breast Cancer Cells

Neeraj K. Verma et al.

BIOCONJUGATE CHEMISTRY (2016)

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Article Nanoscience & Nanotechnology

A pH-Sensitive Nanosystem Based on Carboxymethyl Chitosan for Tumor-Targeted Delivery of Daunorubicin

Xueqiong Zhang et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2016)

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Review Biotechnology & Applied Microbiology

The effect of nanoparticle size on in vivo pharmacokinetics and cellular interaction

Nazanin Hoshyar et al.

NANOMEDICINE (2016)

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Review Radiology, Nuclear Medicine & Medical Imaging

Applications of nanoparticles for diagnosis and therapy of cancer

S. C. Baetke et al.

BRITISH JOURNAL OF RADIOLOGY (2015)

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Review Biochemistry & Molecular Biology

Chitosan-based nanoparticles for tumor-targeted drug delivery

M. Prabaharan

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2015)

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Article Medicine, Research & Experimental

Superparamagnetic Reduction/pH/Temperature Multistimuli-Responsive Nanoparticles for Targeted and Controlled Antitumor Drug Delivery

Jin Zeng et al.

MOLECULAR PHARMACEUTICS (2015)

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Review Biochemistry & Molecular Biology

Application of Chitosan-Based Nanocarriers in Tumor-Targeted Drug Delivery

Mohammad Ali Ghaz-Jahanian et al.

MOLECULAR BIOTECHNOLOGY (2015)

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Article Chemistry, Physical

A magnetic nanogel based on O-carboxymethylchitosan for antitumor drug delivery: synthesis, characterization and in vitro drug release

Carla Albetina Demarchi et al.

SOFT MATTER (2014)

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Article Polymer Science

Glycidyl methacrylate-modified gum arabic mediated graphene exfoliation and its use for enhancing mechanical performance of hydrogel

Jinchen Fan et al.

POLYMER (2013)

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Article Chemistry, Applied

Grafting of sodium carboxymethylcellulose (CMC) with glycidyl methacrylate and development of UV curable coatings from CMC-g-GMA induced by cationic photoinitiators

OH Lin et al.

CARBOHYDRATE POLYMERS (2005)

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Delivery of doxorubicin by dual responsive carboxymethyl chitosan based nanogel and in vitro performance

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