4.6 Article

Plasma complement component 4 alterations in patients with schizophrenia before and after antipsychotic treatment

期刊

ASIAN JOURNAL OF PSYCHIATRY
卷 73, 期 -, 页码 -

出版社

ELSEVIER
DOI: 10.1016/j.ajp.2022.103110

关键词

Complement component 4; Schizophrenia; Antipsychotic drug; C-reactive protein

资金

  1. Foundation of Medical Science and Technology of Guangdong Province [B2020150]
  2. Shantou University Medical College Innovation and Strengthening Foundation [923-38040248]

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This study found that the plasma level of C4 is increased in schizophrenia patients at the acute stage of illness and can be decreased by antipsychotic medication.
This study was performed to investigate the plasma C4 level and the influence of antipsychotic medication in schizophrenic patients. Thirty-six schizophrenic patients were followed-up for a mean of four weeks. The plasma level of C4 in schizophrenia was significantly higher than that in healthy controls at baseline, and was significantly decreased after antipsychotic treatment. CRP at both baseline and follow-up in patients were comparable to that in healthy controls. Our findings indicate that the plasma level of C4 is increased in schizophrenia patients at the acute stage of illness and can be decreased by antipsychotic medication.

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