BUB1 Is Identified as a Potential Therapeutic Target for Pancreatic Cancer Treatment

Article Immunology

BUB1 predicts poor prognosis and immune status in liver hepatocellular carcinoma

Wenbo Qi et al.

Summary: By investigating potential molecular markers, the immune microenvironment status of liver hepatocellular carcinoma (LIHC) was evaluated, and BUB1 was identified as a potential prognostic biomarker for LIHC.

APMIS (2022)

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Article Biochemistry & Molecular Biology

ScRNA-seq identified the metabolic reprogramming of human colonic immune cells in different locations and disease states

Qiuchen Zhao et al.

Summary: This study investigated the metabolic reprogramming of human colonic immune cells in different locations and disease states. The findings revealed distinct metabolic characteristics of immune cells in different regions and states, and identified the relationship between impaired immune cell function in ulcerative colitis and dysregulated cellular metabolism.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022)

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Article Biology

Statistics and network-based approaches to identify molecular mechanisms that drive the progression of breast cancer

Shahin Alam et al.

Summary: This study identified differentially expressed genes (DEGs) between breast cancer (BC) and control samples, constructed a protein-protein interaction network, and selected key genes. The DEGs were found to significantly enrich key biological processes, molecular functions, cellular components, and pathways related to BC, and had strong prognostic power. Transcriptional and post-transcriptional regulators of these key genes were also detected. Additionally, three repurposable candidate-drugs for BC treatment were suggested and validated through molecular docking analysis.

COMPUTERS IN BIOLOGY AND MEDICINE (2022)

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Article Health Care Sciences & Services

Single-Cell Sequencing Identifies the Heterogeneity of CD8+T Cells and Novel Biomarker Genes in Hepatocellular Carcinoma

Hailei Wang et al.

Summary: This study revealed the heterogeneity of different CD8+ T cell subsets in hepatocellular carcinoma (HCC) using single-cell RNA sequencing data. The cytotoxic CD8 T cell subset 4 was found to be closely associated with the survival and prognosis of HCC, and four differential genes were identified as potential biological markers for HCC.

JOURNAL OF HEALTHCARE ENGINEERING (2022)

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Article Behavioral Sciences

Integrated analysis of single-cell RNA-seq dataset and bulk RNA-seq dataset constructs a prognostic model for predicting survival in human glioblastoma

Wenwen Lai et al.

Summary: This study constructed a novel prognostic model by integrating different datasets to accurately predict the survival of GBM patients, providing valuable information for developing new therapeutic targets and improving clinical outcomes.

BRAIN AND BEHAVIOR (2022)

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Article Medicine, General & Internal

Risk-Related Genes and Associated Signaling Pathways of Gastrointestinal Stromal Tumors

Fulai Gao et al.

Summary: This study used bioinformatics tools to identify differentially expressed genes in gastrointestinal stromal tumors (GISTs) and analyze the related signaling pathways. The expression of CENPA, CDK1, TPX2, CCNB1, CCNA2, BUB1, AURKA, KIF11, and NDC80 genes was found to be associated with the risk of GIST formation. These genes encode proteins that regulate the division, proliferation, and apoptosis of GISTs mainly through the PI3K/AKT, MARK, P53, WNT, and other signaling pathways.

INTERNATIONAL JOURNAL OF GENERAL MEDICINE (2022)

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Article Oncology

BUB1 drives the occurrence and development of bladder cancer by mediating the STAT3 signaling pathway

Ning Jiang et al.

Summary: The study revealed that increased expression of BUB1 in human bladder cancer was associated with the activation of STAT3 signaling. Inhibition of BUB1 kinase activity effectively suppressed BCa cell proliferation and cancer progression both in vitro and in vivo. The BUB1/STAT3 complex played a critical role in promoting the transcription of STAT3 target genes, highlighting the potential of BUB1 as a therapeutic target for bladder cancer treatment.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Biochemistry & Molecular Biology

Single-cell transcriptomics reveals heterogeneous progression and EGFR activation in pancreatic adenosquamous carcinoma

Xin Zhao et al.

Summary: The study used single-cell RNA sequencing to reveal the heterogeneity of pancreatic adenosquamous carcinoma (PASC), identifying cell clusters, potential biomarkers, and intercellular interactions, while defining associated signaling pathways.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Article Biochemical Research Methods

CellPhoneDB: inferring cell-cell communication from combined expression of multi-subunit ligand-receptor complexes

Mirjana Efremova et al.

NATURE PROTOCOLS (2020)

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Article Biochemical Research Methods

ReactomeGSA-Efficient Multi-Omics Comparative Pathway Analysis

Johannes Griss et al.

MOLECULAR & CELLULAR PROTEOMICS (2020)

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Review Immunology

Dendritic cells in cancer immunology and immunotherapy

Stefanie K. Wculek et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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Article Cell Biology

Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma

Junya Peng et al.

CELL RESEARCH (2019)

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Article Genetics & Heredity

High expression of CDK1 and BUB1 predicts poor prognosis of pancreatic ductal adenocarcinoma

Junjie Piao et al.

GENE (2019)

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Article Oncology

Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts

Ela Elyada et al.

CANCER DISCOVERY (2019)

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Article Oncology

Single-Cell Transcriptomics of Pancreatic Cancer Precursors Demonstrates Epithelial and Microenvironmental Heterogeneity as an Early Event in Neoplastic Progression

Vincent Bernard et al.

CLINICAL CANCER RESEARCH (2019)

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Article Biotechnology & Applied Microbiology

Dimensionality reduction for visualizing single-cell data using UMAP

Etienne Becht et al.

NATURE BIOTECHNOLOGY (2019)

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Review Pathology

Dendritic cells in pancreatic cancer immunotherapy: Vaccines and combination immunotherapies

Jia Yang et al.

PATHOLOGY RESEARCH AND PRACTICE (2019)

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Review Oncology

Advances in pancreatic cancer biomarkers

Syed Hasan et al.

ONCOLOGY REVIEWS (2019)

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Article Immunology

Blockade of MIF-CD74 Signalling on Macrophages and Dendritic Cells Restores the Antitumour Immune Response Against Metastatic Melanoma

Carlos R. Figueiredo et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Cell Biology

The biological function and significance of CD74 in immune diseases

Huiting Su et al.

INFLAMMATION RESEARCH (2017)

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Article Biochemical Research Methods

Reversed graph embedding resolves complex single-cell trajectories

Xiaojie Qiu et al.

NATURE METHODS (2017)

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Article Multidisciplinary Sciences

Genetic and pharmacological inhibition of TTK impairs pancreatic cancer cell line growth by inducing lethal chromosomal instability

Jeran K. Stratford et al.

PLOS ONE (2017)

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Article Oncology

A Novel MIF Signaling Pathway Drives the Malignant Character of Pancreatic Cancer by Targeting NR3C2

Shouhui Yang et al.

CANCER RESEARCH (2016)

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Article Oncology

Prognostic Value of SMAD4 in Pancreatic Cancer: A Meta-Analysis

Xing Shugang et al.

TRANSLATIONAL ONCOLOGY (2016)

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Article Medicine, General & Internal

Pancreatic cancer

Jorg Kleeff et al.

NATURE REVIEWS DISEASE PRIMERS (2016)

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Review Oncology

Central adiposity, obesity during early adulthood, and pancreatic cancer mortality in a pooled analysis of cohort studies

J. M. Genkinger et al.

ANNALS OF ONCOLOGY (2015)

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Article Public, Environmental & Occupational Health

Physical activity and risk of pancreatic cancer: a systematic review and meta-analysis

Gundula Behrens et al.

EUROPEAN JOURNAL OF EPIDEMIOLOGY (2015)

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Article Dermatology

Cell Surface CD74-MIF Interactions Drive Melanoma Survival in Response to Interferon-γ

Keiji Tanese et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2015)

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Article Biochemistry & Molecular Biology

limma powers differential expression analyses for RNA-sequencing and microarray studies

Matthew E. Ritchie et al.

NUCLEIC ACIDS RESEARCH (2015)

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Article Multidisciplinary Sciences

Biological and Clinical Significance of MAD2L1 and BUB1, Genes Frequently Appearing in Expression Signatures for Breast Cancer Prognosis

Zhanwei Wang et al.

PLOS ONE (2015)

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Article Multidisciplinary Sciences

Prognostic Fifteen-Gene Signature for Early Stage Pancreatic Ductal Adenocarcinoma

Dung-Tsa Chen et al.

PLOS ONE (2015)

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Article Gastroenterology & Hepatology

2564 resected periampullary adenocarcinomas at a single institution: trends over three decades

Jin He et al.

HPB (2014)

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Article Oncology

Carbohydrate antigen 19-9 is a prognostic and predictive biomarker in patients with advanced pancreatic cancer who receive gemcitabine-containing chemotherapy

Todd M. Bauer et al.

CANCER (2013)

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Article Oncology

Integration of Metabolomics and Transcriptomics Revealed a Fatty Acid Network Exerting Growth Inhibitory Effects in Human Pancreatic Cancer

Geng Zhang et al.

CLINICAL CANCER RESEARCH (2013)

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Correction Oncology

Cigarette smoking and pancreatic cancer: an analysis from the International Pancreatic Cancer Case-Control Consortium (Panc4) (vol 23, pg 1880, 2012)

C. Bosetti

ANNALS OF ONCOLOGY (2012)

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Article Oncology

Red and processed meat consumption and risk of pancreatic cancer: meta-analysis of prospective studies

S. C. Larsson et al.

BRITISH JOURNAL OF CANCER (2012)

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Article Biotechnology & Applied Microbiology

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

Guangchuang Yu et al.

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2012)

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Article Gastroenterology & Hepatology

CD74 and macrophage migration inhibitory factor as therapeutic targets in gastric cancer

Ying-Xia Zheng et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2012)

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Article Cell Biology

Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation

Robin M. Ricke et al.

JOURNAL OF CELL BIOLOGY (2011)

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Article Genetics & Heredity

SEURAT: Visual analytics for the integrated analysis of microarray data

Alexander Gribov et al.

BMC MEDICAL GENOMICS (2010)

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Article Oncology

Whole Chromosome Instability Caused by Bub1 Insufficiency Drives Tumorigenesis through Tumor Suppressor Gene Loss of Heterozygosity

Darren J. Baker et al.

CANCER CELL (2009)

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Article Respiratory System

Macrophage CD74 contributes to MIF-induced pulmonary inflammation

Koichiro Takahashi et al.

RESPIRATORY RESEARCH (2009)

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Article Immunology

Inhibition of macrophage migration inhibitory factor or its receptor (CD74) attenuates growth and invasion of DU-145 prostate cancer cells

Katherine L. Meyer-Siegler et al.

JOURNAL OF IMMUNOLOGY (2006)

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Article Oncology

Borderline resectable pancreatic cancer: Definitions, management, and role of preoperative therapy

Gauri R. Varadhachary et al.

ANNALS OF SURGICAL ONCOLOGY (2006)

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Article Immunology

MIF signal transduction initiated by binding to CD74

L Leng et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2003)

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Article Oncology

Overexpression of the mitotic checkpoint genes BUB1, BUBR1, and BUB3 in gastric cancer -: association with tumour cell proliferation

H Grabsch et al.

JOURNAL OF PATHOLOGY (2003)

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Article Oncology

Elevated tumour marker CA19-9: clinical interpretation and influence of obstructive jaundice

DV Mann et al.

EUROPEAN JOURNAL OF SURGICAL ONCOLOGY (2000)

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BUB1 Is Identified as a Potential Therapeutic Target for Pancreatic Cancer Treatment

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