期刊
JOURNAL OF ETHNOPHARMACOLOGY
卷 180, 期 -, 页码 78-86出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jep.2016.01.013
关键词
Aging; Cognition; Centella asiatica; Mitochondrial dysfunction; Reactive oxygen species
资金
- NIH-NCCAM Grant [R01AT008099]
- Oregon Alzheimer's Disease Center (OADC) [3P30-AG008017 24 S1]
- NIH-NCCAM [AT002688]
- Department of Veterans Affairs
Ethnopharmacological relevance: This study investigates the cognitive enhancing effects of the plant Centella asiatica which is widely used Ayurvedic and traditional Chinese medicine. Aim of the study: The goal of this study was to determine the effects of a water extract of the medicinal plant Centella asiatica (CAW) on cognitive ability as well as mitochondrial and antioxidant response pathways in vivo. Materials and methods: Old and young C57BL/6 mice were treated with CAW (2 mg/mL) in their drinking water. Learning and memory was assessed using Morris Water Maze (MWM) and then tissue was collected and gene expression analyzed. Results: CAW improved performance in the MWM in aged animals and had a modest effect on the performance of young animals. CAW also increased the expression of mitochondria] and antioxidant response genes in the brain and liver of both young and old animals. Expression of synaptic markers was also increased in the hippocampus and frontal cortex, but not in the cerebellum of CAW-treated animals. Conclusions: These data indicate a cognitive enhancing effect of CAW in healthy mice. The gene expression changes caused by CAW suggest a possible effect on mitochondrial biogenesis, which in conjunction with activation of antioxidant response genes could contribute to cognitive improvement. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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