Association Between Sleep Traits and Rheumatoid Arthritis: A Mendelian Randomization Study

Article Rheumatology

Sleep problems in rheumatoid arthritis over 12 years from diagnosis: results from the Swedish EIRA study

Lauren Lyne et al.

Summary: In this cohort of newly diagnosed patients with RA, sleep problems were mainly related to pain and reduced function. Treatment of sleep problems in RA should focus on treating the underlying issue causing sleep disturbances.

RMD OPEN (2022)

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Article Cardiac & Cardiovascular Systems

Therapeutic Targets for Heart Failure Identified Using Proteomics and Mendelian Randomization

Albert Henry et al.

Summary: This study investigated the associations and causal relationships of 90 cardiovascular proteins with heart failure (HF). It identified 44 proteins that were associated with incident HF, of which 8 showed evidence of a causal relationship and 7 were druggable. Adrenomedullin (ADM) was highlighted as a particularly promising drug target.

CIRCULATION (2022)

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Article Geriatrics & Gerontology

Genetically Predicted Levels of Circulating Inflammatory Cytokines and the Risk and Age at Onset of Parkinson's Disease: A Two-Sample Mendelian Randomization Study

Yating Zhao et al.

Summary: This study used Mendelian randomization to explore the association between inflammatory cytokines and Parkinson's disease (PD). The results show a causal association between circulating levels of macrophage inflammatory protein-1 beta (MIP1b) and PD risk, and a suggestive association between interleukin-16 (IL-16) levels and PD risk. These findings suggest that MIP1b and IL-16 may be novel biomarkers and potential therapeutic targets for PD development.

FRONTIERS IN AGING NEUROSCIENCE (2022)

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Article Neurosciences

Mendelian Randomization Analysis Suggests No Associations of Herpes Simplex Virus Infections With Multiple Sclerosis

Wan Zhang et al.

Summary: This study used Mendelian randomization (MR) to investigate the relationship between infection with herpes simplex virus (HSV) and the risk of multiple sclerosis (MS). The results showed that genetically predicted HSV infection was not associated with the risk of MS. Additional sensitivity analyses confirmed the robustness of these null findings. Therefore, this study did not support a causal relationship between genetic susceptibly to HSV and MS.

FRONTIERS IN NEUROSCIENCE (2022)

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Review Biochemistry & Molecular Biology

Update on the role of extracellular vesicles in rheumatoid arthritis

Hai-Bing Miao et al.

Summary: This review discusses the role of extracellular vesicles (EVs) in the pathogenesis of rheumatoid arthritis (RA) and presents evidence supporting the therapeutic potential of EVs from different sources.

EXPERT REVIEWS IN MOLECULAR MEDICINE (2022)

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Review Rheumatology

Persistent inflammatory and non-inflammatory mechanisms in refractory rheumatoid arthritis

Maya H. Buch et al.

Summary: This review focuses on two types of refractory rheumatoid arthritis (RA) patients: those with persistent inflammatory refractory RA (PIRRA) and those with non-inflammatory refractory RA (NIRRA). Identifying individuals with predominant PIRRA or NIRRA is crucial for informing distinct treatment and management approaches for refractory RA.

NATURE REVIEWS RHEUMATOLOGY (2021)

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Meeting Abstract Rheumatology

IMPACT OF SLEEP DISTURBANCES ON ELDERLY PATIENTS WITH RHEUMATOID ARTHRITIS

M. Sellami et al.

ANNALS OF THE RHEUMATIC DISEASES (2021)

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Meeting Abstract Rheumatology

MENTAL HEALTH, SLEEP AND COGNITION CHARACTERISTICS IN RHEUMATOID ARTHRITIS AND ASSOCIATIONS WITH RHEUMATOID FACTOR STATUS IN THE UK BIOBANK

I. Stanciu et al.

ANNALS OF THE RHEUMATIC DISEASES (2021)

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Article Immunology

Causal Effects of Gut Microbiome on Systemic Lupus Erythematosus: A Two-Sample Mendelian Randomization Study

Kun Xiang et al.

Summary: This study used Mendelian randomization to examine the causal links between gut microbiome components and SLE risk. The results suggest that certain gut microbiome components may have causal effects on the risk of SLE, with some components increasing the risk and others reducing it.

FRONTIERS IN IMMUNOLOGY (2021)

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Meeting Abstract Medicine, General & Internal

ARA Abstracts

Kade Paterson et al.

INTERNAL MEDICINE JOURNAL (2021)

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Article Medicine, Research & Experimental

Association between IL-33 and other inflammatory factors in patients with rheumatoid arthritis and in fibroblast-like synoviocytes in vitro

Jing Wu et al.

Summary: IL-33 has been found to exhibit an association with multiple cytokines and chemokines in synovial fluid, with a U-type dose-dependent regulatory effect on FLS function demonstrated in vitro. The applicability of the U-shaped curve fit in clinical practice is limited.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

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Article Medicine, Research & Experimental

Cognitive behavioural therapy for insomnia in patients with rheumatoid arthritis: protocol for the randomised, single-blinded, parallel-group Sleep-RA trial

K. M. Latocha et al.

TRIALS (2020)

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Article Genetics & Heredity

Serum Uric Acid Level and Multiple Sclerosis: A Mendelian Randomization Study

Peng-Peng Niu et al.

FRONTIERS IN GENETICS (2020)

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Article Urology & Nephrology

Short or Long Sleep Duration and CKD: A Mendelian Randomization Study

Sehoon Park et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2020)

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Article Public, Environmental & Occupational Health

Dose-response Relationship between Sleep and Rheumatoid Arthritis

Wenwen Wu et al.

AMERICAN JOURNAL OF HEALTH BEHAVIOR (2020)

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Meeting Abstract Rheumatology

I NEVER THOUGHT EXERCISE COULD HELP IMPROVE MY SLEEP: EXPERIENCES OF PEOPLE WITH RHEUMATOID ARTHRITIS ON THE IMPACT OF EXERCISE ON SLEEP

S. Mckenna et al.

ANNALS OF THE RHEUMATIC DISEASES (2020)

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Meeting Abstract Rheumatology

ESTIMATED SLEEP DURATION AND CARDIOVASCULAR RISK IN RHEUMATOID ARTHRITIS: A CASE CONTROL STUDY

D. A. Galarza-Delgado et al.

ANNALS OF THE RHEUMATIC DISEASES (2020)

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Article Genetics & Heredity

Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways

Philip R. Jansen et al.

NATURE GENETICS (2019)

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Article Genetics & Heredity

Biological and clinical insights from genetics of insomnia symptoms

Jacqueline M. Lane et al.

NATURE GENETICS (2019)

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Article Clinical Neurology

Risky behaviors and Parkinson disease A mendelian randomization study

Sandeep Grover et al.

NEUROLOGY (2019)

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Article Rheumatology

Frequency of sleep disorders in patients with rheumatoid arthritis

Mohammad Mustafa et al.

OPEN ACCESS RHEUMATOLOGY-RESEARCH AND REVIEWS (2019)

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Article Rheumatology

Poster Presentation Abstracts

International Journal of Rheumatic Diseases (2018)

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Article Medicine, General & Internal

Sleep Quality in Patients with Rheumatoid Arthritis and Associations with Pain, Disability, Disease Duration, and Activity

Igor Grabovac et al.

JOURNAL OF CLINICAL MEDICINE (2018)

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Article Rheumatology

Sleep disturbance in patients with rheumatoid arthritis is related to fatigue, disease activity, and other patient-reported outcomes

C. Austad et al.

SCANDINAVIAN JOURNAL OF RHEUMATOLOGY (2017)

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Article Public, Environmental & Occupational Health

Interpreting findings from Mendelian randomization using the MR-Egger method

Stephen Burgess et al.

EUROPEAN JOURNAL OF EPIDEMIOLOGY (2017)

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Article Public, Environmental & Occupational Health

MendelianRandomization: an R package for performing Mendelian randomization analyses using summarized data

Olena O. Yavorska et al.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2017)

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Article Endocrinology & Metabolism

Inflammation Is an Important Covariate for the Crosstalk of Sleep and the HPA Axis in Rheumatoid Arthritis

Rainer H. Straub et al.

NEUROIMMUNOMODULATION (2017)

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Article Genetics & Heredity

Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator

Jack Bowden et al.

GENETIC EPIDEMIOLOGY (2016)

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Article Medicine, General & Internal

Sleep quality and factors affecting sleep in elderly patients with rheumatoid arthritis in Turkey

Seda Pehlivan et al.

TURKISH JOURNAL OF MEDICAL SCIENCES (2016)

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Article Medicine, General & Internal

Association of sleep duration with rheumatoid arthritis in Korean adults: analysis of seven years of aggregated data from the Korea National Health and Nutrition Examination Survey (KNHANES)

Jae-Hyun Kim et al.

BMJ OPEN (2016)

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Article Public, Environmental & Occupational Health

Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

Jack Bowden et al.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2015)

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Article Clinical Neurology

Sleep Disorders and Increased Risk of Autoimmune Diseases in Individuals without Sleep Apnea

Yi-Han Hsiao et al.

SLEEP (2015)

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Article Clinical Neurology

Sleep Disorders and Increased Risk of Autoimmune Diseases in Individuals without Sleep Apnea

Yi-Han Hsiao et al.

SLEEP (2015)

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Article Clinical Neurology

Insomnia as a risk factor for ill health: results from the large population-based prospective HUNT Study in Norway

Borge Sivertsen et al.

JOURNAL OF SLEEP RESEARCH (2014)

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Article Multidisciplinary Sciences

Genetics of rheumatoid arthritis contributes to biology and drug discovery

Yukinori Okada et al.

NATURE (2014)

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Article Genetics & Heredity

Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data

Stephen Burgess et al.

GENETIC EPIDEMIOLOGY (2013)

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Article Immunology

Role of interleukin-6 in stress, sleep, and fatigue

Nicolas Rohleder et al.

NEUROIMMUNOMODULATION IN HEALTH AND DISEASE I (2012)

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Review Physiology

Sleep and immune function

Luciana Besedovsky et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2012)

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Article Immunology

Sleep-dependent activity of T cells and regulatory T cells

T. Bollinger et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2009)

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Review Mathematical & Computational Biology

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

Debbie A. Lawlor et al.

STATISTICS IN MEDICINE (2008)

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Article Physiology

Effects of sleep deprivation on the development of autoimmune disease in an experimental model of systemic lupus erythematosus

Beatriz Duarte Palma et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2006)

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Letter Rheumatology

A longitudinal study of clinical symptoms and sleep parameters in rheumatoid arthritis

AM Drewes et al.

RHEUMATOLOGY (2000)

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Association Between Sleep Traits and Rheumatoid Arthritis: A Mendelian Randomization Study

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