期刊
LIFE SCIENCES IN SPACE RESEARCH
卷 36, 期 -, 页码 59-69出版社
ELSEVIER
DOI: 10.1016/j.lssr.2022.08.001
关键词
MiR-138-5p; SIRT1; Microgravity; Proliferation; Apoptosis
In this study, it was found that miR-138-5p was upregulated under simulated microgravity, inhibiting osteoblast proliferation and promoting osteoblast apoptosis. Additionally, SIRT1 was downregulated and negatively correlated with miR-138-5p expression, suggesting that miR-138-5p inhibits osteoblast proliferation and promotes osteoblast apoptosis by targeting SIRT1. Therefore, the miR-138-5p/SIRT1 pathway should be considered for preventative treatment of disuse osteoporosis.
Microgravity can inhibit osteoblast proliferation and promote apoptosis, which is related to a reduction in mechanical stress on the bones and results in disuse osteoporosis, but the detailed mechanism is still unclear. In this study, we first demonstrated that miR-138-5p was upregulated, inhibited osteoblast proliferation and induced osteoblast apoptosis under simulated microgravity. Moreover, miR-138-5p silencing partially mitigated the effects of proliferation and apoptosis of MC3T3-E1 cells. Our study further showed that sirtuin 1 (SIRT1) was downregulated and negatively correlated with the expression of miR-138-5p under simulated microgravity, which indicated that miR-138-5p inhibited osteoblast proliferation and promoted osteoblast apoptosis by targeting SIRT1. Thus, the miR-138-5p/SIRT1 pathway should be considered for preventative treatment of disuse osteoporosis.
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