4.7 Article

Chronic administration tetrahydroxystilbene glucoside promotes hippocampal memory and synaptic plasticity and activates ERKs, CaMKII and SIRT1/miR-134 in vivo

期刊

JOURNAL OF ETHNOPHARMACOLOGY
卷 190, 期 -, 页码 74-82

出版社

ELSEVIER IRELAND LTD
DOI: 10.1016/j.jep.2016.06.012

关键词

2,3,5,4 '-tetrahydroxystilbene-2-o-beta-D-glucoside; Memory; Synaptic plasticity; ERK; CaMKII; SIRT1/miR-134

资金

  1. NSFC (NSFC) [81573414, 81222048]
  2. National Basic Research Program of China (973 Program) [2013CB531303]
  3. Independent Innovation Foundation of Huazhong University of Science and Technology [2014QT017]

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Ethnopharmacological Relevance: Polygonum multiflorum Thunb is a traditional Chinese medicine with anti-aging effect. 2,3,5,4'-tetrahydroxystilbene-2-0-beta-D-glucoside (TSG) is generally considered as the main active component in Polygonum multiflorum Thunb. However, the effect of TSG on memory in adult is unclear till now. Aim of study: 2,3,5,4'-tetrahydroxystilbene-2-0-beta-D-glucoside (TSG) is a polyphenols compound from Polygonum multiflorum Thunb. The present study aimed to evaluate the effect of chronic administration of TSG on hippocampal memory in normal mice. Materials and methods: Behavioral test, electrophysiology and golgi staining were used to evaluate the effect of TSG on hippocampus-dependent memory and synaptic plasticity. Western blotting was used to determine the expression of ERK1/2, CaMKII, and SIRT1. Real-time quantitative PCR was explored to measure miR-134. Results: It was found that TSG enhanced hippocampus-dependent contextual fear memory and novel object recognition, facilitated hippocampal LTP and increased dendrite spine density in the CA1 region of hippocampus. TSG obviously promoted the phosphorylations of ERK1/2, CaMKII, CREB and the expression of BDNF in the hippocampus, with upregulation of silent information regulator 1 (SIRT1) and downregulation of miR-134. Conclusions: Chronic administration of TSG promotes hippocampal memory in normal mice, suggesting that supplementary of TSG might serve as an enhancement of memory. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

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