期刊
DIAGNOSTICS
卷 12, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/diagnostics12061408
关键词
circulating lymphocytes; colorectal carcinoma; tumor immune response; flow cytometry; tumor-infiltrating lymphocytes; lymph node size
This study found that circulating lymphocytes, especially cytotoxic T cells, are associated with the local antitumor immune response in colorectal cancer patients. The results also demonstrate that the size of lymph nodes and the metastasis-to-lymph node size ratio have an impact on the immune response in these patients.
Tumor-infiltrating lymphocytes (TILs) correlate with the number and size of the surrounding lymph nodes in patients with colorectal carcinoma (CRC) and reflect the quality of the antitumor immune response. In this prospective study, we analyzed whether this response correlated with the circulating lymphocytes in peripheral blood (PB). In 47 patients with newly diagnosed CRC, flow cytometry was performed to analyze the B cells, T cells, NK cells, and a variety of their subsets in PB. The results were correlated with TILs in the resected tumor and with the number and size of the surrounding lymph nodes in nodal negative (N- patients (LN5: number of lymph nodes measuring >= 5 mm) and the metastasis-to-lymph node size ratio (MSR) in nodal positive patients (N+). Differences between the number of TILs could be seen between N+ and N- patients, dependent on the LN5 and MSR categories, with higher values in N- cases and in patients with a higher LN5 category or a lower MSR. Additionally, higher values of various circulating lymphocyte subgroups were observed in these patients. For the total PB lymphocytes, CD8 cells, and some of their subgroups, a positive correlation with the TILs was found. This study shows that circulating lymphocytes-in particular, cytotoxic T cells-correlate with the local antitumor immune response displayed by TILs and lymph node activation. Our findings indicate that local and generalized antitumor immune responses are concordant with their different components.
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