4.7 Article

Chemical Constituents of the Flowers of Pueraria lobata and Their Cytotoxic Properties

期刊

PLANTS-BASEL
卷 11, 期 13, 页码 -

出版社

MDPI
DOI: 10.3390/plants11131651

关键词

Pueraria lobata; Puerariae Flos; tryptophan derivatives; flavonoids; cytotoxicity; ovarian cancer

资金

  1. National Research Foundation of Korea (NRF) - Ministry of Science and ICT (MSIT), Republic of Korea [NRF2019R1A2C1083945]

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The extract of Puerariae Flos showed significant activity against human ovarian cancer cells in a preliminary study. This research aimed to identify the active compounds in Pueraria Flos and found several compounds that demonstrated cytotoxicity against the cancer cells.
The flower of Pueraria lobata (Puerariae Flos) is a reddish-purple to violet-purple flower that blooms between July and September. In our preliminary study, Puerariae Flos extract exhibited significant activity against a human ovarian cancer cell line. This research aims to identify the active compounds in Pueraria Flos. By repeated chromatography, one new tryptophan derivative (1), two new flavanones (4 and 5), and 19 known compounds, including tryptophan derivatives (2 and 3), flavonoids (6-9), isoflavonoids (10-20), a flavonolignan (21), and a phenolic compound (22), were isolated from a methanol extract of Puerariae Flos. The structures of new compounds were elucidated as 13-N-benzoyl-L-tryptophan-1-N-beta-D-glucopyranoside (1), 2-hydroxy-5-methoxy-naringenin (4), and 2-hydroxy-5-methoxy-naringenin-7-O-beta-D-glucopyranoside (5). Among the isolates, afromosin (17), tectorigenin (11), apigenin (8), glycitein (16), (-)-hydnocarpin (21), irilin D (12), irisolidone 7-O-glucoside (14), and genistein (10) showed cytotoxicity against human ovarian cancer cell line A2780. Apigenin (8) and (-)-hydnocarpin (21) were the most active (IC50 values of 9.99 and 7.36 mu M, respectively).

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