4.5 Article

Voxel-Mirrored Homotopic Connectivity Is Altered in Meibomian Gland Dysfunction Patients That Are Morbidly Obese

期刊

BRAIN SCIENCES
卷 12, 期 8, 页码 -

出版社

MDPI
DOI: 10.3390/brainsci12081078

关键词

morbid obesity; voxel-mirrored homotopic connectivity; meibomian gland dysfunction; functional connectivity; fMRI

资金

  1. National Natural Science Foundation [82160195]
  2. Central Government Guides Local Science and Technology Development Foundation [20211ZDG02003]
  3. Key Research Foundation of Jiangxi Province [20181BBG70004, 20203BBG73059]

向作者/读者索取更多资源

Patients with morbid obesity and meibomian gland dysfunction exhibit altered functional connectivity in specific brain areas, which may be related to their clinical presentations.
Purpose: To investigate the altered functional connectivity (FC) of the cerebral hemispheres in patients with morbid obesity (MO) with meibomian gland dysfunction (MGD) by voxel-mirrored homotopic connectivity (VMHC). Methods: Patients and matched healthy controls (HCs) were recruited, and all subjects underwent functional resonance magnetic imaging (fMRI), and VMHC results were processed statistically to assess the differences in FC in different brain regions between the two groups. We further used ROC curves to evaluate the diagnostic value of these differences. We also used Pearson's correlation analysis to explore the relationship between changes in VMHC values in specific brain regions, visual acuity, and Mini-Mental State Examination (MMSE) score. Conclusions: Patients with morbid obesity and MGD had abnormal FC in the cerebral hemispheres in several specific brain areas, which were mainly concentrated in pathways related to vision and perception and may correlate to some extent with the clinical presentations of the patients.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据