Latest developments in the pathobiology of Ewing sarcoma

Ewing's sarcoma (ES) is an aggressive malignant tumor commonly affecting adolescents. The standard of care includes surgical treatment and systemic therapies, although ES patients often develop drug resistance, leading to disease progression. Tumorigenesis in Ewing's sarcoma has unique characteristics that allow for the development of targeted therapeutics. New data on the role of oncogenic drivers in ES tumorigenesis, particularly in relation to treatment-induced stress, offers new therapeutic opportunities. This review summarizes the latest information on the clinically relevant oncogenes found in Ewing's sarcoma, their biological roles, and candidate targets for improving ES patient outcomes.

Automated summary

Ewing's sarcoma is a common aggressive tumor that mainly affects adolescents. Current standard treatment includes surgery and systemic therapy, but patients often develop drug resistance. Recent research has identified unique characteristics in the tumorigenesis of Ewing's sarcoma, offering potential for targeted therapy.