期刊
ANTIBIOTICS-BASEL
卷 11, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/antibiotics11070955
关键词
Acinetobacter baumannii; COVID-19; WGS
资金
- University of L'Aquila [07_PROGETTO_RICER CA_ATENEO]
This study analyzed the antimicrobial susceptibility of 43 strains of A. baumannii isolated from patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and bacterial sepsis. The strains were found to be resistant to multiple classes of antibiotics, including carbapenems and colistin. Whole-genome sequencing revealed the presence of various insertion sequences, which enhance the ability of A. baumannii to acquire and transfer antibiotic resistance genes. The bacteria also showed the presence of virulence factors and belonged to the sequence type 2 international clone.
A total of 43 A. baumannii strains, isolated from 43 patients affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and by bacterial sepsis, were analyzed by antimicrobial susceptibility testing. All strains were resistant to almost three different classes of antibiotics, including carbapenems and colistin. The whole-genome sequencing (WGS) of eight selected A. baumannii isolates showed the presence of different insertion sequences (ISs), such as ISAba13, ISAba26, IS26, ISVsa3, ISEc29, IS6100 and IS17, giving to A. baumannii a high ability to capture and mobilize antibiotic resistance genes. Resistance to carbapenems is mainly mediated by the presence of OXA-23, OXA-66 and OXA-82 oxacillinases belonging to OXA-51-like enzymes. The presence of AmpC cephalosporinase, ADC-25, was identified in all A. baumannii. The pathogenicity of A. baumannii was exacerbated by the presence of several virulence factors. The multi-locus sequence typing (MLST) analysis showed that all strains belong to sequence type 2 (ST) international clone.
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