期刊
ANTIBIOTICS-BASEL
卷 11, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/antibiotics11081060
关键词
antivirulence therapy; antimicrobial resistance; small-molecule inhibitors; Pseudomonas aeruginosa infection; elastase LasB
资金
- Bundesministerium fur Bildung und Forschung (BMBF) [05CARB-X0891]
- [16GW0346]
LasB, a zinc metalloprotease and a crucial virulence factor of Pseudomonas aeruginosa, has become a key target in the development of novel antivirulence agents. This review provides an overview of the structure of its active site and a summary of the disclosed P. aeruginosa LasB inhibitors, with a specific focus on their binding modes and strategies for targeting LasB by small molecules.
Elastase B (LasB) is a zinc metalloprotease and a crucial virulence factor of Pseudomonas aeruginosa. As the need for new strategies to fight antimicrobial resistance (AMR) constantly rises, this protein has become a key target in the development of novel antivirulence agents. The extensive knowledge of the structure of its active site, containing two subpockets and a zinc atom, led to various structure-based medicinal chemistry programs and the optimization of several chemical classes of inhibitors. This review provides a brief reminder of the structure of the active site and a summary of the disclosed P. aeruginosa LasB inhibitors. We specifically focused on the analysis of their binding modes with a detailed representation of them, hence giving an overview of the strategies aiming at targeting LasB by small molecules.
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