4.6 Review

Photodynamic Therapy for Peri-Implant Diseases

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Article Oncology

Effect of multiple sessions of photodynamic therapy on bone regeneration around dental implants among patients with peri-implantitis

Shatha Subhi ALHarthi et al.

Summary: The study assessed the effect of antimicrobial photodynamic therapy (aPDT) on bone regeneration around dental implants. The results showed that aPDT as an adjunct to mechanical debridement (MD) can reduce the severity of peri-implant mucositis but does not contribute significantly to bone regeneration.

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY (2022)

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From Bench to Bedside in Precision Medicine: Diabetes Mellitus and Peri-Implantitis Clinical Indices with a Short-Term Follow-Up: A Systematic Review and Meta-Analysis

Mario Dioguardi et al.

Summary: This systematic review investigated the relationship between peri-implant inflammation indices and glycemic levels in patients with diabetes mellitus. The results showed worse outcomes in patients with diabetes, even in the short term, for peri-implant inflammation indices. However, due to the lack of consistency in the definition of peri-implantitis and its clinical indicators among studies, the literature linking glycaemic control to peri-implant disease is highly heterogeneous.

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Review Biochemistry & Molecular Biology

Efficacy of Adjunctive Antimicrobial Photodynamic Therapy to Mechanical Debridement in the Treatment of Peri-implantitis or Peri-implant Mucositis in Smokers: A Systematic Review and Meta-analysis

Rojin Shahmohammadi et al.

Summary: This study aimed to assess the effectiveness of adjunctive antimicrobial photodynamic therapy in treating peri-implant diseases in smokers. The results showed a significant difference in pocket depth and plaque index at the 3-month follow-up between the MD+a-PDT group and the MD alone group, but due to methodological heterogeneity and limited number of studies, conclusive evidence for the efficacy of a-PDT in improving clinical parameters in smokers is lacking.

PHOTOCHEMISTRY AND PHOTOBIOLOGY (2022)

Article Oncology

Peri-implant parameters and cytokine profile among Peri-implant disease patients treated with Er Cr YSGG laser and PDT

Montaser N. Alqutub

Summary: Er,Cr:YSGG (ECL) laser-assisted non-surgical treatment and Photodynamic therapy (PDT) as adjuncts to mechanical debridement (MD) are more effective in reducing pen-implant soft tissue inflammatory parameters for short-term use than MD alone.

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY (2022)

Review Dentistry, Oral Surgery & Medicine

Overview of Systematic Reviews and Meta-analyses Investigating the Efficacy of Different Nonsurgical Therapies for the Treatment of Peri-implant Diseases

Amruta A. Joshi et al.

Summary: This study summarizes the methodologic quality and outcome measures from systematic reviews and meta-analyses evaluating the efficacy of different nonsurgical therapies for peri-implant diseases. The evidence suggests that nonsurgical therapies are effective for treating peri-implant mucositis, but there is inconclusive evidence for their efficacy in treating peri-implantitis. Future well-designed high-quality trials are encouraged to reassess the findings.

INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS (2022)

Review Dentistry, Oral Surgery & Medicine

Titanium Surface Decontamination: A Systematic Review of In Vitro Comparative Studies

Samy Francis et al.

Summary: This systematic review evaluated in vitro investigations on different treatment modalities to decontaminate titanium surfaces and identified the most effective cleaning procedures. Mechanical decontamination showed better results compared to laser and chemical procedures. Among mechanical modalities, air abrasion demonstrated the best cleaning effectiveness. Chlorhexidine showed comparable results with all tested substances in chemical methods. Diode laser was found to be more promising compared to other tested lasers.

INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS (2022)

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Bone loss around implants-is it metallosis?

Thomas G. Wilson

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Review Dentistry, Oral Surgery & Medicine

Peri-implantitis is not periodontitis: Scientific discoveries shed light on microbiome-biomaterial interactions that may determine disease phenotype

Georgios A. Kotsakis et al.

Summary: Peri-implantitis is an immune-mediated complication attributed to bacterial biofilms on the implant surface. Revisiting its pathogenesis is necessary due to the lack of efficacy of antimicrobial treatments and recent discoveries from microbial studies.

PERIODONTOLOGY 2000 (2021)

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The efficacy of systemic antibiotics as an adjunct to surgical treatment of peri-implantitis: a systematic review

Malene Oen et al.

Summary: The adjunctive use of systemically administered antibiotics in surgical treatment of peri-implantitis does not provide significant benefits, and there is a lack of uniform diagnosis criteria, high-quality long-term randomized controlled trials, and information on conflict of interest.

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Synergistic Photoantimicrobial Chemotherapy of Methylene Blue-Encapsulated Chitosan on Biofilm-Contaminated Titanium

Chiu-Nan Lin et al.

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PHARMACEUTICALS (2021)

Article Oncology

Clinical, bacterial, and inflammatory outcomes of indocyanine green-mediated photodynamic therapy for treating periimplantitis among diabetic patients: A randomized controlled clinical trial

Nawaf Labban et al.

Summary: This study aimed to evaluate the efficacy of indocyanine green mediated photodynamic therapy (ICG-PDT) as an adjunct to peri-implant manual debridement (PIMD) in the treatment of peri-implantitis among Diabetes Mellitus patients. The results showed that the ICG-PDT group had superior treatment outcomes in certain parameters compared to the PIMD group, particularly in the reduction of Porphyromonas gingivalis and Treponema denticola.

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY (2021)

Review Oncology

Antimicrobial photodynamic therapy versus antibiotics as an adjunct in the treatment of periodontitis and peri-implantitis: A systematic review and meta-analysis

Yuxin Zhao et al.

Summary: The clinical efficacy of adjunctive antimicrobial photodynamic therapy and antibiotics in the treatment of periodontitis and peri-implantitis showed equal evidence, with significant reduction of the red complex in both diseases. However, due to protocol heterogeneity in studies and limited number of trials, the comparative conclusion remains inconclusive. Future long-term clinical trials with standardized protocols are needed to provide a firm conclusion.

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY (2021)

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Natural Photosensitizers in Antimicrobial Photodynamic Therapy

Ece Polat et al.

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BIOMEDICINES (2021)

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Survival Rates of Dental Implants in Autogenous and Allogeneic Bone Blocks: A Systematic Review

Phil Donkiewicz et al.

Summary: The study findings demonstrate the feasibility of achieving similar implant survival rates with AUBB and ALBB in pre-implant bone grafting, but factors related to more extensive augmentation procedures can affect implant survival rates. Further long-term comparative studies are needed.

MEDICINA-LITHUANIA (2021)

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Light Sources and Dosimetry Techniques for Photodynamic Therapy

Michele M. Kim et al.

PHOTOCHEMISTRY AND PHOTOBIOLOGY (2020)

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The Microbiome of Peri-Implantitis: A Systematic Review and Meta-Analysis

Philipp Sahrmann et al.

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Blue photosensitizers for aPDT eliminate Aggregatibacter actinomycetemcomitans in the absence of light: An in vitro study

Luisa Andrade Valle et al.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2019)

Article Dentistry, Oral Surgery & Medicine

Adjunctive photodynamic therapy improves the outcomes of peri-implantitis: a randomized controlled trial

H. Wang et al.

AUSTRALIAN DENTAL JOURNAL (2019)

Article Dentistry, Oral Surgery & Medicine

Surgical Therapy of Peri-Implantitis with Local Minocycline: A 6-Month Randomized Controlled Clinical Trial

J. K. Cha et al.

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Antimicrobial Efficacy of Photodynamic Therapy and Light-Activated Disinfection Against Bacterial Species on Titanium Dental Implants

Bleron Azizi et al.

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Frank Schwarz et al.

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Peri-implant health, peri-implant mucositis, and peri-implantitis: Case definitions and diagnostic considerations

Stefan Renvert et al.

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Effect of photodynamic and laser therapy in the treatment of peri-implant mucositis: A systematic review

Abdulaziz M. Albaker et al.

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Photodynamic therapy for the treatment of peri-implant diseases: A network meta-analysis of randomized controlled trials

Gowri Sivaramakrishnan et al.

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY (2018)

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Dental implants - are they better than natural teeth?

Bjarni E. Pjetursson et al.

EUROPEAN JOURNAL OF ORAL SCIENCES (2018)

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Microstructural Evaluation of Contaminated Implant Surface Treated by Lase r, Photodynamic Therapy, and Chlorhexidine 2%

Anna Saffarpour et al.

INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS (2018)

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Emphysema following air-powder abrasive treatment for peri-implantitis

Sung-Tak Lee et al.

MAXILLOFACIAL PLASTIC AND RECONSTRUCTIVE SURGERY (2018)

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Association between diabetes mellitus/hyperglycaemia and peri-implant diseases: Systematic review and meta-analysis

Alberto Monje et al.

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Increased Levels of Dissolved Titanium Are Associated With Peri-Implantitis - A Cross-Sectional Study

Luciana M. Safioti et al.

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Excited State Dynamics of a Photobiologically Active Ru(II) Dyad Are Altered in Biologically Relevant Environments

Christian Reichardt et al.

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Antimicrobial effect of blue light using Porphyromonas gingivalis pigment

Ayaka Yoshida et al.

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Effectiveness of implant surface debridement using particle beams at differing air pressures

Max C. T. Wei et al.

CLINICAL AND EXPERIMENTAL DENTAL RESEARCH (2017)

Article Radiology, Nuclear Medicine & Medical Imaging

Evaluation of Effectiveness of Photodynamic Therapy With Low-level Diode Laser in Nonsurgical Treatment of Peri-implantitis

Ehsan Birang et al.

JOURNAL OF LASERS IN MEDICAL SCIENCES (2017)

Article Dentistry, Oral Surgery & Medicine

A retrospective study on 1592 consecutively performed operations in one private referral clinic. Part II: Peri-implantitis and implant failures

Torsten Jemt et al.

CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH (2017)

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Microbiota at teeth and implants in partially edentulous patients. A 10-year retrospective study

Sigrun Eick et al.

CLINICAL ORAL IMPLANTS RESEARCH (2016)

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Metal elements in tissue with dental peri-implantitis: a pilot study

Tobias Fretwurst et al.

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Effectiveness of Implant Therapy Analyzed in a Swedish Population: Prevalence of Peri-implantitis

J. Derks et al.

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New photosensitizers for photodynamic therapy

Heidi Abrahamse et al.

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Bactericidal Effect of Erbium-Doped Yttrium Aluminum Garnet Laser and Photodynamic Therapy on Aggregatibacter Actinomycetemcomitans Biofilm on Implant Surface

Anna Saffarpour et al.

INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS (2016)

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Factors Influencing Early Dental Implant Failures

B. R. Chrcanovic et al.

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Antimicrobial Photodynamic Therapy of S. mutans Biofilms Attached to Relevant Dental Materials

Michelle L. Zoccolillo et al.

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Efficiency of photodynamic therapy in the treatment of peri-implantitis - A three-month randomized controlled clinical trial

Dragana Rakasevic et al.

SRPSKI ARHIV ZA CELOKUPNO LEKARSTVO (2016)

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Dental implants and diabetes mellitus-a systematic review

Hendrik Naujokat et al.

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Efficacy of Antimicrobial Photodynamic Therapy as an Adjunctive to Mechanical Debridement in the Treatment of Peri-implant Diseases: A Randomized Controlled Clinical Trial

Mohammad Reza Karimi et al.

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The Antimicrobial Photodynamic Therapy in the Treatment of Peri-Implantitis

Umberto Romeo et al.

INTERNATIONAL JOURNAL OF DENTISTRY (2016)

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In Vitro Investigation of the Effect of Oral Bacteria in the Surface Oxidation of Dental Implants

Sathyanarayanan Sridhar et al.

CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH (2015)

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Risk indicators for peri-implantitis. A narrative review

Stefan Renvert et al.

CLINICAL ORAL IMPLANTS RESEARCH (2015)

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Evaluation of survival and success rates of dental implants reported in longitudinal studies with a follow-up period of at least 10 years: a systematic review

V. Moraschini et al.

INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY (2015)

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Innovative Regeneration Technology to Solve Peri-implantitis by Er:YAG Laser Based on the Microbiologic Diagnosis: A Case Series

Toshiaki Yoshino et al.

INTERNATIONAL JOURNAL OF PERIODONTICS & RESTORATIVE DENTISTRY (2015)

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Primary prevention of peri-implantitis: Managing peri-implant mucositis

Soren Jepsen et al.

JOURNAL OF CLINICAL PERIODONTOLOGY (2015)

Article Dentistry, Oral Surgery & Medicine

The Influence of Smoking on the Peri-Implant Microbiome

A. A. Tsigarida et al.

JOURNAL OF DENTAL RESEARCH (2015)

Article Dentistry, Oral Surgery & Medicine

Chlorhexidine Uptake and Release From Modified Titanium Surfaces and Its Antimicrobial Activity

Hyo-Sook Ryu et al.

JOURNAL OF PERIODONTOLOGY (2015)

Article Dentistry, Oral Surgery & Medicine

Prevalence and Predictive Factors for Peri-Implant Disease and Implant Failure: A Cross-Sectional Analysis

Diane M. Daubert et al.

JOURNAL OF PERIODONTOLOGY (2015)

Article Dentistry, Oral Surgery & Medicine

The effect of photodynamic therapy on Aggregatibacter actinomycetemcomitans attached to surface-modified titanium

Kyungwon Cho et al.

JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE (2015)

Article Dentistry, Oral Surgery & Medicine

Prevalence of peri-implant inflammatory disease in patients with a history of periodontal disease who receive supportive periodontal therapy

Luis Antonio Aguirre-Zorzano et al.

CLINICAL ORAL IMPLANTS RESEARCH (2015)

Review Dentistry, Oral Surgery & Medicine

Smoking and the risk of peri-implantitis. A systematic review and meta-analysis

Fabrizio Sgolastra et al.

CLINICAL ORAL IMPLANTS RESEARCH (2015)

Review Dentistry, Oral Surgery & Medicine

Lasers in periodontal therapy

Euloir Passanezi et al.

PERIODONTOLOGY 2000 (2015)

Review Dentistry, Oral Surgery & Medicine

Systemic antibiotics in the treatment of periodontitis

Magda Feres et al.

PERIODONTOLOGY 2000 (2015)

Article Dentistry, Oral Surgery & Medicine

Microbiological diversity of peri-implantitis biofilm by Sanger sequencing

Ennyo S. C. da Silva et al.

CLINICAL ORAL IMPLANTS RESEARCH (2014)

Article Dentistry, Oral Surgery & Medicine

The effects of mechanical instruments on contaminated titanium dental implant surfaces: a systematic review

Anna Louropoulou et al.

CLINICAL ORAL IMPLANTS RESEARCH (2014)

Review Dentistry, Oral Surgery & Medicine

A systematic review and Bayesian network meta-analysis of randomized clinical trials on non-surgical treatments for peri-implantitis

Clovis M. Faggion et al.

JOURNAL OF CLINICAL PERIODONTOLOGY (2014)

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Microbiologically Induced Corrosive Properties of the Titanium Surface

A. Fukushima et al.

JOURNAL OF DENTAL RESEARCH (2014)

Review Dentistry, Oral Surgery & Medicine

Periodontally compromised vs. periodontally healthy patients and dental implants: A systematic review and meta- analysis

Bruno Ramos Chrcanovic et al.

JOURNAL OF DENTISTRY (2014)

Review Dentistry, Oral Surgery & Medicine

Systematic Review and Meta-Analysis of the Effect of Various Laser Wavelengths in the Treatment of Peri-Implantitis

Georgios A. Kotsakis et al.

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Article Biochemistry & Molecular Biology

Antimicrobial photodynamic therapy associated to nonsurgical periodontal treatment in smokers: Microbiological results

Adriana C. Queiroz et al.

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The effects of elevated hemoglobin A(1c) in patients with type 2 diabetes mellitus on dental implants Survival and stability at one year

Thomas W. Oates et al.

JOURNAL OF THE AMERICAN DENTAL ASSOCIATION (2014)

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Marina Salah Kamel et al.

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Fawad Javed et al.

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Tatsuro Koyanagi et al.

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Juliana Marotti et al.

LASERS IN MEDICAL SCIENCE (2013)

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Decontamination of dental implant surface in peri-implantitis treatment: A literature review

Ana Mellado-Valero et al.

MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL (2013)

Article Dentistry, Oral Surgery & Medicine

Anti-infective surgical therapy of peri-implantitis. A 12-month prospective clinical study

L. J. A. Heitz-Mayfield et al.

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Pyrosequencing reveals unique microbial signatures associated with healthy and failing dental implants

Purnima S. Kumar et al.

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Glycemic Control and Implant Stabilization in Type 2 Diabetes Mellitus

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Application of antimicrobial photodynamic therapy in periodontal and peri-implant diseases

Aristeo A. Takasaki et al.

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Mark Wainwright

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Phenothiazinium derivatives for pathogen inactivation in blood products

Mark Wainwright et al.

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Lethal photosensitisation of oral bacteria and its potential application in the photodynamic therapy of oral infections

M Wilson

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MN Usacheva et al.

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Assessment of photodynamic destruction of Escherichia coli O157 : H7 and Listeria monocytogenes by using ATP bioluminescence

NA Romanova et al.

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YN Konan et al.

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