期刊
FRONTIERS IN MEDICINE
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmed.2022.871714
关键词
COVID-19; rale score; biomarkers; inflammation; SARS-CoV-2
资金
- Spanish Ministry of Science and Innovation [SAF2017-89714-R, PID2020-120336RB-I00, PID2019-110906RB-I00]
- Carlos III Health Institute
- European Regional Development Fund (FEDER) [PI18/00209, CB16/10/00435]
- CSIC General Foundation [109_RESIFIT]
- EU Funded H2020DIABFRAIL-LATAM [825546]
- European Joint Programming Initiative A Healthy Diet for a Healthy Life (JPI HDHL), ERA-NET Cofund ERA-HDHL [CHOKOAGE AC20/00026]
- Generalitat Valenciana [PROMETEO/2019/032, PROMETEO/2019/097]
- H2020 Societal Challenges Programme [825546] Funding Source: H2020 Societal Challenges Programme
This study analyzed the inflammatory state of COVID-19 patients and identified admission biomarkers for predicting disease worsening.
BackgroundCoronavirus disease 2019 (COVID-19) has placed enormous pressure on intensive care units (ICUs) and on healthcare systems in general. A deeper understanding of the pathophysiology of the most severe forms of COVID-19 would help guide the development of more effective interventions. Herein, we characterized the inflammatory state of patients with COVID-19 of varying degrees of severity to identify admission biomarkers for predicting COVID-19 worsening. DesignAdmission blood samples were obtained from 78 patients with COVID-19. Radiographic assessment of lung edema (RALE) scoring was calculated by imaging. Platelet and leukocyte counts were measured by flow cytometry, and plasma levels of C-reactive protein were assessed by immunoturbidimetry, and interleukin (IL)-8/CXCL8, IL-10, tumor necrosis factor (TNF)-alpha, interferon (IFN)-gamma, and monocyte chemoattractant protein-1 (MCP-1/CCL2) levels by enzyme-linked immunosorbent assay (ELISA). ResultsThe RALE score correlated with several admission hemogram (platelets, neutrophils, and lymphocytes) and inflammatory (IL-8/CXCL8, MCP-1/CCL2, IL-10, and C-reactive protein) parameters. COVID-19 worsening, based on the need for oxygen (Delta oxygen supply) during hospitalization, correlated negatively with admission lymphocyte counts but positively with neutrophil-to-lymphocyte ratio and with plasma levels of the inflammatory parameters correlating with RALE score. ConclusionOur data indicate a correlation between the RALE score and Delta oxygen supply and admission inflammatory status. The identification of a panel of biomarkers that reflect COVID severity might be useful to predict disease worsening during hospitalization and to guide clinical management of COVID-19-related complications. Finally, therapies targeting IL-8/CXCL8- or IL-10 activity may offer therapeutic approaches in COVID-19 treatment.
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